Results 61 to 70 of about 37,458 (290)

miR-210-3p protects against osteoarthritis through inhibiting subchondral angiogenesis by targeting the expression of TGFBR1 and ID4

Frontiers in Immunology, 2022
Excessive subchondral angiogenesis is a key pathological feature of osteoarthritis (OA), as it alters the balance of subchondral bone remodeling and causes progressive cartilage degradation.
Han Tang, Wenrun Zhu, Lu Cao, Jin Zhang, Juncheng Li, Duan Ma, Changan Guo   +6 more
doaj   +1 more source

Radiogenomics in clear cell renal cell carcinoma: correlations between advanced CT imaging (texture analysis) and microRNAs expression [PDF]

, 2019
Purpose: A relevant challenge for the improvement of clear cell renal cell carcinoma management could derive from the identification of novel molecular biomarkers that could greatly improve the diagnosis, prognosis, and treatment choice of these ...
Badia, S., Bellini, D., Carbone, A., Caruso, D., Fazi, F., Laghi, A., Marigliano, C., Miglietta, S., Palleschi, G., Pastore, A. L., Petrozza, V., Rengo, M., Tito, C.   +12 more
core   +1 more source

Overexpression of miR-210 and its significance in ischemic tissue damage [PDF]

Scientific Reports, 2017
AbstractHypoxia-induced miR-210 displays a pro-survival, cytoprotective and pro-angiogenic role in severalin vitrosystems.In vivo, we previously found that miR-210 inhibition increases ischemic damage. Here we describe the generation of a versatile transgenic mouse model allowing the evaluation of miR-210 therapeutic potential in ischemic ...
G. Zaccagnini, B. Maimone, P. Fuschi, D. Maselli, G. Spinetti, C. Gaetano, F. Martelli   +6 more
openaire   +3 more sources

MicroRNA-210-3p Targets RGMA to Enhance the Angiogenic Functions of Endothelial Progenitor Cells Under Hypoxic Conditions

Frontiers in Cellular Neuroscience, 2019
Endothelial progenitor cells (EPCs) are multipotential stem cells considered to have immense clinical value for revascularization. However, the clinical application of EPCs has been hampered by their clinical potency in ischemic anoxic environments. This
Wen-Jing Lu, Wen-Jing Lu, Huai-Bin Liang, Yong-Fang Li, Xuan-Qiang Tu, Ji-Rong He, Kai-Qi Ding, Guo-Yuan Yang, Xiao-Yu Xin, Li-Li Zeng   +9 more
doaj   +1 more source

miR‐210 promotes osteoblastic differentiation through inhibition of AcvR1b [PDF]

FEBS Letters, 2009
Although microRNAs (miRNAs) are involved in many biological processes, the mechanisms whereby miRNAs regulate osteoblastic differentiation are poorly understood. Here, we found that BMP‐4‐induced osteoblastic differentiation of bone marrow‐derived ST2 stromal cells was promoted and repressed after transfection of sense and antisense miR‐210 ...
Mizuno, Yosuke, Tokuzawa, Yoshimi, Ninomiya, Yuichi, Yagi, Ken, Yatsuka-Kanesaki, Yukiko, Suda, Tatsuo, Fukuda, Toru, Katagiri, Takenobu, Kondoh, Yasumitsu, Amemiya, Tomoyuki, Tashiro, Hideo, Okazaki, Yasushi   +11 more
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis. [PDF]

PLoS ONE, 2014
Circulating micro-RNAs have been proposed as a novel class of cardiovascular (CV) biomarkers, but whether they meet analytical requirements and provide additional information to establish risk indices have not been established.
Helge Røsjø, Mai Britt Dahl, Anja Bye, Johanna Andreassen, Marit Jørgensen, Ulrik Wisløff, Geir Christensen, Thor Edvardsen, Torbjørn Omland   +8 more
doaj   +1 more source

Malignancy Associated MicroRNA Expression Changes in Canine Mammary Cancer of Different Malignancies [PDF]

, 2014
MicroRNA has been suspected to be generally involved in carcinogenesis since their first description. A first study supported this assumption for canine mammary tumors when miRNA expression was compared to normal gland.
Deetzen, Marie-Charlotte, Gruber, Achim Dieter, Klopfleisch, Robert, Schmeck, B. T.   +3 more
core   +3 more sources

MicroRNA-210 regulates dendritic morphology and behavioural flexibility in mice [PDF]

, 2023
MicroRNAs are known to be critical regulators of neuronal plasticity. The highly-conserved, hypoxia- regulated microRNA-210 (miR-210) has been shown to be associated with long term memory in invertebrates and dysregulated in neurodevelopmental and ...
Claudianos, Charles, Lu, Jing, Nithianantharajah, Jess, Watts, Michelle, Williams, Gabrielle   +4 more
core   +1 more source

Senescent stroma promotes prostate cancer progression: The role of miR‐210 [PDF]

Molecular Oncology, 2014
We focused our interest on senescent human‐derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy‐rich compounds to support cancer cell growth.
TADDEI, MARIA LETIZIA, Cavallini L, COMITO, GIUSEPPINA, GIANNONI, ELISA, Folini M, Marini A, Gandellini P, MORANDI, ANDREA, Pintus G, Raspollini MR, Zaffaroni N, CHIARUGI, PAOLA   +11 more
openaire   +5 more sources