Results 61 to 70 of about 33,747 (400)
Frontiers in Bioengineering and Biotechnology, 2018 In this study we present the fabrication of multilayer microneedles with circular obelisk and beveled-circular obelisk geometries, which have potential applications in implantable drug delivery devices.
Min Jung Kim +7 more
doaj +1 more source
Transdermal vaccination via 3D-printed microneedles induces potent humoral and cellular immunity
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Vaccination is essential for combatting emerging epidemics and pandemics. Microneedle patches designed to precisely deliver cargos into the intradermal space, rich in immune cells, provide a noninvasive and self-applicable vaccination ...
Cassie L. Caudill +7 more
semanticscholar +1 more source
Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates. [PDF]
, 2020 Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery and ...
Chung, Sook Hyun +7 more
core
Composite Dissolving Microneedles for Coordinated Control of Antigen and Adjuvant Delivery Kinetics in Transcutaneous Vaccination [PDF]
, 2012 Transcutaneous administration has the potential to improve therapeutics delivery, providing an approach that is safer and more convenient than traditional alternatives, while offering the opportunity for improved therapeutic efficacy through sustained ...
Ai-Ling, Michelle Lim +4 more
core +1 more source
Microneedles’ Device: Design, Fabrication, and Applications
MacromolThe delivery of therapeutical molecules through the skin, particularly to its deeper layers, is impaired due to the stratum corneum layer, which acts as a barrier to foreign substances. Thus, for the past years, scientists have focused on the development
Cristiana Oliveira +4 more
semanticscholar +1 more source
Microneedles in Drug Delivery: Progress and Challenges
Micromachines, 2021 In recent years, an innovative transdermal delivery technology has attracted great interest for its ability to distribute therapeutics and cosmeceuticals for several applications, including vaccines, drugs, and biomolecules for skin-related problems. The
Muhammet Avcil, Ayhan Çelik
semanticscholar +1 more source
Determination of parameters for successful spray coating of silicon microneedle arrays [PDF]
, 2011 Coated microneedle patches have demonstrated potential for effective, minimally invasive, drug and vaccine delivery. To facilitate cost-effective, industrial-scale production of coated microneedle patches, a continuous coating method which utilises ...
Crean, Abina M. +5 more
core +1 more source
Journal of Nanobiotechnology, 2022 Tumor killing and wound healing are two complementary and influential processes during the treatment of melanoma. Herein, a two-layered microneedle platform was developed with bifunctional effect of chemo-photothermal synergistic melanoma therapy and ...
Yue Shan +4 more
semanticscholar +1 more source
Polymer multilayer tattooing for enhanced DNA vaccination [PDF]
, 2012 DNA vaccines have many potential benefits but have failed to generate robust immune responses in humans. Recently, methods such as in vivo electroporation have demonstrated improved performance, but an optimal strategy for safe, reproducible, and pain ...
Barouch, Dan H. +7 more
core +1 more source
Separable arrowhead microneedles [PDF]
Journal of Controlled Release, 2011 Hypodermic needles cause pain and bleeding, produce biohazardous sharp waste and require trained personnel. To address these issues, we introduce separable arrowhead microneedles that rapidly and painlessly deliver drugs and vaccines to the skin. These needles are featured by micron-size sharp tips mounted on blunt shafts.
Leonard Y. Chu, Mark R. Prausnitz
openaire +3 more sources