Results 111 to 120 of about 24,554,140 (185)

The use of microphysiological systems to model metastatic cancer

Biofabrication
Cancer is one of the leading causes of death in the 21st century, with metastasis of cancer attributing to 90% of cancer-related deaths. Therefore, to improve patient outcomes there is a need for better preclinical models to increase the success of ...
Caitlin E. Jackson, N. Green, William R. English, F. Claeyssens   +3 more
semanticscholar   +1 more source

Stereolithographic Hydrogel Microfluidic Platform for Monitoring Cellular Respiration via Scanning Electrochemical Microscopy

Electrochemical Science Advances, Volume 6, Issue 2, April 2026.
ABSTRACT Hydrogel microfluidic devices have garnered significant interest as cell culture platforms owing to the efficient diffusion of nutrients through the hydrogel. Stereolithography, a versatile fabrication technique, has been widely adopted for the rapid prototyping of various microfluidic devices.
Taiyo Kanno, Yoshinobu Utagawa, Yusuke Kanno, Fei Li, Hiroya Abe, Hitoshi Shiku, Kosuke Ino   +6 more
wiley   +1 more source

Prioritising research on endocrine disruption in the marine environment: a global perspective

Biological Reviews, Volume 101, Issue 2, Page 848-868, April 2026.
ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto, Angelica Miglioli, Carlie A. LaLone, Lisa Baumann, Alice Baynes, Mélanie Blanc‐Legendre, Ibon Cancio, Xavier Cousin, ZhiChao Dang, Rémi Dumollard, Alex T. Ford, Christopher Green, Taisen Iguchi, Philippa Kearney, Thomas Knigge, Christophe Minier, Tiphaine Monsinjon, Marta S. Monteiro, Joachim Sturve, Haruna Watanabe, Hiroshi Yamamoto, Gerald Ankley, Deborah M. Power, Ioanna Katsiadaki   +23 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Microphysiological systems for realizing microenvironment that mimics human physiology—functional material and its standardization applied to microfluidics

Emergent Materials
Microphysiological systems (MPS), also known as Organ(s)-on-Chip (OoC), are in vitro cell culture platforms that reproduce the function of cells/tissues/organs in a microenvironment.
Y. Ito, I. Kawauchi, Y. Yanagita, Y. Sakai, M. Nishikawa, H. Arakawa, M. Kadoguchi, I. Tamai, K. Esashika, J. Takahashi, O. Ando, T. Satoh, I. Imai, S. Adachi, D. Chiba, K. Arai, K. Shiota, T. Sawaguchi, T. Yoshioka, T. Fujimoto, T. Yoshikuni, A. Mizuno, T. Aihara, T. Sakura, H. Kimura, H. Nakae   +25 more
semanticscholar   +1 more source

Paediatric developmental safety and the ICH E11A extrapolation of safety

British Journal of Clinical Pharmacology, EarlyView.
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Rebecca Racz, Sherbet Samuels, Dionna J. Green, Lynne P. Yao   +6 more
wiley   +1 more source

Multiplexed Luminal Tissue Constructs with Reconfigurable Barriers for Dynamic Modeling of Multi‐Tissue Interactions

Advanced Materials Technologies, Volume 11, Issue 5, 6 March 2026.
This study describes the fabrication of arrays of luminal tissue constructs for 3D luminal tissue modeling. An oil or media‐filled reservoir between constructs serves as a liquid barrier or bridge to regulate communication between lumens within the array for modeling multi‐tissue interactions in vitro. Abstract Cell‐lined luminal structures are crucial
Mouhita Humayun, José A. Jiménez‐Torres, Chao Li, Jose M. Ayuso, Karina Lugo‐Cintron, Joseph Ulbrich, Benjamin Myers, Sheena C. Kerr, Adeel Ahmed, David J. Beebe   +9 more
wiley   +1 more source

Estradiol and dihydrotestosterone exert sex-specific effects on human fibroblast and endothelial proliferation, bioenergetics, and vasculogenesis

Communications Biology
Sex-specific cell culture methods and microphysiological systems can enhance our understanding of how biological sex influences health and disease. Here, we investigated the effects of estradiol and dihydrotestosterone on primary human lung and ocular ...
Ashley T. Martier, Yasmin V. Maurice, K. Michael Conrad, Delia A. Carlino, Franck Mauvais-Jarvis, Mark J. Mondrinos   +5 more
doaj   +1 more source

Understanding organotropism in cancer metastasis using microphysiological systems.

Lab on a Chip
Cancer metastasis, the leading cause of cancer-related deaths, remains a complex challenge in medical science. Stephen Paget's "seed and soil theory" introduced the concept of organotropism, suggesting that metastatic success depends on specific organ ...
Jihoon Ko, Jiyoung Song, Yedam Lee, Nakwon Choi, Hongnam Kim   +4 more
semanticscholar   +1 more source

Organoids for Metabolic Disease Modeling

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic diseases (IMDs) are a diverse group of rare genetic disorders that disrupt metabolic pathways, leading to severe clinical manifestations. Disease models ranging from complex animal models to simple in vitro systems have provided insights into IMDs, but each has limitations.
Arif Ibrahim Ardisasmita, Edward Eelco Salomon Nieuwenhuis, Sabine Annemijn Fuchs   +2 more
wiley   +1 more source