Results 61 to 70 of about 12,345 (165)
Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae [PDF]
, 2015 Non-homologous end joining (NHEJ) directly joins two broken DNA ends without sequence homology. A distinct pathway called microhomology-mediated end joining (MMEJ) relies on a few base pairs of homology between the recombined DNA.
Schiestl, Robert H +4 more
core +1 more source
, 2022 Predictive TMEJ code for analyzing genomic loci. Code employed in Stroik et al (under review) - Stepwise requirements for Polymerases δ and θ in Theta-mediated end joining.
aluthman
core +1 more source
, 2005 Class switch recombination (CSR) is a region-specific, transcriptionally regulated, nonhomologous recombinational process that is initiated by activation-induced cytidine deaminase (AID).
Lennart Hammarström +16 more
core +1 more source
CtIP promotes microhomology-mediated alternative end joining during class-switch recombination [PDF]
Nature Structural & Molecular Biology, 2010 Immunoglobulin heavy chain (Igh locus) class-switch recombination (CSR) requires targeted introduction of DNA double strand breaks (DSBs) into repetitive 'switch'-region DNA elements in the Igh locus and subsequent ligation between distal DSBs. Both canonical nonhomologous end joining (C-NHEJ) that seals DNA ends with little or no homology and a poorly
Lee-Theilen, Mieun +4 more
openaire +2 more sources
Frontiers in Genetics, 2021 Background: Emery–Dreifuss muscular dystrophy (EDMD) is a rare disease characterized by early joint contractures, slowly progressive muscular dystrophy, and cardiac involvement, which includes arrhythmia, dilated cardiomyopathy, hypertrophic ...
Danyu Song +5 more
doaj +1 more source
Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions [PDF]
Nucleic Acids Research, 2010 Ku or DNA ligase 4-independent alternative end joining (alt-EJ) repair of DNA double-strand breaks (DSBs) frequently correlates with increased junctional microhomology. However, alt-EJ also produces junctions without microhomology (apparent blunt joins), and the exact role of microhomology in both alt-EJ and classical non-homologous end joining (NHEJ ...
Yu, Amy Marie, McVey, Mitch
openaire +2 more sources
Stitching up broken DNA ends by FANCA
Molecular & Cellular Oncology, 2018 RAD52 rejoins resected broken DNA ends by mediating single-strand annealing. Our recent work elucidates that FANCA, a Fanconi anemia protein, also directly repairs double-strand breaks (DSBs) by catalyzing annealing of single-stranded DNA.
Anna Palovcak +3 more
doaj +1 more source
eLife, 2016 DNA polymerase θ (Polθ) promotes insertion mutations during alternative end-joining (alt-EJ) by an unknown mechanism. Here, we discover that mammalian Polθ transfers nucleotides to the 3’ terminus of DNA during alt-EJ in vitro and in vivo by oscillating ...
Tatiana Kent +3 more
doaj +1 more source
Rapid Screening for CRISPR-Directed Editing of the Drosophila Genome Using white Coconversion
G3: Genes, Genomes, Genetics, 2016 Adoption of a streamlined version of the bacterial clustered regular interspersed short palindromic repeat (CRISPR)/Cas9 defense system has accelerated targeted genome engineering. The Streptococcus pyogenes Cas9 protein, directed by a simplified, CRISPR-
Daniel Tianfang Ge +3 more
doaj +1 more source
Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex. [PDF]
Nucleic Acids Res, 2017 Microhomology-mediated end joining (MMEJ), an error-prone pathway for DNA double-strand break (DSB) repair, is implicated in genomic rearrangement and oncogenic transformation; however, its contribution to repair of radiation-induced DSBs has not been ...
Dutta A +11 more
europepmc +2 more sources