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Microphysiological Systems for Neurodegenerative Diseases in Central Nervous System [PDF]
Micromachines, 2020 Neurodegenerative diseases are among the most severe problems in aging societies. Various conventional experimental models, including 2D and animal models, have been used to investigate the pathogenesis of (and therapeutic mechanisms for) neurodegenerative diseases.
Mihyeon Bae +2 more
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Integrated biosensors for monitoring microphysiological systems
Lab on a Chip, 2022This review discusses the state-of-the-art integrated biosensors by providing specific examples, detailing their main advantages in monitoring MPSs, and describing the remaining challenges and potential future developments.
Lei Mou +10 more
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Microphysiological systems of the placental barrier
Advanced Drug Delivery Reviews, 2020Methods to evaluate maternal-fetal transport across the placental barrier have generally involved clinical observations after-the-fact, ex vivo perfused placenta studies, or in vitro Transwell assays. Given the ethical and technical limitations in these approaches, and the drive to understand fetal development through the lens of transport-induced ...
Navein, Arumugasaamy +4 more
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Microphysiological system as a promising technology for drug assay
Folia Pharmacologica Japonica, 2019 MPS (microphysiological system) is in-vitro cell-culture environment, which is precisely maintained in a micro space manufactured using MEMS (micro electro mechanical systems) technology, to derive in-vivo like functions from human cells. From the viewpoint of pharmacokinetics, it can be considered as a wet PBPK/PD simulator consisting of the micro ...
Toshiyuki Kanamori
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Microphysiological Systems for Cancer Immunotherapy Research and Development
Advanced Biology, 2023AbstractCancer immunotherapy focuses on the use of patients’ adaptive immune systems to combat cancer. In the past decade, FDA has approved many immunotherapy products for cancer patients who suffer from primary tumors, tumor relapse, and metastases. However, these immunotherapies still show resistance in many patients and often lead to inconsistent ...
Yansong Peng, Esak Lee
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Human microphysiological systems for drug development
Science, 2021Organs-on-chips could be used to assess drug efficacy and support personalized ...
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Microfluidic-based vascularized microphysiological systems
Lab on a Chip, 2018Microphysiological systems have emerged in the last decade to provide an alternative to in vivo models in basic science and pharmaceutical research.
Somin Lee +6 more
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Developing Liver Microphysiological Systems for Biomedical Applications
Advanced Healthcare Materials, 2023AbstractMicrophysiological systems (MPSs), also known as organ chips, are micro‐units that integrate cells with diverse physical and biochemical environmental cues. In the field of liver MPSs, cellular components have advanced from simple planar cell cultures to more sophisticated 3D formations such as spheroids and organoids. Additionally, progress in
Jinglin Wang +4 more
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Vascular microphysiological systems
Current Opinion in HematologyPurpose of review This review summarizes innovations in vascular microphysiological systems (MPS) and discusses the themes that have emerged from recent works. Recent findings Vascular MPS are increasing in complexity and ability to replicate tissue.
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Application of microphysiological systems in biopharmaceutical research and development
Lab on a Chip, 2020In this review, we describe some of the advances made for tissue-specific microphysiological systems and outline the advantages and challenges of applying and further developing MPS technology in preclinical biopharmaceutical research.
Norman C. Peterson +3 more
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