Results 141 to 150 of about 24,556,719 (242)

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, EarlyView.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source

Modelling the innate immune system in microphysiological systems

Lab on a Chip
Integration of an immune component moves the field closer to a physiologically relevant human-on-a-chip.
Michael J. Rupar, Hannah Hanson, Stephanie Rogers, Brianna Botlick, Steven Trimmer, James J. Hickman   +5 more
openaire   +3 more sources

Farewell to Animal Testing: Innovations on Human Intestinal Microphysiological Systems

Micromachines, 2016
The human intestine is a dynamic organ where the complex host-microbe interactions that orchestrate intestinal homeostasis occur. Major contributing factors associated with intestinal health and diseases include metabolically-active gut microbiota ...
Tae Hyun Kang, Hyun Jung Kim
doaj   +1 more source

SARS-CoV-2 infection of endothelial cells, dependent on flow-induced ACE2 expression, drives hypercytokinemia in a vascularized microphysiological system

Frontiers in Cardiovascular Medicine
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for COVID-19, has caused nearly 7 million deaths worldwide. Severe cases are marked by an aggressive inflammatory response known as hypercytokinemia, contributing to ...
Christopher J. Hatch, Sebastian Piombo, J. Fang, Johannes S. Gach, Makena L Ewald, William Van Trigt, Brian G. Coon, Jay M. Tong, D. Forthal, Christopher C W Hughes   +9 more
semanticscholar   +1 more source

Engineering Crosslinker‐Free Sericin–Gelatin Hydrogels With Tunable Rheology for 3D Printing Applications

Journal of Polymer Science, EarlyView.
Gelatin derived from porcine tissue and sericin extracted from Bombyx mori cocoons are combined to form crosslinker‐free hydrogels with tunable composition, enabling extrusion‐based 3D printing and biocompatible constructs for biomedical applications. ABSTRACT Hydrogels can be processed by 3D printing to manufacture tailor made structures, broadening ...
André S. Macedo, Alaitz Etxabide, Teresa Carranza, Ricardo Brito‐Pereira, Clarisse Ribeiro, Pedro Guerrero, Koro de la Caba, Senentxu Lanceros‐Méndez   +7 more
wiley   +1 more source

Oxidative low-density lipoprotein and shear induced calcification within a calcific aortic valve disease-on-a-chip platform

Frontiers in Cardiovascular Medicine
BackgroundEarly-stage calcific aortic valve disease (CAVD) has been characterized by the infiltration of immune cells, reorganization of the extracellular matrix, and the deposition and oxidation of low-density lipoproteins (oxLDL).
Melissa Mendoza-Seale, Mei-Hsiu Chen, Peter Huang, Gretchen J. Mahler   +3 more
doaj   +1 more source

Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system

Communications Biology
Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays.
Sophie Rigal, Belén Casas, Kajsa P. Kanebratt, Charlotte Wennberg Huldt, Lisa U. Magnusson, E. Müllers, Fredrik Karlsson, Maryam Clausen, S. Hansson, Louise Leonard, Jonathan Cairns, Rasmus Jansson Löfmark, Carina Ämmälä, Uwe Marx, Peter Gennemark, Gunnar Cedersund, Tommy B. Andersson, Liisa K. Vilén   +17 more
semanticscholar   +1 more source

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Scalable microphysiological system to model three-dimensional blood vessels

APL Bioengineering, 2019
Blood vessel models are increasingly recognized to have value in understanding disease and drug discovery. However, continued improvements are required to more accurately reflect human vessel physiology. Realistic three-dimensional (3D) in vitro cultures
Mees N. S. de Graaf, Amy Cochrane, Francijna E. van den Hil, Wesley Buijsman, Andries D. van der Meer, Albert van den Berg, Christine L. Mummery, Valeria V. Orlova   +7 more
doaj   +1 more source

Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system

npj Microgravity
The microgravity environment aboard the International Space Station (ISS) provides a unique stressor that can help understand underlying cellular and molecular drivers of pathological changes observed in astronauts with the ultimate goals of developing ...
Kevin A Lidberg, Kendan A. Jones-Isaac, Jade Yang, Jacelyn Bain, Lu Wang, James MacDonald, Theo K. Bammler, Justina Calamia, Kenneth E. Thummel, Catherine K. Yeung, Stefanie Countryman, Paul Koenig, J. Himmelfarb, Edward J. Kelly   +13 more
semanticscholar   +1 more source