Results 161 to 170 of about 24,556,719 (242)
Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen +3 more
wiley +1 more source
Perspective of using in vitro models to understand immunotherapy-induced cytokine release syndrome
Frontiers in ImmunologySince the TGN1412 clinical trial failure to predict cytokine release syndrome (CRS) during preclinical trials, alternative in vitro models have become increasingly important for identifying potential adverse outcomes in early drug development ...
Ethan Perkins +10 more
doaj +1 more source
Small Structures, Volume 7, Issue 3, March 2026.This review explores chiral nanomaterials for tissue engineering and wound healing, specifically focusing on the potential of nanocellulose. The inherent chirality of nanocelluloses and their assemblies enables the creation of biomimetic scaffolds with unique biological interactions. Chiral nematic self‐assembly of cellulose nanocrystals, in particular,
Mahboubeh Nabavinia +5 more
wiley +1 more source
Remote Cell Growth Sensing Using Self-Sustained Bio-Oscillations [PDF]
, 2018 A smart sensor system for cell culture real-time supervision is proposed, allowing for a significant reduction in human effort applied to this type of assay. The approach converts the cell culture under test into a suitable “biological” oscillator.
Daza Navarro, María Paula +9 more
core
A microphysiological system for handling graphene related materials under flow conditions.
Nanoscale HorizonsThe field of nanotechnology has developed rapidly in recent decades due to its broad applications in many industrial and biomedical fields. Notably, 2D materials such as graphene-related materials (GRMs) have been extensively explored and, as such, their
Alodia Lacueva-Aparicio +7 more
semanticscholar +1 more source
Clinical and Translational Science, Volume 19, Issue 3, March 2026.ABSTRACT Regulatory agencies such as the Food and Drug Administration (FDA), European Medicines Agency (EMA), Health Canada, and the Japanese Pharmaceutical and Medical Device Agency (PMDA) provide scientific and public health guidance with cardiac safety being paramount in drug development of new investigational products (IP).
Robert M. Lester +2 more
wiley +1 more source
Franco-British relations in Neurophysiology in Edgar Adrian's Era [PDF]
, 2006 Absen
Barbara, Jean-Gaël
core +2 more sources
Tailoring cardiac environment in microphysiological systems: an outlook on current and perspective heart-on-chip platforms [PDF]
, 2017 CRUZ MOREIRA, CATIA DANIELA +4 more
core +1 more source
PharmaceuticsMicrophysiological systems (MPSs) are promising in vitro technologies for physiologically relevant predictions of the human absorption, distribution, metabolism, and excretion (ADME) properties of drug candidates.
Patrick Carius +5 more
semanticscholar +1 more source
Advanced SciencePersistent neutrophilic inflammation can lead to tissue damage and chronic inflammation, contributing to non‐healing wounds. The resolution phase of neutrophilic inflammation is critical to preventing tissue damage.
Kehinde Adebayo Babatunde +5 more
doaj +1 more source