Results 141 to 150 of about 18,274 (287)
Medicinal Research Reviews, EarlyView.ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik +3 more
wiley +1 more source
New Plant Protection, EarlyView.Despite 17 years of development, the effectiveness of nanocarrier‐delivered RNAi pesticide (NDRP) for agricultural biological control remains limited. The successful development of effective NDRP development requires the coordinated optimization of target gene selection and nanocarrier properties, including RNA dosage, multi‐gene targeting, protection ...
Shi Dong Wang +4 more
wiley +1 more source
Antinociceptive effect of morphine microinjections into the spinal trigeminal subnucleus oralis.
, 1995 International audienceWe analysed the effects of morphine microinjections (0.2 microliter) into the subnucleus oralis (SNO), i.e. the rostral division of the spinal trigeminal nucleus, on the formalin test adapted for orofacial pain.
Luccarini, P +3 more
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Pest Management Science, EarlyView.Transcriptome sequencing of Ceutorhynchus obstrictus revealed RNA interference (RNAi) targets; double‐stranded RNA microinjection reduced transcript levels and increased mortality, with αCOP and Rop showing strongest lethal effects, indicating promising RNAi‐based pest control candidates.
Apurva Vikas Sabnis +8 more
wiley +1 more source
LsFAMeT and LsJHAMT coordinate JH biosynthesis to regulate fecundity in Laodelphax striatellus
Insect Science, EarlyView.The small brown planthopper (SBPH), Laodelphax striatellus, can trigger large‐scale outbreaks when encountering suitable habitats during migration due to their strong reproductive ability. This study investigated the role of juvenile hormone (JH) in regulating SBPH reproduction.
Yan Guo +3 more
wiley +1 more source
Insect Science, EarlyView.Overview of the mindset and long‐term goals with the approach suggested in this study. We provide a first proof of concept that male‐killing endosymbionts can be used to establish female biased populations with higher production efficiency than populations with a 50/50 sex ratio. This biological tool can have marked positive impact on future commercial
Stine F. Laursen +4 more
wiley +1 more source
Insect Science, EarlyView.• First demonstration of functional RNAi in the beet leafhopper, Neoaliturus tenellus, using both dsRNA microinjection and star polycation nanoparticle‐mediated topical spray delivery.•Microinjection achieved over 90% knockdown of Gus and Pum3, revealing gene‐specific fitness effects on survival and fecundity in beet leafhopper.•Nanoparticle‐mediated ...
Jinlong Han +8 more
wiley +1 more source
Insect Science, EarlyView.This diagram illustrates that the horizontally transferred panBC influences the level and localization of vitellogenin (Vg) by facilitating pantothenate production and juvenile hormone (JH) biosynthesis. In turn, Vg shields symbionts by suppressing autophagic degradation in bacteriocytes.
Xiang Sun +5 more
wiley +1 more source
5-HT <sub>2A</sub> receptor in medial prefrontal cortex mediates pain-related empathic responses in rats. [PDF]
Zool ResLuo WJ +6 more
europepmc +1 more source
Aphid and endosymbiont sensitivity to heatwaves is misaligned across life stages
Insect Science, EarlyView.Aphids depend on the obligate symbiont Buchnera aphidicola, which may constrain thermal tolerance. Using a factorial heatwave experiment, we exposed nymphs and adults to moderate or extreme temperatures and measured fitness and symbiont responses.
Evatt Chirgwin +6 more
wiley +1 more source