Results 181 to 190 of about 18,274 (287)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, Volume 13, Issue 61, 3 November 2026.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Involvement of D1- and D2-like dopamine receptors in the hippocampal CA1 region in mediating the restraint stress-induced analgesia in the rats. [PDF]

IBRO Neurosci Rep
Shirmohammadi D, Golmohammadi H, Abtin S, Haghparast A.   +3 more
europepmc   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, Volume 13, Issue 61, 3 November 2026.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

The anterior cingulate cortex mediates cisplatin-induced mechanical allodynia and represents a target for cannabigerol antinociception. [PDF]

Mol Pain
Ferreira MV, Morris N, Wade Q, da Cunha JM, Graziane N.   +4 more
europepmc   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, Volume 13, Issue 61, 3 November 2026.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Optogenetic Hedonic Hotspots in the Orbitofrontal Cortex and Insula: Causing Enhancement of Sweetness "Liking". [PDF]

J Neurosci
Morales I, Berridge KC.
europepmc   +1 more source

Real‐Time Neurochemical Sensing in Zebrafish: Electrochemical and Fluorescent Approaches

Analysis &Sensing, Volume 6, Issue 6, November 2026.
The use of zebrafish has emerged as a powerful approach for real‐time neurochemical measurements. This review highlights recent advances in electrochemical and fluorescent sensing strategies that enable dynamic measurements in live preparations of this complex vertebrate. These complementary approaches provide new insights into neurochemical signaling,
Piyanka Hettiarachchi, Jacob T. Theismann, Michael A. Johnson   +2 more
wiley   +1 more source

Oxytocin receptor neurons in the adBNST modulate maternal-like behavior in mice. [PDF]

Zool Res
Gao PT, Zhang Y, Bai YT, Zhang LZ, Xie KR, Lin YR, Li W, Wei ZY, Tai FD, He ZX.   +9 more
europepmc   +1 more source

Targeting Ninjurin‐1‐Mediated Microglial Pyroptosis Attenuates Neuroinflammation and Neuronal Injury Following Intracerebral Hemorrhage

Brain and Behavior, Volume 16, Issue 11, November 2026.
In response to intracerebral hemorrhage, NF‐κB signaling upregulates Nlrp3 and Ninjurin‐1 (Ninj1) in microglia. NLRP3 inflammasome activation triggers GSDMD pore formation, whereas Ninj1 oligomerizes to execute terminal plasma membrane rupture (PMR) and DAMP release (such as HMGB1).
Liqiang Peng, Aosheng Peng, Hui Zhu, Ting Sun, Pan Liu, Ting Qi   +5 more
wiley   +1 more source

Role of Piezo1 Channels Expressed in PVN in Regulating Sympathetic Nerve Activity and Arterial Blood Pressure in Rats. [PDF]

Int J Mol Sci
Chen Y, Guo W, Wang J, Wang M, Yang Y, Miodonski GJ, Jiang E, Chen QH, Yang Y, Wang R.   +9 more
europepmc   +1 more source