Results 81 to 90 of about 37,458 (290)

Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif [PDF]

, 2013
MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types.
Coarfa, Cristian, Ding, Li, Gunaratne, Preethi H., Hamilton, Mark P., Hartig, Sean M., Kandoth, Cyriac, McGuire, Sean E., McLellan, Michael D., Rajapakshe, Kimal, Reva, Boris, Wheeler, David A., Zack, Travis I.   +11 more
core   +3 more sources

miR-210 Is a Prognostic Marker in Clear Cell Renal Cell Carcinoma [PDF]

The Journal of Molecular Diagnostics, 2015
Accurate assessment of prognosis of clear cell renal cell carcinoma (ccRCC) is key in optimizing management plans to fit individual patient needs. miRNAs are short noncoding single-stranded RNAs that control the expression of target genes and may act as cancer biomarkers.
Samaan, S., Khella, H.W.Z., Girgis, A., Scorilas, A., Lianidou, E., Gabril, M., Krylov, S.N., Jewett, M., Bjarnason, G.A., El-Said, H., Yousef, G.M.   +10 more
openaire   +3 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation [PDF]

, 2010
Acute myeloid leukemia (AML) involves a block in terminal differentiation of the myeloid lineage and uncontrolled proliferation of a progenitor state. Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML ...
A Astrinidis, A Cimmino, A Pession, A Rosa, AD Basso, AW O’Sullivan, BP Lewis, C Esau, C Kanellopoulou, C le Sage, D Gaidatzis, D Liu, D O’Carroll, E Bernstein, E Gottwein, FO Martinez, GA Calin, GA Calin, GK Smyth, H Hohjoh, H Suzuki, H Tazawa, HY Chang, J Kluiver, J Severin, JF Chen, K Kitagawa, K Nie, L Fontana, M Selbach, MD Odero, N Felli, N Standart, PS Linsley, Q Liu, Q Wang, R Edgar, R Medina, R Visone, RJ Mayoral, RJ Taft, RW Georgantas 3rd, S Costinean, S Kang, S Tsuchiya, S Tsuchiya, T Beissbarth, V Martino, W Wang, Y Hayashita, Y Mizuno, YS Lee   +51 more
core   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension [PDF]

, 2017
K
Alasztics, Bálint, Biró, Orsolya, Joó, József Gábor, Molvarec, Attila, Nagy, Bálint, Rigó, János   +5 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Expressions of miR-21 and miR-210 in Breast Cancer and Their Predictive Values for Prognosis

Iranian Journal of Public Health, 2020
Background: We aimed to investigate the expressions of miR-21 and miR-210 in the breast cancer tissue and their correlation with clinicopathological features and prognosis.
Xiaofei WU
doaj   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

MicroRNA-210 Protects PC-12 Cells Against Hypoxia-Induced Injury by Targeting BNIP3

Frontiers in Cellular Neuroscience, 2017
MicroRNA (miR)-210 is the most consistently and predominantly up-regulated miR in response to hypoxia in multiple cancer cells. The roles of miR-210 in rat adrenal gland pheochromocytoma (PC-12) cells remain unknown.
Yonggang Luan, Xiaoli Zhang, Yongli Zhang, Yubin Dong   +3 more
doaj   +1 more source