Results 141 to 150 of about 21,599 (235)

Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT In autochthonous livestock breeds with small populations, such as the Rubia Galega from Galicia (Spain), mating between relatives is common and can lead to inbreeding depression. Genomic inbreeding coefficients were estimated for 4984 animals using ~63,000 SNPs to assess inbreeding depression in four key traits: age at first calving (AFC) with
N. Mejuto‐Vázquez, C. Hervás‐Rivero, R. Rodríguez‐Bermúdez, D. López‐Carbonell, M. Hermida, P. Martínez, L. Varona   +6 more
wiley   +1 more source

Roles of hypoxia-inducible microRNA-210 in hepatocellular carcinoma

, 2015
Hepatocellular carcinoma (HCC) is the fifth most prevalent human malignancy and the third leading cause of cancer deaths in the world. MicroRNAs (miRNA) are conserved, small noncoding RNA molecules that regulate gene expression of protein-coding gene posttranscriptionally.
openaire   +2 more sources

MiR‐210‐3p is upregulated in diabetic peripheral neuropathy and may be involved in the progression of the disease by targeting brain‐derived neurotrophic factor

Journal of Diabetes Investigation, EarlyView.
Elevated miR‐210‐3p expression was diagnostic for diabetic peripheral neuropathy (DPN) and served as an independent risk factor for DPN. miR‐210‐3p functioned by negatively regulating BDNF, and its inhibitor reversed hyperglycemia‐induced Schwann cell dysfunction, whereas BDNF knockdown eliminated this protective effect.
Yafei Zhao, Liu Wang, Dongcai Feng
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

A Review of the Effects of Maternal and Paternal Obesity on Neurodevelopmental Disorders and Related Neurobiology in Rodent and Human Offspring

Obesity Reviews, EarlyView.
ABSTRACT Obesity is one of the most prevalent health problems worldwide, and global obesity rates continue to rise. Consequently, rates of obesity in expecting mothers and fathers have also increased. The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that early‐life exposure to adverse environmental conditions contributes to
Hannah Chadwick, Victorio Bambini Junior, Neil Dawson, Cheryl A. Hawkes   +3 more
wiley   +1 more source

MicroRNA-210-3p Regulates Endometriotic Lesion Development by Targeting IGFBP3 in Baboons and Women with Endometriosis. [PDF]

Reprod Sci, 2023
Kai K, Joshi NR, Burns GW, Hrbek SM, Vegter EL, Ochoa-Bernal MA, Song Y, Moldovan GE, Sempere LF, Miyadahira EH, Serafini PC, Fazleabas AT.   +11 more
europepmc   +1 more source

Hypoxia-induced microRNA-210 regulation of kidney development [PDF]

, 2020
Intrauterine growth restriction is a common pregnancy complication that is thought to arise from fetal hypoxia and results in reduced nephron number. This decrease in the total amount of nephrons (which are the functional unit of the kidney) increases an
Hemker, Shelby
core  

Pangenome Analysis Reveals Structural Variations Associated With Citric Acid Accumulation in Prunus mume

Plant Biotechnology Journal, EarlyView.
ABSTRACT Pangenome can reveal a large number of variations, providing a more comprehensive view of the genetic diversity of species that a single reference genome cannot surpass. Here, we assembled the haplotype telomere‐to‐telomere genome and 10 chromosome‐level genomes, integrated with two previously reported genomes, and constructed a graph ...
Xiao Huang, Ximeng Lin, Pengyu Zhou, Wei Tan, Feng Gao, Zhaojun Ni, Ting Shi, Yang Bai, Chengdong Ma, Yufan Ma, Minglu Li, Faisal Hayat, Qixiang Zhang, Ryutaro Tao, Jianmin Wan, Zhihong Gao   +15 more
wiley   +1 more source

NF-κB Transcriptional Activity Indispensably Mediates Hypoxia-Reoxygenation Stress-Induced microRNA-210 Expression. [PDF]

Int J Mol Sci, 2023
Marwarha G, Slagsvold KH, Høydal MA.
europepmc   +1 more source