Results 111 to 120 of about 36,831 (386)

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

Advanced Healthcare Materials, EarlyView.
This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani, Aaron R. J. Hutton, Peter E. McKenna, Eneko Larrañeta, Ryan F. Donnelly   +4 more
wiley   +1 more source

Multifunctional polysaccharide composited microneedle for oral ulcers healing

Materials Today Bio, 2023
Oral ulcers have periodicity and recurrence, and the etiology and causative mechanisms remain unclear; therefore, it is difficult to treat oral ulcers effectively.
Yiyu Zeng, Yijun Gao, Liming He, Wenhui Ge, Junhui Liu, Yi Yu, Xiaoyan Xie   +6 more
doaj  

Polymer multilayer tattooing for enhanced DNA vaccination [PDF]

, 2012
DNA vaccines have many potential benefits but have failed to generate robust immune responses in humans. Recently, methods such as in vivo electroporation have demonstrated improved performance, but an optimal strategy for safe, reproducible, and pain ...
Barouch, Dan H., DeMuth, Peter Charles, Hammond, Paula T., Huang, Bonnie, Irvine, Darrell J., Kramer, Joshua A., Miller, Andrew D., Min, Younjin   +7 more
core   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Polymer substrates with microneedles for epidermis injection [PDF]

, 2009
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2009.Cataloged from PDF version of thesis.Includes bibliographical references (p.
Pavlish, John R
core  

Hydrodynamic gene delivery in human skin using a hollow microneedle device [PDF]

, 2017
Microneedle devices have been proposed as a minimally invasive delivery system for the intradermal administration of nucleic acids, both plasmid DNA (pDNA) and siRNA, to treat localised disease or provide vaccination.
Birchall, J. C., Coulman, S. A., Dayan, C., Dul, M., Henri, S., Kochba, E., Levin, Y., Malissen, B., O'Mahony, Conor, Porta, P., Serve, J., Stefanidou, M., Wong, F. S.   +12 more
core   +4 more sources

Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

Advanced Materials, EarlyView.
This article summarizes significant technological advancements in materials, photonic devices, and bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, and on‐skin health monitoring.
Seunghyeb Ban, Hoon Yi, Jaejin Park, Yunuo Huang, Ki Jun Yu, Woon‐Hong Yeo   +5 more
wiley   +1 more source

Dissolving microneedles for DNA vaccination: Improving functionality via polymer characterisation and RALA complexation [PDF]

, 2016
DNA vaccination holds the potential to treat or prevent nearly any immunogenic disease, including cancer. To date, these vaccines have demonstrated limited immunogenicity in vivo due to the absence of a suitable delivery system which can protect DNA from
Ali, Ahlam A., Cole, Grace, Donnelly, Ryan F., McBride, John W., McCaffrey, Joanne, McCarthy, Helen O., McCrudden, Cian M., Vicente-Perez, Eva M.   +7 more
core   +1 more source

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

Advanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian   +3 more
wiley   +1 more source

Stabilization of influenza vaccine enhances protection by microneedle delivery in the mouse skin.

PLoS ONE, 2009
BackgroundSimple and effective vaccine administration is particularly important for annually recommended influenza vaccination. We hypothesized that vaccine delivery to the skin using a patch containing vaccine-coated microneedles could be an attractive ...
Fu-Shi Quan, Yeu-Chun Kim, Dae-Goon Yoo, Richard W Compans, Mark R Prausnitz, Sang-Moo Kang   +5 more
doaj   +1 more source