Results 91 to 100 of about 48,051 (246)
A high-throughput in vivo micronucleus assay for genome instability screening in mice
Nature Protocols, 2014 We describe a sensitive, robust, high-throughput method for quantifying the formation of micronuclei, markers of genome instability, in mouse erythrocytes. Micronuclei are whole chromosomes or chromosome segments that have been separated from the nucleus.
G. Balmus +5 more
semanticscholar +1 more source
Cancer Science, EarlyView.UV irradiation induces two major types of pyrimidine dimers, CPDs and 6–4PPs. Whereas 6–4PPs efficiently induce cell‐cycle arrest, CPDs do not and frequently persist into S phase. As a result, DSBs can arise in the presence of unrepaired CPDs after 6–4PPs have been repaired, increasing the risk of genomic instability.
Ken‐ichi Yoshioka +2 more
wiley +1 more source
Acta Scientiarum: Biological Sciences, 2018 Most changes in water bodies are result of human activities that have the potential to undermine the environmental integrity of aquatic ecosystems. Changes in genetic material can be evidenced by the frequency of nuclear abnormalities in fish blood cells,
Merieli Melo-Silva +5 more
doaj +1 more source
Buccal Micronucleus Cytome Assay- A Biomarker of Genotoxicity
, 2015 The buccal micronucleus cytome assay in exfoliated buccal cells is utilized as biomarkers for DNA damage, cell death and basal cell frequency. It offers great opportunity to evaluate genotoxicity by the way of quantifying mean frequencies of micronuclei,
A. Yadav, Shikha Jaggi
semanticscholar +1 more source
Cell Proliferation, EarlyView.In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar +5 more
wiley +1 more source
Utilização de roedores silvestres no biomonitoramento citogenetico in situ [PDF]
, 1997 Tese (doutorado) - Universidade de São Paulo, Instituto de ...
Bueno, Angela Maria de Souza
core
Micronucleus test using formalin-fixed rat glandular stomach and colon
, 2023 Background Genotoxicity in tissues other than hematopoietic tissues, such as the liver and gastrointestinal (GI) tract, is an important focus in the risk assessment of chemicals in humans. We previously developed a rat micronucleus test for the GI tract,
Emiko Okada +4 more
core +1 more source
, 2015 In the present study the potential toxic effect of prometryne herbicide was examined by investigating mitotic index, mitotic phase, chromosomal abnormalities, micronucleus frequency, 2C DNA content, and comet assay on the root tip cells of Allium cepa ...
M. Karaismailoğlu
semanticscholar +1 more source
Journal of Oral Pathology &Medicine, EarlyView.ABSTRACT Background Fanconi anemia (FA) is a rare genetic disorder predisposing patients to oral squamous cell carcinoma (OSCC). Hematopoietic stem cell transplantation (HSCT) corrects bone marrow failure but may increase the risk of malignancies. Exfoliative cytology and the micronucleus (MN) test provide noninvasive assessment of genomic instability.
Bárbara Soldatelli Ballardin +4 more
wiley +1 more source
The micronucleus assay in radiation accidents [PDF]
, 2009 The cytokinesis-block micronucleus assay in peripheral blood lymphocytes is a standardised and validated technique for biodosimetry. Automated scoring of micronuclei allows large scale applications as in population triage in case of radiation accidents ...
Vral, Anne, Thierens, Hubert
core