Results 201 to 210 of about 17,415 (301)
Generation and Characterization of Twist1 Acetyl‐Mimic and Acetyl‐Deficient Mouse Models
genesis, Volume 64, Issue 3, June 2026.ABSTRACT TWIST1 encodes a highly conserved basic helix–loop–helix transcription factor essential for embryonic development from Drosophila to humans. TWIST1 activity is regulated by post‐translational modifications, including phosphorylation during development and cancer metastasis. Recent cancer studies identified acetylation of lysines K73 and K76 as
Mary Elmeniawi +6 more
wiley +1 more source
Multiplexed Retinoic Acid Signal Reporters for In Vivo and In Vitro Use
genesis, Volume 64, Issue 3, June 2026.ABSTRACT Here we describe the optimisation of a modular, generally applicable and rapid method to make multimerised signaling‐molecule reporters for detecting different retinoic acid concentrations. The technical plasmid design allows for the easy exchange of reporters, promoters, signal‐responsive elements as well as for the multimerization of entire ...
Craig Smith +4 more
wiley +1 more source
ELECTROPHORESIS, Volume 47, Issue 6, Page 450-478, June 2026.This review provides a comprehensive summary of monoamine neurotransmitter analysis by capillary electrophoresis with amperometric detection. Fundamental principles of amperometric detection, electrode positioning strategies, and approaches to high‐voltage decoupling are described, followed by a critical comparison of electrode materials, selection of ...
Petr Kubáň +3 more
wiley +1 more source
MicrobiologyOpen, Volume 15, Issue 3, June 2026.Phage therapy shows promising efficacy against MDR, XDR, and PDR Pseudomonas aeruginosa infections across different models and administration routes. Evidence highlights reduced mortality, bacterial clearance, and synergy with antibiotics, while emphasizing the need for standardized protocols and advanced delivery systems to support clinical ...
Gustavo Aparecido da Cunha +7 more
wiley +1 more source
Molecular Genetics &Genomic Medicine, Volume 14, Issue 6, June 2026.Our study expands the variant spectrum of PLCZ1, enriches the clinical characteristics of PLCZ1, and provides a solid base for the genetic counseling, diagnosis, and treatment of this condition. ABSTRACT Background Variations in the PLCZ1 gene can lead to male infertility (MIM #617214), an autosomal recessive disorder characterized by failure or ...
Jinwei Yang +12 more
wiley +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Kaempferol has been shown to be beneficial in the treatment of Alzheimer's disease (AD) in animal models. However, the action mechanism remains unclear. AKR1B1 has been identified as a target of kaempferol, initially suggested by the Therapeutic Target Database, DrugBank, and PubChem, and subsequently confirmed through experimental validation.
Le Li +5 more
wiley +1 more source
Pest Management Science, Volume 82, Issue 6, Page 5184-5194, June 2026.Gene‐specific double‐stranded RNAs effectively silence essential genes in the invasive citrus pest Delottococcus aberiae, leading to significant mortality through both microinjection and oral delivery. These results provide proof of concept for RNA interference‐based biopesticides as selective and sustainable tools for citrus integrated pest management.
Carolina Gallego‐Giraldo +6 more
wiley +1 more source
Therapeutic Efficacy and Safety of Botulinum Toxin Type A in Erythematotelangiectatic Rosacea: A Systematic Review. [PDF]
CureusMarrar K +7 more
europepmc +1 more source
AMPKα Silencing Prevents Kanamycin‐Induced Ototoxicity in an Acute Mouse Model
Sensory Neuroscience, Volume 2, Issue 2, June 2026.Kanamycin plus furosemide (KM + FU) treatment (acute ototoxic model) causes AMPKα activation and rapidly induces cochlear outer hair cell (OHC) loss. Silencing AMPKα1 via posterior semicircular canal injection 48 h before KM + FU treatment reduces this damage, preserving OHCs and hearing.
Shengyu Zou +6 more
wiley +1 more source
Environmental Microbiology, Volume 28, Issue 6, June 2026.Native Regiella insecticola in Myzus persicae provides strong protection against parasitoid wasps but imposes only modest reproductive costs and does not affect virus transmission. Despite stable vertical and horizontal transmission, these effects alone do not explain the low natural prevalence of **Regiella** in field populations.
Qiong Yang +10 more
wiley +1 more source