Results 191 to 200 of about 4,549 (220)
A microphysiological system-based potency bioassay for the functional quality assessment of mesenchymal stromal cells targeting vasculogenesis [PDF]
Biomaterials, 2022 Mesenchymal stromal cells (MSCs) continue to be proposed for use in clinical trials to treat various diseases due to their therapeutic potential to pleiotropically influence endogenous regenerative processes, such as vasculo-genesis.
Johnny Lam, James Yu, Brian J Kwee
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Microphysiological system as a promising technology for drug assay
Folia Pharmacologica Japonica, 2019 MPS (microphysiological system) is in-vitro cell-culture environment, which is precisely maintained in a micro space manufactured using MEMS (micro electro mechanical systems) technology, to derive in-vivo like functions from human cells. From the viewpoint of pharmacokinetics, it can be considered as a wet PBPK/PD simulator consisting of the micro ...
Seiichi Ishida, Toshiyuki Kanamori
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Developing Liver Microphysiological Systems for Biomedical Applications
Advanced Healthcare Materials, 2023AbstractMicrophysiological systems (MPSs), also known as organ chips, are micro‐units that integrate cells with diverse physical and biochemical environmental cues. In the field of liver MPSs, cellular components have advanced from simple planar cell cultures to more sophisticated 3D formations such as spheroids and organoids. Additionally, progress in
Jinglin Wang +4 more
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Human microphysiological systems for drug development
Science, 2021Organs-on-chips could be used to assess drug efficacy and support personalized ...
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Microfluidic-based vascularized microphysiological systems
Lab on a Chip, 2018Microphysiological systems have emerged in the last decade to provide an alternative to in vivo models in basic science and pharmaceutical research.
Somin Lee +6 more
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Microphysiological Systems for Cancer Immunotherapy Research and Development
Advanced Biology, 2023AbstractCancer immunotherapy focuses on the use of patients’ adaptive immune systems to combat cancer. In the past decade, FDA has approved many immunotherapy products for cancer patients who suffer from primary tumors, tumor relapse, and metastases. However, these immunotherapies still show resistance in many patients and often lead to inconsistent ...
Yansong Peng, Esak Lee
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Vascular microphysiological systems
Current Opinion in HematologyPurpose of review This review summarizes innovations in vascular microphysiological systems (MPS) and discusses the themes that have emerged from recent works. Recent findings Vascular MPS are increasing in complexity and ability to replicate tissue.
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Application of microphysiological systems in biopharmaceutical research and development
Lab on a Chip, 2020In this review, we describe some of the advances made for tissue-specific microphysiological systems and outline the advantages and challenges of applying and further developing MPS technology in preclinical biopharmaceutical research.
Norman C. Peterson +3 more
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Microphysiological systems inspired by leaf venation
Trends in BiotechnologyNature-inspired microfluidic networks are revolutionizing microphysiological systems, allowing for the precise emulation of human physiology. This article delves into the fabrication techniques of leaf-venation-inspired (LVI) microfluidic networks and explores their transformative applications in organ-on-a-chip and tissue engineering, showcasing their
Mao Mao +3 more
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Biologically-Inspired Microphysiological Systems
2019Microphysiological multi-organ devices are designed to mimic the physiological interaction of various interconnected organ models, by successfully imitating organismal functionality and response to substances. The first concepts of in vitro multi-organ systems were put forward in the late 1980s, demonstrating that such systems could provide mechanistic
Dehne, Eva Maria +2 more
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