Results 221 to 230 of about 13,742,305 (307)
Some of the next articles are maybe not open access.
The automated bone marrow micronucleus test
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1989A new technology is presented which offers high-quality slides enabling the fully automated scoring of large quantities of erythrocytic cells for micronuclei by computerized image analysis. The techniques are applicable to bone marrow specimens as well as to peripheral blood obtained from various species of laboratory animals as well as from man.
F, Romagna, C D, Staniforth
openaire +2 more sources
Statistical analysis of the micronucleus test
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1984Various statistical procedures are discussed to compare the incidence of micronucleated polychromatic erythrocytes between various treatment groups and a negative control. The effect of toxicity on the choice of statistical procedure is discussed. The procedure which is recommended is based on likelihood ratio tests comparing each dose group separately
G E, Amphlett, G F, Delow
openaire +2 more sources
Effect of erythropoietin on the micronucleus test
Environmental and Molecular Mutagenesis, 1989AbstractThe micronucleus test is used widely as an in vivo shortâterm assay for potential carcinogens. In the present study, results of the micronucleus test were affected by the rate of erythropoiesis in the bone marrow erythropoietin, a growth factor for the erythroblast, which was used to induce erythropoiesis.The highest frequency of micronucleated
Y, Suzuki +6 more
openaire +2 more sources
The micronucleus test with mouse spleen cells
Mutation Research Letters, 1983The results of this study show that the micronucleus test can be carried out with mouse spleen cells as well as with cells from bone marrow. Polychromatic erythrocytes occurred in the spleen at a frequency of about 9% of the whole spleen cells compared with about 13% in the bone marrow. 3 test compounds were used to compare the frequency of micronuclei
Y, Shindo +3 more
openaire +2 more sources
The micronucleus test in piscine erythrocytes
Aquatic Toxicology, 2006Cytogenetic assays on aquatic organisms are essential, as humans are exposed throughout their lifetime to several xenobiotics present in both the water and aquatic food. The micronucleus test showed to be a useful in vivo assay for genotoxicity testing. However, many aspects of its protocol need to be refined, knowledge of confounding factors should be
openaire +2 more sources
The micronucleus test: Statistical design and analysis
Mutation Research/Environmental Mutagenesis and Related Subjects, 1979Alternative statistical procedures are discussed which may be employed to compare the incidences among treatment groups of micronucleated polychromatic and normochromatic erythrocytes and their ratios. Comparison of incidences of micronucleated polychromatic erythrocytes using a sequential sampling strategy based on the negative binomial distribution ...
B E, Mackey, J T, MacGregor
openaire +2 more sources
2014
Mercury, one of the most widely diffused and hazardous organ-specific environmental contaminants, exists in a wide variety of physical and chemical states, each of which with unique characteristics of target organ specificity (Aleo et al. 2002). In nature the different forms of mercury include the metallic form, inorganic compounds, as well as alkyl ...
openaire +1 more source
Mercury, one of the most widely diffused and hazardous organ-specific environmental contaminants, exists in a wide variety of physical and chemical states, each of which with unique characteristics of target organ specificity (Aleo et al. 2002). In nature the different forms of mercury include the metallic form, inorganic compounds, as well as alkyl ...
openaire +1 more source
In vivo micronucleus test using mouse hepatocytes
Mutation Research/Environmental Mutagenesis and Related Subjects, 1989The bone-marrow micronucleus (BMM) test is highly specific for clastogenic effects but its sensitivity is determined to a great extent by the substances tested, particularly by their metabolism. Some compounds, such as unstable mutagens or those which generate short-lived metabolites, are not detected in this test because the metabolites produced in ...
I, Cliet +3 more
openaire +2 more sources
Mutation Research/Environmental Mutagenesis and Related Subjects, 1993
In vivo somatic chromosome mutation tests are usually carried out using the bone marrow micronucleus test in the mouse. This test is also considered predictive for the study of clastogenic effects in germ cells. However, it has been reported that the sensitivity of the bone marrow micronucleus test is insufficient to detect unstable compounds or short ...
I, Cliet, C, Melcion, A, Cordier
openaire +2 more sources
In vivo somatic chromosome mutation tests are usually carried out using the bone marrow micronucleus test in the mouse. This test is also considered predictive for the study of clastogenic effects in germ cells. However, it has been reported that the sensitivity of the bone marrow micronucleus test is insufficient to detect unstable compounds or short ...
I, Cliet, C, Melcion, A, Cordier
openaire +2 more sources
Genetic toxicological testing of some dyes by the micronucleus test
Mutation Research/Genetic Toxicology, 1986Three widely used dyes, acridine orange, blue VRS and fast green FCF were administered to male mice in order to study the induction of gross chromosomal anomalies using the micronucleus test. All 3 compounds were shown to be clastogenic.
R N, Misra, B, Misra
openaire +2 more sources