Results 161 to 170 of about 24,177 (264)

MicroNucML: A machine learning approach for micronuclei segmentation and the refinement of nuclei-micronuclei relationships

Abstract Micronuclei (MN) are structures containing small fragments of DNA, arising from mitotic errors or failed DNA repair attempts. Therefore, MN serve as markers of genomic instability and are typically quantified either manually or through threshold-based methods, which can be tedious and inaccurate, leading to varying degrees of ...
Yukai Wang, Nadejda B. Boev, Ulises O. Garcia, Kate M. MacDonald, Shane M. Harding, Sushant Kumar   +5 more
openaire   +1 more source

Canine Urothelial DNA Mutations Are Not Associated With Total Trihalomethanes Concentrations in Municipal Drinking Water

Veterinary and Comparative Oncology, Volume 24, Issue 2, Page 363-369, June 2026.
ABSTRACT Contaminants in municipal drinking water, specifically total trihalomethanes (TTHMs), are mutagenic. Exposures to TTHMs have been associated with urothelial carcinoma (UC) in both people and dogs. Mutations in the BRAF gene and other genomic copy number aberrations detected in voided urothelial cells with commercial CADET BRAF and BRAF‐PLUS ...
Janice O'Brien, Samantha L. Braman, Jennifer Willcox, Phillip Wang, Daniel Gerrity, Audrey Ruple, Lauren A. Trepanier   +6 more
wiley   +1 more source

Genotoxic potential of Dianthus superbus var. superbus and Petasites paradoxus (Retz.) Baumg. methanolic extracts in Chinese hamster ovary cells. [PDF]

Sci Rep
Al-Naqeb G, De Giuseppe R, Kalmpourtzidou A, Avesani L, Cena H.   +4 more
europepmc   +1 more source

Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from the non‐genetically modified Aspergillus niger strain AE‐GN

EFSA Journal, Volume 24, Issue 6, June 2026.
Abstract The food enzyme glucan 1,4‐α‐glucosidase (4‐α‐d‐glucan α‐glucohydrolase; EC 3.2.1.3) is produced with the non‐genetically modified Aspergillus niger strain AE‐GN by Amano Enzyme Inc. The food enzyme was considered free from viable cells of the production organism. It is intended to be used in 13 food manufacturing processes.
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Cristina Andreoli, Andrea Terron, Daniele Cavanna, Natalia Kovalkovicova, Jaime Aguilera, Magdalena Andryszkiewicz, Rita Ferreira de Sousa, Yi Liu   +20 more
wiley   +1 more source

Safety evaluation of a food enzyme containing oryzin and leucyl aminopeptidase activities and a heat‐treated food enzyme containing only leucyl aminopeptidase activity from the non‐genetically modified Aspergillus sp. strain FL 72‐230

EFSA Journal, Volume 24, Issue 6, June 2026.
Abstract This assessment addressed two food enzymes produced with the non‐genetically modified microorganism Aspergillus sp. strain FL 72‐230 by Shin Nihon Chemical Co., Ltd. The native food enzyme contains leucyl aminopeptidase (EC 3.4.11.1) and oryzin (EC 3.4.21.63) activities.
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Cristina Andreoli, Andrea Terron, Daniele Cavanna, Jaime Aguilera, Magdalena Andryszkiewicz, Natalia Kovalkovicova, Silvia Peluso, Rita Ferreira de Sousa, Yi Liu   +21 more
wiley   +1 more source

Integrating Adaptive Responses Into Hormesis: δ Plot Analysis of the Yonezawa Effect in the Micronucleus Test. [PDF]

Dose Response
Sutou S, Koeda A, Komatsu K, Shiragiku T, Seki H, Kudo T.   +5 more
europepmc   +1 more source

Safety evaluation of the food enzyme bacillolysin from the non‐genetically modified Bacillus amyloliquefaciens strain BP

EFSA Journal, Volume 24, Issue 6, June 2026.
Abstract The food enzyme bacillolysin (EC 3.4.24.28) is produced with the non‐genetically modified Bacillus amyloliquefaciens strain BP by HBI Enzymes Inc. The food enzyme is intended to be used in eight food manufacturing processes. Since residual amounts of total organic solids (TOS) are removed in one process, dietary exposure was calculated for the
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Simone Lunardi, Magdalena Andryszkiewicz, Daniele Cavanna, Ana Criado, Yi Liu   +17 more
wiley   +1 more source

Barrier-to-autointegration factor protects against the cGAS-STING response to chromatin bridges. [PDF]

PLoS Genet
Chastant L, Normandin K, El-Mortada F, Servant MJ, Archambault V.   +4 more
europepmc   +1 more source

Automated Micronuclei Detection in Exfoliated Oral Epithelial Cells of Smokers using Image Analysing Softwares

Micronuclei assay yields an excellent path to monitor individuals or populations exposed to mutagenic, genotoxic or teratogenic events. Micronuclei are small nucleic structures formed due to the deposition of nuclear envelopes around lagging chromosomes ...
Saini, Mukul, Alva, Saiprasad, Shetty, Sanjana, Augustine, Dominic, SV, Sowmya   +4 more
core  

Revised safety evaluation of the food enzyme catalase from the non‐genetically modified Aspergillus niger strain CTS2093

EFSA Journal, Volume 24, Issue 6, June 2026.
Abstract The food enzyme catalase (hydrogen‐peroxide:hydrogen‐peroxide oxidoreductase; EC 1.11.1.6) is produced with the non‐genetically modified Aspergillus niger strain CTS2093 by Shin Nihon Chemical Co., Ltd. In a previous evaluation, the Panel could not exclude safety concerns due to an insufficient margin of exposure (MoE).
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Cristina Andreoli, Andrea Terron, Ana Criado, Jaime Aguilera, Magdalena Andryszkiewicz, Yi Liu   +18 more
wiley   +1 more source