Human Cyclophilins—An Emerging Class of Drug Targets
Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova +3 more
wiley +1 more source
Response by Song and Zhang to Letters Regarding Article, "MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction". [PDF]
Circulation, 2022 Song R, Zhang L.
europepmc +1 more source
Local Anesthetics in Cancer: Mechanisms and Translational Perspectives
MedComm – Oncology, Volume 5, Issue 1, March 2026.Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang +4 more
wiley +1 more source
MicroRNA-146a-5p and microRNA-210-3p Correlate with T Regulatory Cells Frequency and Predict Asthma Severity in Egyptian Pediatric Population. [PDF]
J Asthma Allergy, 2023 Eldosoky MA +12 more
europepmc +1 more source
Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery
MedComm – Oncology, Volume 5, Issue 1, March 2026.This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem +9 more
wiley +1 more source
RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang +6 more
wiley +1 more source
TET2 confers a mechanistic link of microRNA-210 and mtROS in hypoxia-suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep. [PDF]
J Physiol, 2023 Hu XQ +4 more
europepmc +1 more source
Complexity of murine cardiomyocyte miRNA biogenesis, sequence variant expression and function
, 2015 microRNAs (miRNAs) are critical to heart development and disease. Emerging research indicates that regulated precursor processing can give rise to an unexpected diversity of miRNA variants.
Cannon, Leah +8 more
core +1 more source
The Plant Genome, Volume 19, Issue 1, March 2026.Abstract To improve the identification of minor‐effect molecular markers and genes associated with quantitative traits, addressing inefficiencies in traditional molecular marker mining and the limited impact of these markers in practical breeding, we analyzed over 15,000 soybean (Glycine max) genotypes across nine maturity groups using an AI‐driven ...
Wei Zhou +6 more
wiley +1 more source
Impact of microRNA-210 on wound healing among the patients with diabetic foot ulcer. [PDF]
PLoS One, 2021 Pichu S, Vimalraj S, Viswanathan V.
europepmc +1 more source