Results 41 to 50 of about 367,978 (251)

Hepatocellular Carcinoma Cell-Secreted Exosomal MicroRNA-210 Promotes Angiogenesis In Vitro and In Vivo

Molecular Therapy: Nucleic Acids, 2018
We previously found that 19 microRNAs (miRNAs) significantly increased in the sera of hepatocellular carcinoma (HCC) patients. Here, we evaluated whether these miRNAs were secreted by HCC cells and contributed to tumor angiogenesis. High level of miR-210-
Xue-Jia Lin, Jian-Hong Fang, Xiao-Jing Yang, Chong Zhang, Yunfei Yuan, Limin Zheng, Shi-Mei Zhuang   +6 more
doaj   +1 more source

Expression of miR-210-3p in the aqueous humor of patients with age-related cataracts and its effect on human lens epithelial cell injury induced by hydrogen peroxide

, 2023
Purpose: The regulatory effect of microRNA on diseases has been confirmed. This study aimed to evaluate the expression of microRNA-210-3p in age-related cataracts and assess the effect of abnormal miR-210-3p expressions on H2O2-induced SAR01/04 cells ...
Famang Zheng (15311765), Xiangfeng Lou (15311768), Jianping Xu (163726), Wenlong Zhang (283123), Chen Xu (53797)   +4 more
core   +1 more source

Gingerol ameliorates neuronal damage induced by hypoxia‐reoxygenation via the miR‐210/brain‐derived neurotrophic factor axis

Kaohsiung Journal of Medical Sciences, 2022
The specific mechanism of gingerol in cerebral ischemia remains unknown. A neuroprotective function for miR‐210 in cerebral ischemia has been identified.
Yang Zhai, Bu‐Gu Liu, Xue‐Ni Mo, Min Zou, Xiao‐Ping Mei, Wei Chen, Guo‐Dong Huang, Lin Wu   +7 more
doaj   +1 more source

miR-210-3p protects against osteoarthritis through inhibiting subchondral angiogenesis by targeting the expression of TGFBR1 and ID4

Frontiers in Immunology, 2022
Excessive subchondral angiogenesis is a key pathological feature of osteoarthritis (OA), as it alters the balance of subchondral bone remodeling and causes progressive cartilage degradation.
Han Tang, Wenrun Zhu, Lu Cao, Jin Zhang, Juncheng Li, Duan Ma, Changan Guo   +6 more
doaj   +1 more source

MiR-210 diminished gemcitabine sensitivity under CoCl₂-induced pseudohypoxia.

, 2018
(A) The stably miR-210 overexpressing KKU-213 cells were incubated with gemcitabine and cultured under normoxia (N) or pseudohypoxia (H) for 72 h. (B) The stable knockdown miR-210 sponge KKU-100 cells were incubated with gemcitabine and cultured under ...
Puangrat Yongvanit (307213), Watcharin Loilome (130145), Runglawan Silakit (5465234), Suyanee Thongchot (5465240), Narong Khuntikeo (415025), Nam Hee Kim (306124), Nisana Namwat (816276), Yingpinyapat Kitirat (5465243), Anchalee Techasen (816277), Piti Ungarreevittaya (5465237), Ji Hye Yang (4279237), Jong In Yook (226843)   +11 more
core   +1 more source

MicroRNA-210-3p Targets RGMA to Enhance the Angiogenic Functions of Endothelial Progenitor Cells Under Hypoxic Conditions

Frontiers in Cellular Neuroscience, 2019
Endothelial progenitor cells (EPCs) are multipotential stem cells considered to have immense clinical value for revascularization. However, the clinical application of EPCs has been hampered by their clinical potency in ischemic anoxic environments. This
Wen-Jing Lu, Wen-Jing Lu, Huai-Bin Liang, Yong-Fang Li, Xuan-Qiang Tu, Ji-Rong He, Kai-Qi Ding, Guo-Yuan Yang, Xiao-Yu Xin, Li-Li Zeng   +9 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

MiR-210 mediates HIF-1α activity though targeting HIF-3α.

, 2018
(A) HRE (hypoxia responsive element)-reporter assay in KKU-213 cells KKU-213 cells transiently transfected with 50 nM of HIF-3α siRNA compared with control cells (mock).
Puangrat Yongvanit (307213), Watcharin Loilome (130145), Runglawan Silakit (5465234), Suyanee Thongchot (5465240), Narong Khuntikeo (415025), Nam Hee Kim (306124), Nisana Namwat (816276), Yingpinyapat Kitirat (5465243), Anchalee Techasen (816277), Piti Ungarreevittaya (5465237), Ji Hye Yang (4279237), Jong In Yook (226843)   +11 more
core   +1 more source

miR-127 protects proximal tubule cells against ischemia/reperfusion : identification of Kinesin family member 3B as miR-127 target [PDF]

, 2012
Ischemia/reperfusion (I/R) is at the basis of renal transplantation and acute kidney injury. Molecular mechanisms underlying proximal tubule response to I/R will allow the identification of new therapeutic targets for both clinical settings.
Cuppen, E., Bernhard Brüne, David Sáenz-Morales (139779), Konstantinos Stamatakis (139787), Stamatakis, K., Ramos, Edurne, Elisa Conde, Edurne Ramos (139777), Ramos, E., García Bermejo, María Laura, Blanco-Sanchez, I., Edwin Cuppen, Sáenz-Morales, David, Brune, B., Conde, E., Ignacio Blanco-Sánchez (139784), Bermejo, M.L., Luis del Peso (133134), Edwin Cuppen (9902), Stamatakis Andriani, Konstantinos, Stamatakis, Konstantinos, Peso, Luis del, del Peso, Luis, María Laura García Bermejo (139790), Saenz-Morales, D., Conde, Elisa, Konstantinos Stamatakis, María Laura García Bermejo, Edurne Ramos, Aguado-Fraile, Elia, Aguado-Fraile, E., del Peso, L., Ignacio Blanco-Sánchez, Blanco-Sánchez, Ignacio, Brüne, Bernhard, Bernhard Brüne (131193), Cuppen, Edwin, Elia Aguado-Fraile (139775), Elisa Conde (139781), Elia Aguado-Fraile, Luis del Peso, David Sáenz-Morales   +41 more
core   +1 more source