The functional and predictive roles of miR-210 in cryptorchidism
Scientific Reports, 2016 AbstractIdiopathic diseases of the reproductive system are important factors leading to male infertility. Many studies have shown that microRNAs (miRNAs) regulate the expression of multiple genes that play a significant role in spermatogenesis and development. We previously showed that microRNA-210 (miR-210) is one of the markedly upregulated microRNAs
Zhengzheng Duan, Helong Huang, Fei Sun
openaire +2 more sources
MicroRNA-210 and endoplasmic reticulum chaperones in the regulation of chemoresistance in glioblastoma [PDF]
, 2015 Glioblastoma multiforme (GBM) is the commonest primary brain tumour in adults characterized by relentless recurrence due to resistance towards the standard chemotherapeutic agent temozolomide (TMZ).
Fung, CF +8 more
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MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen [PDF]
, 2016 Additional file 2: Figure S2. Representative flow cytometric histograms of CRC cell lines 72 h post transfection with pre-miR-210 and a control miRNA, respectively.
Anne Fassl +6 more
core +4 more sources
Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation [PDF]
, 2021 Unbalanced immune responses to pathogens can be life-threatening although the underlying regulatory mechanisms remain unknown. Here, we show a hypoxia-inducible factor 1α-dependent microRNA (miR)-210 up-regulation in monocytes and macrophages upon ...
Cappellesso F. +27 more
core +8 more sources
Frontiers in Molecular Neuroscience, 2018 Vascular dementia (VD) is the most common form of dementia in elderly people. However, little is understood about the role of microRNAs (miRNAs) involved in cognitive impairment in early VD. Here, a VD model induced by chronic cerebral ischemia and fetal
Zhenxing Ren +8 more
doaj +1 more source
Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma [PDF]
, 2016 Cancer metastasis is a multistep process that involves a series of tumor-stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors.
Chan, LK +6 more
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Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways
Non-Coding RNA, 2018 Hypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditions. Previously we found that miR-210 is also involved in honeybee learning and memory, raising the questions of how neural ...
Michelle E. Watts +3 more
doaj +1 more source
Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer. [PDF]
PLoS ONE, 2015 MiR-210 is the master hypoxamir that generally exhibits oncogenic properties in most human solid tumors including bladder cancer (BC). However, it remains unknown about the clinical significance of circulating miR-210 levels in BC.
Yongmei Yang +13 more
doaj +1 more source
MicroRNA response to hypoxic stress in soft tissue sarcoma cells: MicroRNA mediated regulation of HIF3α [PDF]
, 2014 Background: Hypoxia is often encountered in solid tumors and known to contribute to aggressive tumor behavior, radiation- and chemotherapy resistance resulting in a poor prognosis for the cancer patient.
Gits, C.M.M. (Caroline) +9 more
core +1 more source
TLR3-induced placental miR-210 down-regulates the STAT6/interleukin-4 pathway. [PDF]
PLoS ONE, 2013 Several clinical studies have reported increased placental miR-210 expression in women with PE compared to normotensive women, but whether miR-210 plays a role in the etiology of PE is unknown.
Shelley E Kopriva +3 more
doaj +1 more source