Results 101 to 110 of about 36,831 (386)

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, EarlyView.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho, Yunyoung Choi, Yerim Jang, Hyejeong Seong   +3 more
wiley   +1 more source

Microneedles for Drug Delivery [PDF]

Pharmaceutical Research, 2010
The theme section highlighted in this issue of Pharmaceutical Research provides a snapshot of the latest information on today’s microneedle research and development, predominately in transdermal applications. Fifteen original papers from academia and industry cover research and development of microneedles from concept to human clinical studies and ...
openaire   +3 more sources

The Use of a Pressure-Indicating Sensor Film to Provide Feedback upon Hydrogel-Forming Microneedle Array Self-Application In Vivo [PDF]

, 2016
PURPOSE: To evaluate the combination of a pressure-indicating sensor film with hydrogel-forming microneedle arrays, as a method of feedback to confirm MN insertion in vivo. METHODS: Pilot in vitro insertion studies were conducted using a Texture Analyser
Barry, Johanne G., Donnelly, Ryan F., Hanna, Lezley-Anne, McAlister, Emma, O' Neill, Shannon, Quinn, Helen L., Vicente-Perez, Eva M.   +6 more
core   +1 more source

Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy

Advanced Healthcare Materials, EarlyView.
This review explores two major types of closed‐loop therapeutic systems: self‐sustained and externally triggered. It highlights recent advances in stimuli‐responsive materials, integrated bioelectronics, and data‐driven control strategies, offering insight into emerging strategies for personalized, responsive drug delivery.
Yixuan Leng, Rujie Sun
wiley   +1 more source

Wireless sEMG System with a Microneedle-Based High-Density Electrode Array on a Flexible Substrate [PDF]

, 2019
Surface electromyography (sEMG) signals reflect muscle contraction and hence, can provide information regarding a user's movement intention. High-density sEMG systems have been proposed to measure muscle activity in small areas and to estimate ...
CHA, KYOUNG JE, CHUNG, WAN KYUN, GANG, YONG GU, KIM, DONG SUNG, KIM, MINJAE   +4 more
core   +1 more source

Dissolving Microneedle for Maintaining the Integrity of HPV Virus‐Like Particles Enabling Durable Sterile Protection Across Various Mucosal Tissues

Advanced Healthcare Materials, EarlyView.
A novel dissolving microneedle platform preserves HPV virus‐like particle (VLP) immunogenicity by maintaining structural integrity, crucial for eliciting potent immune responses. Buccal administration induces robust immune response, high neutralizing antibody titers, and durable sterile protection across oral and vaginal mucosal sites.
Hyemi Kim, Inhyuk Hwang, Juhee Seo, Chaiwon Kim, In‐Jeong Choi, Miran Kang, Min‐Seok Rha, Youngjae Hong, Jooyoung Kim, Seung‐Ki Baek, Jung‐Hwan Park, Hyung‐Ju Cho, Kihyuck Kwak   +12 more
wiley   +1 more source

Anti-arthritic effects of microneedling with bee venom gel

Journal of Traditional Chinese Medical Sciences, 2016
Objective: To combine with transdermal drug delivery using microneedle to simulate the bee venom therapy to evaluate the permeation of bee venom gel. Methods: In this study, the sodium urate and LPS were used on rats and mice to construct the model.
Mengdi Zhao, Jie Bai, Yang Lu, Shouying Du, Kexin Shang, Pengyue Li, Liu Yang, Boyu Dong, Ning Tan   +8 more
doaj   +1 more source

Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment

Scientific Reports, 2021
Delivering bioactive compounds into skin tissue has long been a challenge. Using ex vivo porcine and rat skins, here we demonstrate that a detachable dissolvable microneedle (DDMN) array, a special dissolvable microneedle that allows needle detachment ...
Pritsana Sawutdeechaikul, Silada Kanokrungsee, Thanyapat Sahaspot, Kamonwan Thadvibun, Wijit Banlunara, Benchaphorn Limcharoen, Titiporn Sansureerungsikul, Teeranut Rutwaree, Miranda Oungeun, Supason Wanichwecharungruang   +9 more
doaj   +1 more source

Safety, tolerability and efficacy of intradermal rabies immunization with DebioJect™. [PDF]

, 2017
In a single-center study, 66 healthy volunteers aged between 18 and 50years were randomized to be immunized against rabies with three different injection routes: intradermal with DebioJect™ (IDJ), standard intradermal with classical needle (IDS), also ...
Bart, P.A., Cachemaille, A., Hart, K., Liberman, J., Pantaleo, G., Piveteau, L.D., Ramaniraka, N., Rettby, N., Vescovo, P., Zanoni, R.   +9 more
core   +2 more sources

Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin

Advanced Healthcare Materials, EarlyView.
Rolling ultraminiaturized microneedle spheres (RUMS), created via two‐photon polymerization, unlock effective and painless topical delivery of messenger RNA (mRNA) and drugs through the skin. By gently forming thousands of microscopic pores, RUMS boost skin permeability by up to 100‐fold.
Theocharis Nikiforos Iordanidis, Argyris Spyrou, Samantha Roudi, Fredrik J. Swartling, Göran Stemme, Samir EL Andaloussi, Niclas Roxhed   +6 more
wiley   +1 more source