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Therapeutic potential of Brazilian medicinal plants and their metabolites. [PDF]

Genet Mol Biol
Serpeloni JM, Santos FVD, Tuttis K, Cólus IMS.   +3 more
europepmc   +1 more source

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The micronucleus test

Mutation Research - Environmental Mutagenesis and Related Subjects Including Methodology, 1975
The micronucleus test (m.t.) in vivo is a method devised primarily for screening chemicals for chromosome-breaking effects. The test substances are normally applied sub-acutely to small mammals, and the effect is read in direct smears from bone marrow. This testing procedure, developed by SCHMID and coworkers1~3~5~6 has a number of important advantages
W. Schmid
exaly   +4 more sources

Sampling times in micronucleus testing

Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 1992
A series of micronucleus inducers were evaluated in the mouse bone marrow micronucleus test to determine if a 72-h sampling time enhances the sensitivity for detecting genotoxic agents. Male and female Swiss albino mice were dosed once with 7,12- dimethylbenz[a]anthracene, 6-mercaptopurine, benzo[a]pyrene, benzene, cyclophosphamide, 2 ...
P, Vanparys, G, Deknudt, F, Vermeiren, M, Sysmans, R, Marsboom   +4 more
exaly   +3 more sources

The micronucleus test in piscine erythrocytes

Aquatic Toxicology, 2006
Cytogenetic assays on aquatic organisms are essential, as humans are exposed throughout their lifetime to several xenobiotics present in both the water and aquatic food. The micronucleus test showed to be a useful in vivo assay for genotoxicity testing. However, many aspects of its protocol need to be refined, knowledge of confounding factors should be
exaly   +3 more sources

Micronucleus Test (MNT)

2014
Mercury, one of the most widely diffused and hazardous organ-specific environmental contaminants, exists in a wide variety of physical and chemical states, each of which with unique characteristics of target organ specificity (Aleo et al. 2002). In nature the different forms of mercury include the metallic form, inorganic compounds, as well as alkyl ...
S. Nabi
openaire   +2 more sources

Micronucleus test and nuclear abnormality assay in zebrafish (Danio rerio): Past, present, and future trends.

Environmental Pollution, 2021
Nuclear abnormality (NA) assay in fish has been widely applied for toxicity risk assessment under field and laboratory conditions. The zebrafish (Danio rerio) has become a suitable model system for assessing the NA induced by pollutants.
Aryelle Canedo, L. W. O. de Jesus, Elisa Flávia Luiz Cardoso Bailão, T. L. Rocha   +3 more
semanticscholar   +1 more source

Micronucleus test in tadpole erythrocytes: Trends in studies and new paths.

Chemosphere, 2020
The micronucleus test has been applied for more than three decades in tadpoles, generating an early warning of environmental quality. In this study, we reviewed 48 articles on the micronucleus test in tadpoles, published between 1987 and 2018.
Marcelino Benvindo‐Souza, Eliane Andreia Santos Oliveira, R. A. Assis, Cirley Gomes Araújo Santos, R. E. Borges, Daniela de Melo e Silva, Lia Raquel de Souza Santos   +6 more
semanticscholar   +1 more source

Micronucleus Test Reveals Genotoxic Effects in Bats Associated with Agricultural Activity

Environmental Toxicology and Chemistry, 2020
Bats play a vital role in our ecosystems and economies as natural pest‐control agents, seed dispersers, and pollinators. Agricultural intensification, however, can impact bats foraging near crops, affecting the ecosystem services they provide.
N. Sandoval-Herrera, Jesusa Paz Castillo, L. G. Herrera Montalvo, Kenneth C Welch   +3 more
semanticscholar   +1 more source

The effect of benzene in the micronucleus test

Mutation Research/Genetic Toxicology, 1980
The potential cytogenetic effect of benzene was studied by means of the micronucleus test in developing erythrocytes of male and female mice at dosages ranging from 0.0625 to 2.0 ml/kg/day. Groups of mice were given two daily oral doses and sacrificed 6, 18, 24 or 48 h, or 5, 9 or 16 days after the last dose. The doses were given 24 h apart.
M, Hite, M, Pecharo, I, Smith, S, Thornton   +3 more
openaire   +2 more sources

Effect of erythropoietin on the micronucleus test

Environmental and Molecular Mutagenesis, 1989
AbstractThe micronucleus test is used widely as an in vivo short‐term assay for potential carcinogens. In the present study, results of the micronucleus test were affected by the rate of erythropoiesis in the bone marrow erythropoietin, a growth factor for the erythroblast, which was used to induce erythropoiesis.The highest frequency of micronucleated
Y, Suzuki, Y, Nagae, T, Ishikawa, Y, Watanabe, T, Nagashima, K, Matsukubo, H, Shimizu   +6 more
openaire   +2 more sources