Results 191 to 200 of about 23,889 (290)

Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal, Sarah Alvi, Fatima Humayune, Hasan Mujtaba, Shahzad Ahmad, Shazia Iqbal, Muhammad Farooq Umer   +6 more
wiley   +1 more source

The role of the dorsomedial hypothalamus in the cardiogenic sympathetic reflex in the Sprague Dawley rat. [PDF]

Front Physiol
Zahner MR, Hillard KJ, Chandley MC.
europepmc   +1 more source

Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A

Phytotherapy Research, Volume 40, Issue 5, Page 2710-2729, May 2026.
ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen, Xinghong Zhou, Yanting You, Jieyu Chen, Baizhao Peng, Yijian Deng, Shuai Ji, Ying Yang, Xiaohu Chen, Huaxi Liu, Shuxuan Yang, Hiu Yee Kwan, Wen Jin, Lei Zhang, Yuegang Wang, Xiaoshan Zhao, Yanyan Liu   +16 more
wiley   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, Volume 36, Issue 3, May 2026.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Control of Blood Pressure Variability Across Behavioral States by Brainstem Adrenergic Neurons. [PDF]

Circ Res
Souza GMPR, Thakkalapally H, Berry FE, Wisniewski LF, Atongazi UM, Stornetta DS, Abbott SBG.   +6 more
europepmc   +1 more source

Microinjection patent granted [PDF]

Nature, 1989
openaire   +1 more source

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling

Cell Proliferation, Volume 59, Issue 5, May 2026.
This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha   +9 more
wiley   +1 more source

Lumbar spinal Shox2 interneurons receive monosynaptic excitatory input from the lateral paragigantocellular nucleus in mouse. [PDF]

iScience
Singh S, Yao L, Dougherty KJ.
europepmc   +1 more source

The Tracy Technique: A Systems‐Based Paradigm Shift in Upper Face Neurotoxin Treatment

Journal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Background The Tracy Technique is a novel systems‐based method for upper face neurotoxin treatment. It challenges the traditional area‐based model by approaching the frontalis, glabella, and orbicularis oculi as a single dynamic complex. Objective To describe the anatomical rationale and clinical application of the Tracy Technique and its ...
Benjamin Tracy, Kylie Moe
wiley   +1 more source

Automation in microinjection for zebrafish pericardial space with image-based motion control and batch agarose microplate. [PDF]

PLoS One
Lee HJ, Lee HK, Lee SW, Son YW, Shin JN, Kim S.   +5 more
europepmc   +1 more source