Results 81 to 90 of about 18,274 (287)
Heliyon, 2019 Background: Microinjections, lesions, viral-mediated gene transfer, or designer receptors exclusively activated by designer drugs (DREADDs) can identify brain signaling pathways and their pharmacology in research animals. Genetically modified animals are
Shirisha Meda +5 more
doaj +1 more source
Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
Advanced Science, EarlyView.Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi +8 more
wiley +1 more source
The use of microinjections aginst bark beetles on spruce in forestry praxis
, 2020 The report summarizes the results of toxicity tests of various bioinsecticides and their field applications to spruce trees via microinjections to protect stands against the spruce bark beetle, Ips ...
Doležal, Petr
core
Advanced Science, EarlyView.Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang +15 more
wiley +1 more source
Mesotherapy for Melasma – An Updated Review
Journal of Pharmacy and Bioallied SciencesMesotherapy is a popular novel therapeutic modality that delivers intradermal or subcutaneous microinjections of pharmaceutical compounds. Although this novel treatment method is used commonly in aesthetic dermatology, there is little information about ...
Kashikar Yash +4 more
doaj +1 more source
Pesquisa Veterinária Brasileira, 2019 : Extensive literature is available about the intrinsic denervation of segments of the digestive tube through the application of CB in the serosa of the viscera.
Juliana O. Ribeiro +7 more
doaj +1 more source
Towards the Automation of Embryonic Stem Cell Microinjections into Blastocysts
, 2009 The purpose of the research has been to increase the consistency and efficiency rates of blastocyst microinjections through automation. The research involved the design, implementation, and evaluation of a novel biomanipulation system that is a test-bed
Mattos, Leonardo Serra
core
A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior
Advanced Science, EarlyView.Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li +12 more
wiley +1 more source
Motor tics evoked by striatal disinhibition in the rat
Frontiers in Systems Neuroscience, 2013 Motor tics are sudden, brief, repetitive movements that constitute the main symptom of Tourette syndrome (TS). Multiple lines of evidence suggest the involvement of the cortico-basal ganglia system, and in particular the basal ganglia input structure ...
Maya eBronfeld +3 more
doaj +1 more source