Results 51 to 60 of about 3,995 (136)

circPDE4B downregulation triggers GEMIN5‑dependent translational stress response and autophagy to reduce MAPT pathology

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Circular RNAs (circRNAs) are emerging as key regulators of gene expression, synaptic plasticity, and neuronal function in Alzheimer's disease (AD). Here, we characterize the biological actions of circPDE4B, a highly expressed circRNA markedly reduced in AD. METHODS circPDE4B knockdown in neuronal progenitor cells was combined with
Sambhavi Puri, Sophie J. F. van der Spek, Mintao Lin, Zihan Wang, Jacob Porter, Junming Hu, Liyuan Hu, Alejandro N. Rondón‐Ortiz, Alexander Knyshov, Jenna L. Libera, Scott E. Counts, Debomoy K. Lahiri, Julia TCW, Andrew Emili, Xiaoling Zhang, Benjamin Wolozin   +15 more
wiley   +1 more source

MicroRNA-532-3p Modulates Colorectal Cancer Cell Proliferation and Invasion via Suppression of FOXM1 [PDF]

Colorectal cancer (CRC) is a heterogeneous disease and classified into various subtypes, among which transcriptional alterations result in CRC progression, metastasis, and drug resistance.
Alahari, Suresh K., Das, Ani V., Mahajan, Ketakee, Nair, S. Asha, Pothuraju, Ramesh   +4 more
core   +2 more sources

MicroRNA‐Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery

Brain and Behavior, Volume 16, Issue 5, May 2026.
Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah, Pareshkumar N. Patel, Omayma Salim Waleed, Jamuna K. V., Vandana Tripathi, L. Lakshmi, Rajashree Panigrahi, Manoj Kumar Mishra   +7 more
wiley   +1 more source

The annotated blueprint: integrated functional genomic resources for a model tetraploid wheat Triticum turgidum cv Kronos

New Phytologist, Volume 250, Issue 3, Page 1389-1410, May 2026.
Summary Triticum turgidum cv Kronos is a tetraploid wheat cultivar that underpins one of the most widely used community platforms for functional genomics. Over the past decade, researchers have generated c. 3000 exome‐capture (EC) and promoter‐capture (PC) datasets linked to mutagenized seed stocks, along with extensive transcriptomic and phenotypic ...
Kyungyong Seong, Rakesh Kumar, Daniil M. Prigozhin, China Lunde, Thales Henrique Cherubino Ribeiro, Sébastien Bélanger, Jo‐Wei Allison Hsieh, McCree Tang, Blake C. Meyers, Ksenia V. Krasileva   +9 more
wiley   +1 more source

SBP‐Box Transcription Factor JcSPL9 Regulates Both Seed Yield and Oil Content in the Biofuel Plant Jatropha curcas

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3125-3140, May 2026.
ABSTRACT Jatropha curcas is a promising feedstock for biodiesel and bio‐jet fuels production; however, its seed yield is constrained by limited inflorescences. SPL9 is a member of the SBP‐box gene family that promotes the juvenile‐to‐adult phase transition.
Mingyong Tang, Xue Bai, Yaoping Xia, Ping Huang, Zeng‐Fu Xu   +4 more
wiley   +1 more source

Nanoparticles in microdroplets: Recent advances in microfluidic generators for producing functional microbeads

Droplet, Volume 5, Issue 2, April 2026.
Functional hybrid microbeads with electrical, magnetic, and/or optical responsiveness have emerged as versatile platforms for biotechnology. This review highlights recent advances in microfluidic technologies for producing such microbeads, with a focus on incorporating functional nanoparticles in microdroplet systems.
  Bayinqiaoge, Chengchen Zhang, Shi‐Yang Tang   +2 more
wiley   +1 more source

Ultralight Conductive MXene Aerogels: From Material Design to Energy, Environment, and Electronic Applications

Small Science, Volume 6, Issue 4, April 2026.
MXene aerogels combine the intrinsic conductivity and surface chemistry of MXenes with ultralight, highly porous 3D architectures, enabling efficient charge/heat transport and multifunctional performance. By tailoring pore structure, orientation, surface functional groups, and hybrid compositions (with polymers, carbons, metals, and MOFs), MXene ...
Narasimharao Kitchamsetti, HyukSu Han, Sungwook Mhin   +2 more
wiley   +1 more source

MicroRNAs, Hypoxia and the Stem-Like State as Contributors to Cancer Aggressiveness [PDF]

, 2019
MicroRNAs (miRNAs) are small non-coding RNA molecules that play key regulatory roles in cancer acting as both oncogenes and tumor suppressors. Due to their potential roles in improving cancer prognostic, predictive, diagnostic and therapeutic approaches,
Caroline Muriithi Wanjiru, Caroline Muriithi Wanjiru, Claudia Maria Pereira, Lucy Wanjiku Macharia, Lucy Wanjiku Macharia, Marianne Wanjiru Mureithi, Valéria Pereira Ferrer, Valéria Pereira Ferrer, Vivaldo Moura-Neto, Vivaldo Moura-Neto   +9 more
core   +1 more source

Exploring the nexus: Clinical and physiological correlation between cardiovascular disease and colorectal cancer

Experimental Physiology, Volume 111, Issue 4, Page 1708-1717, 1 April 2026.
Abstract Colorectal cancer (CRC) and cardiovascular disease (CVD) are leading causes of morbidity and mortality worldwide, traditionally studied as distinct pathologies. However, emerging evidence suggests a significant physiological and molecular overlap between these conditions, indicating that they might share common pathophysiological pathways. The
Mohamad Bashir, Ali Murtada, Matti Jubouri, Wael Awad, Ian Williams, Damian M. Bailey   +5 more
wiley   +1 more source

Bibliometric analysis of mucosal immunity in IgA nephropathy from 1990 to 2022

Immunity, Inflammation and Disease
Objective The study aimed to conduct a bibliometric analysis of mucosal immunity in IgA nephropathy (IgAN) and indicate its current status, hot sopts, and direction of future studies. Methods The literature data was collected from the Web of Science Core
Xian Chen, Zhe Yan, Qing Pan, Chunxia Zhang, Yakun Chen, Xuzhi Liang, Shaomei Li, Gang Wu   +7 more
doaj   +1 more source