Results 51 to 60 of about 12,393 (293)

A Data Driven Review of In Vitro Electrical and Mechanical Stimulation for Post‐Acute Phase Wound Healing

Advanced Healthcare Materials, EarlyView.
This review examines how in vitro electrical and mechanical stimulation modulates wound healing in fibroblasts and keratinocytes. Analyzing over 560 experimental data points, we relate stimulation parameters to proliferation and migration outcomes, evaluate platform designs, and highlight the need for multi‐parameter optimization to advance targeted ...
Matthew K. Burgess, Ellen F. Marsh, Veronica M. Lucian, Malavika Nair   +3 more
wiley   +1 more source

Sugar-Triggered Burst Drug Releasing Poly-Lactic Acid (PLA) Microneedles and Its Fabrication Based on Solvent-Casting Approach

Pharmaceutics, 2022
Microneedles have emerged as a novel transdermal delivery tool that enables the delivery of various products such as drugs, vaccines, or cosmetic ingredients. Although the demand for solid microneedles composed of biocompatible polymer is increasing, the
Seongsu Kang, Ji Eun Song, Seung-Hyun Jun, Sun-Gyoo Park, Nae-Gyu Kang   +4 more
doaj   +1 more source

Epidermal Patch Technologies for Integrated Healthcare and Infection Management

Advanced Healthcare Materials, EarlyView.
Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang, Atakan Tevlek, Pawel L. Urban, Boaz Mizrahi, Onome Ejeromedoghene, Roshan Deen, Yuanjing Lin, Jagan Mohan Dodda   +7 more
wiley   +1 more source

Adaptable Covalent Organic Framework‐Hydrogel Microneedles for Glucose‐Responsive Isoliquiritigenin Delivery in Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
We develop a covalent organic framework‐loaded Traditional Chinese Medicine monomer nanodrug delivery system (ISL@bCOF) via boron‐oxygen bonds, a smart response to glucose for delivering AI‐driven isoliquiritigenin (ISL) targeting ZBP1. This dynamic release mechanism, combined with transdermal delivery technology via potent microneedles, can modulate ...
Menghan Zhou, Zongjie Hu, Xiuwen Li, Huaman Geng, Yang Liu, Yajie Wang, Yunshu Yang, Guangdong Zhou, Yujie Hua, Di Wang   +9 more
wiley   +1 more source

Research on conductive polymer microneedles with adjustable dissolution rate

AIP Advances
Dissolvable polymeric microneedles have gained significant attention in recent years as a promising transdermal drug delivery method due to their simple fabrication and lack of medical waste after use.
Wenkai Wang, Yanhong Liang, Xiaoxiao Yan, Gang Tang, Yuwen Li, Zhibiao Li   +5 more
doaj   +1 more source

Microneedle-Based Vaccines [PDF]

, 2009
The threat of pandemic influenza and other public health needs motivate the development of better vaccine delivery systems. To address this need, microneedles have been developed as micron-scale needles fabricated using low-cost manufacturing methods that administer vaccine into the skin using a simple device that may be suitable for self ...
Mark R, Prausnitz, John A, Mikszta, Michel, Cormier, Alexander K, Andrianov   +3 more
openaire   +2 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

TMPTA Microneedles of Different Shapes.

, 2016
A) TMPTA microneedles of aspect ratio 2, 3, and 4 (left to right). 1000μm tall TMPTA microneedles with spacing of B) 0.5 base widths and C) 1.5 base widths.
J. Christopher Luft (742626), Joseph M. DeSimone (402094), John R. Tumbleston (1314030), Alexander Ermoshkin (3109683), David Shirvanyants (2060650), Katherine A. Moga (3109686), Sue J. Mecham (1682983), Cassie L. Caudill (3109680), Ashley R. Johnson (3109689), Cameron J. Bloomquist (3109692)   +9 more
core   +1 more source

Digital Microneedles for Multiplexed Transdermal Sensing via Fluorescent QR Codes

Advanced Materials, EarlyView.
Digital fluorescent microneedles encode biochemical information in skin into scannable QR codes through threshold‐activated probes that generate binary on/off signals. By transforming analog fluorescence into discrete digital patterns, this platform enables calibration‐free, multiplexed transdermal sensing of physiologically relevant biomarkers ...
Farbod Abazar, Shahrokh Vahabi, Elena Bellotti, Martina Corsi, Irene Nocera, Paola Orlandi, Guido Bocci, Giuseppe Barillaro   +7 more
wiley   +1 more source

A critical review of advances and challenges in microinjection moulding of polymeric microneedles [PDF]

Microneedles are an innovative alternative to hypodermic needles for delivering vaccines and therapeutic agents and sampling biofluids for point-of-care diagnostics.
Prewett, Philip D., Rad, Zahra Faraij, Prewett, Phil, Mushtaq, Asim, Saifullah, Khaled Mohammed, Davies, Graham J., Davies, Graham, Faraji Rad, Zahra, Azarikhah, Pouria   +8 more
core   +1 more source