Results 191 to 200 of about 17,415 (301)

Spinal Cord CELF4 in Chronic Constriction Injury-Induced Neuropathic Pain: Association with TRPV1 and COX-2 Expression. [PDF]

J Mol Neurosci
Kong G, Tan R, Zeng X, Zhang H, Zhang B, Yu J, Xie R.   +6 more
europepmc   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Hyperdiluted Triamcinolone Injections for Nasal and Alar Contouring. [PDF]

J Cosmet Dermatol
Yi KH, Lee S, Song JK, Kim JH, Jalali A, Pupo D.   +5 more
europepmc   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Brain CB2 receptor: a new target in medication development for treating opioid use disorder in rodents. [PDF]

Mol Psychiatry
Soler-Cedeño O, Zhang HY, Xiong E, Bi GH, Alton H, Maras M, Liu QR, Bhattacharjee P, Iyer MR, Xi ZX.   +9 more
europepmc   +1 more source

In‐Mold Wettability Patterning of Microfluidic Devices Without Back‐End Surface Modification

Chemistry–Methods, Volume 6, Issue 6, June 2026.
This study demonstrates in‐mold wettability patterning of microfluidic devices, eliminating the need for post‐fabrication surface modification to define hydrophilic and hydrophobic regions. The new approach enables efficient droplet seeding in hydrophilic‐in‐hydrophobic well arrays and selective wettability of microchannels in fluidic devices.
Reza Zandi Shafagh, Javad Kaveh, Volker M. Lauschke   +2 more
wiley   +1 more source

Mu Opioid Receptor mRNA and Protein Localization Across the Rat and Mouse Habenula

Journal of Comparative Neurology, Volume 534, Issue 6, June 2026.
Mu opioid receptor (MOR) mRNA was detected with RNAscope in situ hybridization for Oprm1 and protein was detected with immunocytochemistry to map the distributions across the anterior‐posterior extent of the rat and mouse habenula. Expression distribution was also characterized in a transgenic reporter mouse line (Oprm1‐Venus/Venus) as an additional ...
Aashka K. Popat, Rhiana C. Simon, Beatriz B. Aoyama, Ahana Wokhlu, Aliza T. Ehrlich, Corey C. Harwell, Elyssa B. Margolis   +6 more
wiley   +1 more source

Upregulated PKM2 Protects Dopaminergic Neurons From Oxidative Damage Through Nrf2 Transactivation in an MPTP‐Induced Mouse Model of Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Oxidative stress induced by MPTP promotes hnRNP A1/A2–dependent alternative splicing toward PKM2 in dopaminergic neurons. Elevated PKM2 transactivates Nrf2, enhances antioxidant gene expression, and protects neurons from oxidative damage and degeneration.
Meng Mei, Qian‐qian Miao, Meng‐ke Li, Hao‐ran Wang, Jian‐hua Ding, Gang Hu, Yao Wei   +6 more
wiley   +1 more source

Zebrafish Embryos to Profile Nano(bio)materials: A Modular Platform for Developmental Toxicity, Neurotoxicity, and Inflammation‐Regeneration Assays

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract Zebrafish embryos provide a rapid, low‐cost in vivo platform to profile the developmental, neurotoxic, and immunomodulatory effects of engineered nano(bio)materials within a single vertebrate system. This article presents a modular workflow that integrates standardized fish embryo acute toxicity (FET) testing, chemically assisted ...
Cinzia Bragato, Alessandra Lama, Greta Carbone Faccin, Johan George Varghese, Rossella Bengalli, Patrizia Bonfanti, Anita Colombo, Maurizio Gualtieri, Paride Mantecca   +8 more
wiley   +1 more source

Efficient Gene Expression System in Medaka Embryos Enables Functional Characterization of nt5c1a Paralogs Involved in Inosine Monophosphate Metabolism

genesis, Volume 64, Issue 3, June 2026.
ABSTRACT Optimizing transient expression systems in fish embryos is crucial for rapid gene function analysis. Here, we established an efficient system in medaka (Oryzias latipes) embryos by evaluating nucleic acid type and injection site. Our results revealed that injecting the elongation factor 1αA (ef1αA) promoter‐driven plasmid into the yolk yielded
Yu Murakami, Tomohisa Horibe, Masashi Ando, Toru Kobayashi   +3 more
wiley   +1 more source