Results 191 to 200 of about 18,274 (287)

Morinda Officinalis Oligosaccharides Alleviate Post‐Stroke Depression‐Like Behaviors Alongside Increased Gut Microbial Diversity and Butyrate Levels and Reduced Hippocampal Pla2g4a Expression

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
The mechanism by which MOO alleviates PSD in mice involves remodeling the gut microbiota to increase butyrate, thereby repairing the intestinal barrier and the blood–brain barrier. MOO and butyrate downregulate the hippocampal neuroinflammatory target Pla2g4a, while hippocampal overexpression of Pla2g4a counteracts the antidepressant effects of ...
Hui Ma, Yue Chen, Xinzhou Deng, Xuan Fang, Wenhui Xiao, Qian Long, Lu Du, Fuze Du, Haonan Chen, Yan Wang, Bo Gao, Xin Qiao   +11 more
wiley   +1 more source

Cardiovascular effects of ventrolateral periaqueductal gray (vlPAG) AT1 receptors in normotensive and hemorrhagic rats. [PDF]

Iran J Basic Med Sci
Hamounpeyma E, Mohebbati R, Shafei MN.
europepmc   +1 more source

An Orthotopic Xenograft Model for Preclinical Evaluation of CAR T Cell Therapy in Glioblastoma

Current Protocols, Volume 6, Issue 11, November 2026.
Abstract Glioblastoma (GBM) is the most lethal primary brain tumor in adults, and despite intensive research efforts, effective therapeutic breakthroughs remain elusive. Consequently, the standard of care has remained largely unchanged for nearly 30 years, underscoring the need for robust preclinical models to evaluate experimental therapies.
Julian Hübner, Rhonda McFleder, Chi Wang Ip, Miriam Alb, Hermann Einsele, Michael Hudecek, Thomas Nerreter   +6 more
wiley   +1 more source

Biosome Therapy for Androgenetic Alopecia in a Patient With Incomplete Response to Minoxidil and Finasteride: A Case Report. [PDF]

Clin Case Rep
Almashali M.
europepmc   +1 more source

Piezo1‐mediated unfolded protein response in goblet cells regulates intestinal mucus barrier homeostasis through the Ca2+–IRE1α–XBP1 pathway

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This study demonstrates that activation of Piezo1 channels in goblet cells by intestinal mechanical stimulation modulates ER calcium homeostasis via calcium ion (Ca2+) flux, which in turn regulates Mucin2 production and synthesis through the IRE1α‐XBP1. Intraperitoneal administration of Yoda1 alleviates mucus barrier impairment in DSS/WAS‐treated mice.
Jiandi Wu, Shaotong Wang, Zhe Wang, Jianhua Fang, Xueyan Li, Qingqing Zhang, Yan Dai, Wenjing Tian, Yize Ma, Gangping Li, Lei Zhang, Yudong Jiang, Xiaohua Hou, Jun Song   +13 more
wiley   +1 more source

Nitrergic neurotransmission within the lateral hypothalamus modulates cardiovascular responses to stress in rats. [PDF]

Pflugers Arch
Silva GA, Reis-Silva LL, Gomes-de-Souza L, Tavares LRR, Barretto-de-Souza L, Pelarin V, Crestani CC.   +6 more
europepmc   +1 more source

Obsessive–Compulsive Disorder: Comorbidity, Biomarkers, Circuits, and Treatment Strategies

MedComm, Volume 7, Issue 11, November 2026.
OCD has a high comorbidity with other psychiatric conditions, among which anxiety is the most frequent one. The shared genetic biomarkers and common neural circuits underlying the co‐occurrence of OCD and anxiety pave a new path for understanding the pathogenic mechanism of OCD and suggest tailored and integrative treatment therapies for OCD from the ...
Xiao‐Yang Zhang, Zi‐Hao Li, Li‐Ping Shen, Bing‐Qing Kong, Qi‐Peng Zhang, Ya Ke, Juan Tu, Fei Wang, Wing‐Ho Yung, Jing‐Ning Zhu   +9 more
wiley   +1 more source

Brain CB2 receptor: a new target in medication development for treating opioid use disorder in rodents. [PDF]

Mol Psychiatry
Soler-Cedeño O, Zhang HY, Xiong E, Bi GH, Alton H, Maras M, Liu QR, Bhattacharjee P, Iyer MR, Xi ZX.   +9 more
europepmc   +1 more source

Long Non‐Coding RNAs: Key Regulators of Economic Traits in Livestock From Mechanisms to Breeding Applications

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Long non‐coding RNAs (lncRNAs) act as key regulators of economically important traits in livestock through diverse mechanisms including ceRNA networks, epigenetic regulation (X‐inactivation and imprinting) and liquid–liquid phase separation (LLPS).
Keyvan Khani, Mohammad Taher Harkinezhad, Rahimeh Sepehri   +2 more
wiley   +1 more source

Spinal Cord CELF4 in Chronic Constriction Injury-Induced Neuropathic Pain: Association with TRPV1 and COX-2 Expression. [PDF]

J Mol Neurosci
Kong G, Tan R, Zeng X, Zhang H, Zhang B, Yu J, Xie R.   +6 more
europepmc   +1 more source