Results 91 to 100 of about 642,263 (291)

MiR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6

Protein & Cell, 2016
Osteosarcoma is the most common primary sarcoma of bone, and it is a leading cause of cancer death among adolescents and young adults. However, the molecular mechanism underlying osteosarcoma carcinogenesis remains poorly understood.
Kegan Zhu, Lei Liu, Junliang Zhang, Yanbo Wang, Hongwei Liang, Gentao Fan, Zhenhuan Jiang, Chen-Yu Zhang, Xi Chen, Guangxin Zhou   +9 more
doaj   +1 more source

MicroRNAs in Cancer [PDF]

Annual Review of Pathology: Mechanisms of Disease, 2014
MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation, apoptosis, and migration.
Gianpiero Di Leva, Michela Garofalo, Carlo M. Croce   +2 more
openaire   +3 more sources

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs [PDF]

, 2016
Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers.
Alfano, Vincenzo, Besharat, ZEIN MERSINI, Carai, Andrea, Catanzaro, Giuseppina, Ferretti, Elisabetta, Garg, Neha, Locatelli, Franco, Mastronuzzi, Angela, Miele, Evelina, Pieroni, Luisa, Po, Agnese, Ronci, Maurizio, Screpanti, Isabella, Urbani, Andrea   +13 more
core   +4 more sources

MicroRNA-24 regulates vascularity after myocardial infarction [PDF]

, 2011
BACKGROUND: Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying ...
Bauersachs, J., Brand, T., Engelhardt, S., Ertl, G., Fiedler, J., Galuppo, P., Gupta, S. K., Hartmann, D., Heineke, J., Jazbutyte, V., Kirchmaier, B. C., Kneitz, S., Lorenzen, J., Loyer, X., Martin, U., Pena, J., Schulte-Merker, S., Sohn-Lee, C., Soutschek, J., Thum, T., Tuschl, T.   +20 more
core   +3 more sources

Protecting and rejuvenating ageing skin by regulating endogenous hyaluronan metabolism using adipose-derived stem cell-secreted siRNAs

Frontiers in Medicine
BackgroundLoss of moisture is the primary cause of skin ageing and dysfunction. The skin’s hydration largely depends on hyaluronan (HA) and its ability to retain water.
Benben Sun, Yanqiu He, Lingzhu Zhang, Siyu Liu, Menghan Chen, Jinmeng Pan, Jingwen Fang, Ye Wang, Haiyue Jiang, Xia Liu, Chen-Yu Zhang, Chen-Yu Zhang, Chen-Yu Zhang, Jing Li, Jing Li   +14 more
doaj   +1 more source

MicroRNA-125b-5p mimic inhibits acute liver failure

Nature Communications, 2016
miR125b-5p has been associated with acute liver failure. Here the authors show that this miRNA targets Keap1 and activates Nrf2 to inhibit liver cell death after APAP or FAS toxicity, plus they show that a miR125b-5p mimic can inhibit ALF in mice.
Dakai Yang, Qinggong Yuan, Asha Balakrishnan, Heike Bantel, Jan-Henning Klusmann, Michael P. Manns, Michael Ott, Tobias Cantz, Amar Deep Sharma   +8 more
doaj   +1 more source

Antiviral microRNA expression signatures are altered in subacute sclerosing panencephalitis

Neurological Sciences and Neurophysiology, 2021
Background: Subacute sclerosing panencephalitis (SSPE) is a chronic, progressive disease caused by a persistent infection of the measles virus. Despite extensive efforts, the exact neurodegeneration mechanism in SSPE remains unknown.
Kemal Ugur Tufekci, Jens Allmer, Kürşat Bora Çarman, Erhan Bayram, Yasemin Topçu, Semra Hız, Şermin Genç, Uluç Yiş   +7 more
doaj   +1 more source

miRNAs link metabolic reprogramming to oncogenesis [PDF]

, 2013
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M, Iliopoulos, D, Polytarchou, C   +2 more
core   +1 more source

miRWalk: An online resource for prediction of microRNA binding sites

PLoS ONE, 2018
miRWalk is an open-source platform providing an intuitive interface that generates predicted and validated miRNA-binding sites of known genes of human, mouse, rat, dog and cow.
C. Sticht, C. de la Torre, Alisha Parveen, N. Gretz   +3 more
semanticscholar   +1 more source

Regulatory Mechanism of MicroRNA Expression in Cancer

International Journal of Molecular Sciences, 2020
Altered gene expression is the primary molecular mechanism responsible for the pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are virtually involved at the post-transcriptional level and bind to 3′ UTR of their target ...
Zainab Ali Syeda, Siu Semar Saratu' Langden, Choijamts Munkhzul, Mihye Lee, S. Song   +4 more
semanticscholar   +1 more source