Results 21 to 30 of about 37,458 (290)
Changes and Response Predictive Values of Serum miR-210 and miR-181a in Stable Chronic Obstructive Pulmonary Disease Patients Treated with Glucocorticoid Therapy [PDF]
Zhongguo quanke yixue, 2022 Background There are rare studies assessing the efficacy of inhaled glucocorticoids (ICS) , the common therapy for chronic obstructive pulmonary disease (COPD) .
Ke QIN, Tonglin LI, Shuai GONG, Meifang JIANG
doaj +1 more source
MicroRNA-210 Suppresses Junction Proteins and Disrupts Blood-Brain Barrier Integrity in Neonatal Rat Hypoxic-Ischemic Brain Injury. [PDF]
, 2017 Cerebral edema, primarily caused by disruption of the blood-brain barrier (BBB), is one of the serious complications associated with brain injury in neonatal hypoxic-ischemic encephalopathy (HIE).
Dasgupta, Chiranjib +4 more
core +5 more sources
miR-210 Mediated Hypoxic Responses in Pancreatic Ductal Adenocarcinoma. [PDF]
ACS OmegaPancreatic ductal adenocarcinoma (PDAC) is one among the most lethal malignancies due to its aggressive behavior and resistance to conventional therapies. Hypoxia significantly contributes to cancer progression and therapeutic resistance of PDAC. microRNAs (miRNAs/miRs) have emerged as critical regulators of various biological processes.
Mortoglou M +4 more
europepmc +4 more sources
MiR‐210: an important player in the pathogenesis of preeclampsia? [PDF]
Journal of Cellular and Molecular Medicine, 2012 Hypoxia is a common feature in solid neoplastic microenvironment and a well-documented factor attributable to therapeutic failure in clinical oncology. Low oxygen availability also plays a central role in the pathogenesis of major ischaemic disorders, such as acute myocardial infarction, stroke and preeclampsia.
Liu, Changjiang +2 more
openaire +2 more sources
Hypoxia-inducible MiR-210 is an independent prognostic factor and contributes to metastasis in colorectal cancer. [PDF]
PLoS ONE, 2014 MicroRNA-210 (miR-210), the master hypoxamir, plays pleiotropic roles in certain cancers; however, its role in the development of human colorectal cancer remains unclear.
Ailin Qu +13 more
doaj +1 more source
Biomedicines, 2021 Apoptotic cell death of cardiomyocytes is a characteristic hallmark of ischemia–reperfusion (I/R) injury. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxic stress.
Gurdeep Marwarha +4 more
doaj +1 more source
Thoracic Cancer, 2021 Evidence from previous studies showed that the dysregulation of microRNA (miR) is frequently associated with tumor progression. The aberrant miR‐210 expression has been identified in a variety of tumors.
Jing Meng +5 more
doaj +1 more source
Diagnostic Value of Plasma miR-181b, miR-196a, and miR-210 Combination in Pancreatic Cancer
Gastroenterology Research and Practice, 2020 Purpose. This study was aimed at investigating the roles of plasma miR-181b, miR-196a, and miR-210 in the diagnosis of pancreatic cancer (PC). Methods. Plasma samples were isolated from 40 patients with PC and 40 healthy individuals, respectively.
Gongpan Liu +5 more
doaj +1 more source
Hypoxia induces microRNA miR‐210 in vitro and in vivo [PDF]
FEBS Letters, 2008 Shortage of oxygen is one of the prime stress conditions in tissues. In this study, we looked for microRNAs expressed during hypoxia and showed that miR‐210 expression was upregulated in response to hypoxia in vitro and in vivo. An active form of the HIF‐1α induced the expression of miR‐210, showing the involvement of the HIF‐1 signaling pathway in miR‐
Pulkkinen, Kati +4 more
openaire +2 more sources
Frontiers in Molecular Biosciences, 2021 Gemcitabine (GEM) resistance remains a challenging clinical issue to overcome in chemotherapy against pancreatic cancer. We previously demonstrated that miR-210 derived from pancreatic cancer stem cells enhanced the GEM-resistant properties of pancreatic
Fei Xu +3 more
doaj +1 more source