Results 91 to 100 of about 282,025 (323)

Depth Normalization of Small RNA Sequencing: Using Data and Biology to Select a Suitable Method [PDF]

arXiv, 2022
Deep sequencing has become one of the most popular tools for transcriptome profiling in biomedical studies. While an abundance of computational methods exists for "normalizing" sequencing data to remove unwanted between-sample variations due to experimental handling, there is no consensus on which normalization is the most suitable for a given data set.
arxiv  

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

MicroRNA-17, MicroRNA-19b, MicroRNA-146a, MicroRNA-302d Expressions in Hepatoblastoma and Clinical Importance

Journal of Pediatric Hematology/Oncology, 2019
Hepatoblastoma (HB) is the most common liver malignancy in children. The prognosis changes according to the histologic subtypes of HB. In the present study, we aimed to characterize the expression level of selected microRNAs (miRNAs) in HB as well as in histologic subtypes, and to consider the association with the prognosis.
Aktas, Safiye, Ecevit, Cigdem O., Yildirim, Hulya Tosun, Demirag, Bengu, Erbay, Ayse, Karaca, Irfan, Celik, Ahmet, Demir, Ayse Banu, Ercetin, Ayse Pinar, Olgun, Nur   +9 more
openaire   +5 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

The evolution of microRNA-regulation in duplicated genes facilitates expression divergence [PDF]

arXiv, 2008
Background: The evolution of microRNA regulation in metazoans is a mysterious process: MicroRNA sequences are highly conserved among distal organisms, but on the other hand, there is no evident conservation of their targets. Results: We study this extensive rewiring of the microRNA regulatory network by analyzing the evolutionary trajectories of ...
arxiv  

Recent Advances in Enzyme‐based Biofuel Cells Using Glucose Fuel: Achieving High Power Output and Enhanced Operational Stability

Advanced Functional Materials, EarlyView.
Effective electron transfer and stable enzyme immobilization, both between enzymes and host electrodes as well as between adjacent enzymes, are crucial for optimizing the biofuel cell (BFC) performance. Recently, efforts have focused on integrating these strategies with porous host electrodes.
Junha Pak, Woojae Chang, Cheong Hoon Kwon, Jinhan Cho   +3 more
wiley   +1 more source

Birth defects associated with paternal firefighting in the National Birth Defects Prevention Study

American Journal of Industrial Medicine, Volume 66, Issue 1, Page 30-40, January 2023., 2023
Abstract Background Few studies have evaluated birth defects among children of firefighters. We investigated associations between birth defects and paternal work as a firefighter compared to work in non‐firefighting and police officer occupations. Methods We analyzed 1997–2011 data from the multi‐site case‐control National Birth Defects Prevention ...
Miriam R. Siegel, Carissa M. Rocheleau, Brittany S. Hollerbach, Amel Omari, Sara A. Jahnke, Lynn M. Almli, Andrew F. Olshan, National Birth Defects Prevention Study   +7 more
wiley   +1 more source

LncRNA CASC2 Alleviates the Progression of Diabetic Nephropathy by Regulating the miR-144/SOCS2 Signalling Axis

Kidney & Blood Pressure Research, 2020
Background: Diabetic nephropathy constitutes a large proportion of end-stage kidney failure in diabetic patients. However, the underlying molecular mechanisms remain unclear.
Xiao-Qiang Min, Yan Xie
doaj   +1 more source

Gene autoregulation via intronic microRNAs and its functions [PDF]

arXiv, 2012
Background: MicroRNAs, post-transcriptional repressors of gene expression, play a pivotal role in gene regulatory networks. They are involved in core cellular processes and their dysregulation is associated to a broad range of human diseases. This paper focus on a minimal microRNA-mediated regulatory circuit, in which a protein-coding gene (host gene ...
arxiv  

Ovarian Function Restoration with Biomimetic Scaffold Incorporating Angiogenic Molecules and Antioxidant in Chemotherapy‐Induced Perimenopausal Model

Advanced Healthcare Materials, EarlyView.
This study developed a biomimetic scaffold incorporating PDRN and melatonin to restore ovarian function in chemotherapy‐induced premature ovarian insufficiency, enhancing cell survival, folliculogenesis, and hormone normalization, while improving fertility rates and offspring in a mouse model, offering a promising strategy for ovarian function ...
Da‐Seul Kim, Dong Seok Jeong, So‐Yeon Park, Ji‐Won Jung, Jeoung Eun Lee, Jun‐Kyu Lee, Seung‐Woon Baek, Dong Ryul Lee, Dong Keun Han   +8 more
wiley   +1 more source