Results 81 to 90 of about 23,889 (290)
The nucleus retroambiguus control of respiration [PDF]
, 2009 The role of the nucleus retroambiguus (NRA) in the context of respiration control has been subject of debate for considerable time. To solve this problem, we chemically (using d, L-homocysteic acid) stimulated the NRA in unanesthetized precollicularly ...
Holstege, Gert, Subramanian, Hari H.
core +2 more sources
Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila
Advanced Science, EarlyView.Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu +7 more
wiley +1 more source
Nitric oxide modulates the cardiovascular effects elicited by acetylcholine in the NTS of awake rats [PDF]
, 2008 da Silva LG, Rodrigues Dias AC, Furlan E, Colombari E. Nitric oxide modulates the cardiovascular effects elicited by acetylcholine in the NTS of awake rats. Am J Physiol Regul Integr Comp Physiol 295: R1774-R1781, 2008. First published September 24, 2008;
Colombari, Eduardo +3 more
core +1 more source
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Mapping a Novel Hedonic Hotspot in the Orbitofrontal Cortex [PDF]
, 2014 Honors (Bachelor's)PsychologyUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/107703/1/mikewkh ...
Wu, Kuan Hua
core
Effect of scopolamine-based amnesia on the number of astrocytes in the rat's hippocampus [PDF]
, 2012 As neuron-astrocyte interactions play a crucial role in the adult brain, it is thought that astrocytes support learning and memory through specific mechanisms.
Azami, N.S. +2 more
core +1 more source
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
Heliyon, 2019 Background: Microinjections, lesions, viral-mediated gene transfer, or designer receptors exclusively activated by designer drugs (DREADDs) can identify brain signaling pathways and their pharmacology in research animals. Genetically modified animals are
Shirisha Meda +5 more
doaj +1 more source
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Mesotherapy for Melasma – An Updated Review
Journal of Pharmacy and Bioallied SciencesMesotherapy is a popular novel therapeutic modality that delivers intradermal or subcutaneous microinjections of pharmaceutical compounds. Although this novel treatment method is used commonly in aesthetic dermatology, there is little information about ...
Kashikar Yash +4 more
doaj +1 more source