Results 211 to 220 of about 24,556,719 (242)

Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare.

ALTEX
The regular workshops held by the Center for Alternatives to Animal Testing (CAAT) on biology-inspired microphysiological systems (MPS) taking place every four years, have become a reliable measure to assess fundamental scientific, industrial and ...
Uwe Marx, Sonja Beken, Zaozao Chen, Eva-Maria Dehne, Ann Doherty, Lorna Ewart, Suzanne C. Fitzpatrick, L. Griffith, Zhongze Gu, Thomas Hartung, J. Hickman, Donald E. Ingber, Seiichi Ishida, Jayoung Jeong, M. Leist, L. Levin, Donna L Mendrick, G. Pallocca, Stefan Platz, Marian Raschke, Lena Smirnova, Danilo A Tagle, Martin Trapecar, B. W. van Balkom, Janny van den Eijnden-van Raaij, A. D. van der Meer, Adrian Roth   +26 more
semanticscholar   +1 more source

Microphysiological systems of the placental barrier

Advanced Drug Delivery Reviews, 2020
Methods to evaluate maternal-fetal transport across the placental barrier have generally involved clinical observations after-the-fact, ex vivo perfused placenta studies, or in vitro Transwell assays. Given the ethical and technical limitations in these approaches, and the drive to understand fetal development through the lens of transport-induced ...
Navein, Arumugasaamy, Kylie D, Rock, Che-Ying, Kuo, Tracy L, Bale, John P, Fisher   +4 more
openaire   +2 more sources

An Immune-Liver Microphysiological System Method for Evaluation and Quality Control of Hepatotoxicity Induced by Polygonum multiflorum Thunb. Extract.

Journal of Ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE Clinical applications of Polygonum multiflorum Thunb. (PMT) have occasionally reported adverse effects on liver function, linking these instances of hepatotoxicity to PMT samples. Evaluating the hepatotoxicity of PMT, given
Quanfeng Deng, Yueyang Qu, Yong Luo, Xiuli Zhang   +3 more
semanticscholar   +1 more source

Human microphysiological systems for drug development

Science, 2021
Organs-on-chips could be used to assess drug efficacy and support personalized ...
openaire   +2 more sources

Microphysiological Systems for Cancer Immunotherapy Research and Development

Advanced Biology, 2023
AbstractCancer immunotherapy focuses on the use of patients’ adaptive immune systems to combat cancer. In the past decade, FDA has approved many immunotherapy products for cancer patients who suffer from primary tumors, tumor relapse, and metastases. However, these immunotherapies still show resistance in many patients and often lead to inconsistent ...
Yansong Peng, Esak Lee
openaire   +2 more sources

Deciphering pericyte-induced temozolomide resistance in glioblastoma with a 3D microphysiological system mimicking the biomechanical properties of brain tissue.

Acta Biomaterialia
Glioblastoma (GBM) is a highly aggressive malignancy with a poor prognosis and frequent resistance to temozolomide (TMZ), the standard-of-care chemotherapy. The complex mechanisms underlying GBM chemoresistance, particularly the role of pericytes, remain
Surjendu Maity, Christopher Jewell, Can Yilgor, Satoru Kawakita, Saurabh Sharma, Alejandro Gomez, Marvin Mecwan, Natashya Falcone, M. Ermis, Mahsa Monirizad, Negar Hosseinzadeh Kouchehbaghi, Fatemeh Zehtabi, Danial Khorsandi, M. Dokmeci, Diogo Moniz-Garcia, Alfredo Quinones-Hinojosa, Ali Khademhosseini, V. Jucaud   +17 more
semanticscholar   +1 more source

Engineering pancreatic islet-loaded microfibers via pneumatically-controlled microfluidic spinning for the assembly of a microphysiological system.

Biomaterials
Microphysiological systems, including organ-on-a-chip systems, can achieve in vitro biomimicry of tissues and organs using microfluidic three-dimensional cell culture devices.
Jingyan Shi, Jianing Li, Jingyun Ma, Xiaoling Yang, Chang Xue, Yuan Zhang, Xinghua Gao   +6 more
semanticscholar   +1 more source

Biologically-Inspired Microphysiological Systems

2019
Microphysiological multi-organ devices are designed to mimic the physiological interaction of various interconnected organ models, by successfully imitating organismal functionality and response to substances. The first concepts of in vitro multi-organ systems were put forward in the late 1980s, demonstrating that such systems could provide mechanistic
Dehne, Eva Maria, Hickman, James, Shuler, Michael   +2 more
openaire   +2 more sources

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation.

Journal of Visualized Experiments
In vitro cardiac microphysiological models are highly reliable for scientific research, drug development, and medical applications. Although widely accepted by the scientific community, these systems are still limited in longevity due to the absence of ...
C. Florindi, Yongjun Jang, Kevin Shani, Paola Moretti, Chiara Bertarelli, G. Lanzani, Kevin Kit Parker, Francesco Lodola, V. Vurro   +8 more
semanticscholar   +1 more source

Aptamer Nanoconstructs Crossing Human Blood-Brain Barrier Discovered via Microphysiological System-Based SELEX Technology.

ACS Nano, 2023
Blood-brain barrier (BBB) remains one of the critical challenges in developing neurological therapeutics. Short single-stranded DNA/RNA nucleotides forming a three-dimensional structure, called aptamers, have received increasing attention as BBB shuttles
Jeong-Won Choi, Minwook Seo, Kyunghwan Kim, A‐Ru Kim, H. Lee, Hyungmin Kim, Chun Gwon Park, Seung Woo Cho, Joo H. Kang, Jinmyoung Joo, Tae-Eun Park   +10 more
semanticscholar   +1 more source