Results 1 to 10 of about 37,458 (290)

MiR-210 regulates lung adenocarcinoma by targeting HIF-1α [PDF]

Heliyon, 2023
Object: This study sought to elucidate the role of microRNA-210 (miR-210) in the occurrence and development of lung adenocarcinoma (LUAD). Methods: The levels of lncRNA miR-210HG and miR-210 in LUAD tissues and corresponding normal tissues were analyzed ...
Guolei Cao, Peiwen Fan, Ronghui Ma, Qinghe Wang, Lili He, Haiwen Niu, Qin Luo   +6 more
doaj   +4 more sources

BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression [PDF]

International Journal of Molecular Sciences, 2017
The involvement of microRNAs in the control of repressors of human g-globin gene transcription has been firmly demonstrated, as described for the miR-486-3p mediated down-regulation of BCL11A.
Jessica Gasparello, Enrica Fabbri, Nicoletta Bianchi   +2 more
exaly   +4 more sources

miR-210 loss leads to widespread phenotypic and gene expression changes in human 293T cells [PDF]

Frontiers in Genetics
IntroductionHypoxia responses are critical for myriad physiological and pathological processes, such as development, tissue repair, would healing, and tumorigenesis.
Xiaoxiao Zhang, Zhen Meng, Chengyong Yang, Chenghao Wang, Kexin Zhang, Anxin Shi, Jingjing Guo, Yong Feng, Yan Zeng   +8 more
doaj   +2 more sources

miR-210 overexpression increases pressure overload-induced cardiac fibrosis [PDF]

Non-coding RNA Research
Aortic stenosis, a common valvular heart disease, can lead to left ventricular pressure overload, triggering pro-fibrotic responses in the heart. miR-210 is a microRNA that responds to hypoxia and ischemia and plays a role in immune regulation and in ...
G. Zaccagnini, D. Baci, S. Tastsoglou, I. Cozza, A. Madè, C. Voellenkle, M. Nicoletti, C. Ruatti, M. Longo, L. Perani, C. Gaetano, A. Esposito, F. Martelli   +12 more
doaj   +2 more sources

Genetic and hypoxic alterations of the microRNA‐210‐ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension [PDF]

EMBO Molecular Medicine, 2015
Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR‐210‐ISCU1/2 axis cause Fe‐S deficiencies in vivo and promote PH.
Kevin White, Yu Lu, Sofia Annis, Andrew E Hale, B Nelson Chau, James E Dahlman, Craig Hemann, Alexander R Opotowsky, Sara O Vargas, Ivan Rosas, Mark A Perrella, Juan C Osorio, Kathleen J Haley, Brian B Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W Dean Wallace, David J Ross, Omar F Khan, Andrew Bader, Bernadette R Gochuico, Majed Matar, Kevin Polach, Nicolai M Johannessen, Haydn M Prosser, Daniel G Anderson, Robert Langer, Jay L Zweier, Laurence A Bindoff, David Systrom, Aaron B Waxman, Richard C Jin, Stephen Y Chan   +33 more
doaj   +2 more sources

HIF-1α Stabilization Increases miR-210 Eliciting First Trimester Extravillous Trophoblast Mitochondrial Dysfunction

Frontiers in Physiology, 2019
Preeclampsia is associated with first trimester placental dysfunction. miR-210, a small non-coding RNA, is increased in the preeclamptic placenta. The effects of elevated miR-210 on placental function remain unclear.
Anthony Olarerin-George, Amy G Brown, Marni J Falk   +2 more
exaly   +3 more sources

Exercise-Induced miR-210 Promotes Cardiomyocyte Proliferation and Survival and Mediates Exercise-Induced Cardiac Protection against Ischemia/Reperfusion Injury [PDF]

Research
Exercise can stimulate physiological cardiac growth and provide cardioprotection effect in ischemia/reperfusion (I/R) injury. MiR-210 is regulated in the adaptation process induced by exercise; however, its impact on exercise-induced physiological ...
Yihua Bei, Hongyun Wang, Yang Liu, Zhuhua Su, Xinpeng Li, Yujiao Zhu, Ziyi Zhang, Mingming Yin, Chen Chen, Lin Li, Meng Wei, Xiangmin Meng, Xuchun Liang, Zhenzhen Huang, Richard Yang Cao, Lei Wang, Guoping Li, Dragos Cretoiu, Junjie Xiao   +18 more
doaj   +2 more sources

Hypoxia‐induced miR‐210‐3p expression in lung adenocarcinoma potentiates tumor development by regulating CCL2 mediated monocyte infiltration [PDF]

Molecular Oncology
In most cancers, tumor hypoxia downregulates the expression of C‐C motif chemokine 2 (CCL2), and this downregulation has been implicated in monocyte infiltration and tumor progression; however, the molecular mechanism is not yet clear.
Leena Arora, Debarun Patra, Soumyajit Roy, Sidhanta Nanda, Navneet Singh, Anita K. Verma, Anuradha Chakraborti, Suman Dasgupta, Durba Pal   +8 more
doaj   +2 more sources

Elevation of Circulating miR-210 Participates in the Occurrence and Development of Type 2 Diabetes Mellitus and Its Complications [PDF]

Journal of Diabetes Research, 2022
Objective. Circulating miRNAs are acclaimed biomarkers to predict the occurrence and progression of type 2 diabetes mellitus (T2DM). This study is aimed at analyzing the correlation of circulating miR-210 level and obesity-associated T2DM and then ...
Xi Chen, Feng Tian, Zhilian Sun, Guoqing Zeng, Ping Tang   +4 more
doaj   +2 more sources

Study on the mechanism and clinical value of miR-210-3p and miR-582-5p in acute myocardial infarction by targeting MXD1 [PDF]

Journal of Cardiothoracic Surgery
Background Acute myocardial infarction (AMI) occurs rapidly and is a major cause of death in patients with coronary artery disease (CAD). To explore new biomarkers of AMI and its pathogenesis.
Shanshan Liu, Jing Han, Shufang Gao
doaj   +2 more sources