Results 161 to 170 of about 285,352 (309)

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

Advanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma, Lingyun He, Xinru Wang, Yuanyuan Wei, Chengcheng Li, Jiaqi Yan, Weijian Sun, Xian Shen, Hongbo Zhang   +8 more
wiley   +1 more source

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi‐Omics Data

Advanced Science, EarlyView.
MAPA transforms complex multi‐omics data into biologically coherent functional modules by integrating pathway information with molecular interaction networks. Retrieval‐augmented large language models then generate structured, literature‐informed interpretations.
Yifei Ge, Feifan Zhang, Yijiang Liu, Chao Jiang, Peng Gao, Nguan Soon Tan, Sai Zhang, Yuchen Shen, Qianyi Zhou, Xin Zhou, Xiao Wang, Fangqing Zhao, Chuchu Wang, Xiaotao Shen   +13 more
wiley   +1 more source

Genetic variants in microRNA genes and microRNA binding sites associated with diabetic retinopathy

, 2018
Purpose : Genetic variants in microRNA genes and microRNA binding sites have not been studied systematically in association with diabetic retinopathy (DR).
Liu, Ebony, Burdon, Kathryn P, Daniell, Mark, Abhary, Sotoodeh, Gillies, Mark C, McComish, Bennet, Kaidonis, Georgia, Craig, Jamie E, Petrovsky, Nikolai, Gleadle, Jonathan   +9 more
core  

RIBOTAC-mediated degradation of hsa-microRNA-301a-3p suppresses TNBC bone metastasis. [PDF]

Sci Adv
Zhou W, Jin J, Liang XH, Yan Y, Xiong Q, Lu D, Chen H, Wu Y, Zhang WD, Luan X.   +9 more
europepmc   +1 more source

Heavy Metal Contamination: Impacts From Plants to the Food Chain and Eco‐Friendly Amelioration Strategies

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Heavy metal pollution reduces soil health and threatens food safety by entering plants; however, the use of nanoparticles, biofertilizers, and organic fertilizers such as biochar offers a promising strategy for improvement and sustainable agriculture. ABSTRACT Heavy metal (HM) pollution, resulting from human activities such as mining and the excessive ...
Sina Siavash Moghaddam, Latifeh Pourakbar, Sevda Alizadeh, Zahra Alizadeh, Jelena Popović‐Djordjević   +4 more
wiley   +1 more source

LncRNA-XIST Competitively Binds to MicroRNA-532-5p to Regulate PTEN Expression, Exacerbating Cerebral Ischemia-Reperfusion Injury. [PDF]

Adv Biol (Weinh)
Lu X, Chen L, Qian L, Zhang X, Wang Y, Yu B.   +5 more
europepmc   +1 more source

Arabidopsis MicroRNAs [PDF]

Plant Physiology, 2008
openaire   +2 more sources

MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li, Yang Liu, Hua Chen, Jialin Li, Xinchun Li, Yanmin Chen   +5 more
wiley   +1 more source

Nitro Reduction‐Based RNA Control and Ultrafast Release

Angewandte Chemie, EarlyView.
A chemical RNA caging–uncaging strategy based on nitro reduction is described. Nitroaryl groups introduced via acylation temporarily block the functions of diverse RNAs in vitro and in living cells. Treatment with a diboronic acid–bipyridine mixture rapidly reduces the nitro groups, releasing RNAs and restoring their activity.
Yiran Zhao, Senfeng Zhang, Junsong Guo, Tuan‐Khoa Kha, Song Chen, Chunyi Hu, Ru‐Yi Zhu   +6 more
wiley   +2 more sources

The Promise and Pursuit of MicroRNAs for Cancer Treatment. [PDF]

Biomolecules
Boothe C, Rossi A, Kalil J, Latimer JJ.
europepmc   +1 more source