Results 81 to 90 of about 471,948 (340)

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN

Molecular Cancer, 2019
Background Circular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs formed by a covalently closed loop, and increasing evidence has revealed that circRNAs play crucial functions in regulating gene expression.
Qun Lu, Tianyao Liu, Huijin Feng, Rong Yang, Xiaozhi Zhao, Wei Chen, Bo Jiang, Haixiang Qin, Xu Guo, Minghui Liu, Limin Li, Hongqian Guo   +11 more
doaj   +1 more source

Role and mechanism of microRNAs in oral lichen planus

口腔疾病防治, 2020
Oral lichen planus (OLP) is a chronic inflammatory disease of the mucosa, some of which will develop into oral squamous cell carcinoma (OSCC). However, the pathogenesis of OLP remains unknown, but autoimmunity has been suggested as a potential cause ...
YANG Yijie, GE Shuyun
doaj   +1 more source

PseudoFuN: Deriving functional potentials of pseudogenes from integrative relationships with genes and microRNAs across 32 cancers [PDF]

, 2019
BACKGROUND: Long thought "relics" of evolution, not until recently have pseudogenes been of medical interest regarding regulation in cancer. Often, these regulatory roles are a direct by-product of their close sequence homology to protein-coding genes.
Campbell, Moray J., Dan Li, Shuyu, Franz, Eric, Huang, Kun, Huang, Zhi, Johnson, Travis S., Li, Sihong, Zhang, Yan   +7 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

MicroRNA-125b-5p mimic inhibits acute liver failure

Nature Communications, 2016
miR125b-5p has been associated with acute liver failure. Here the authors show that this miRNA targets Keap1 and activates Nrf2 to inhibit liver cell death after APAP or FAS toxicity, plus they show that a miR125b-5p mimic can inhibit ALF in mice.
Dakai Yang, Qinggong Yuan, Asha Balakrishnan, Heike Bantel, Jan-Henning Klusmann, Michael P. Manns, Michael Ott, Tobias Cantz, Amar Deep Sharma   +8 more
doaj   +1 more source

MiR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6

Protein & Cell, 2016
Osteosarcoma is the most common primary sarcoma of bone, and it is a leading cause of cancer death among adolescents and young adults. However, the molecular mechanism underlying osteosarcoma carcinogenesis remains poorly understood.
Kegan Zhu, Lei Liu, Junliang Zhang, Yanbo Wang, Hongwei Liang, Gentao Fan, Zhenhuan Jiang, Chen-Yu Zhang, Xi Chen, Guangxin Zhou   +9 more
doaj   +1 more source

LncRNA NEAT1 modulates sorafenib resistance in hepatocellular carcinoma through regulating the miR-149-5p/AKT1 axis

The Saudi Journal of Gastroenterology, 2020
Background/Aims: The purpose of this study is to explore the expression characteristics of lncRNA NEAT1 in hepatocellular carcinoma (HCC) and the molecular mechanism of its regulation on sorafenib resistance.
Yuexiang Niu, Gongen Tang, Xiuli Wu, Chaoyu Wu   +3 more
doaj   +1 more source

The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment [PDF]

, 2014
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third leading cause of cancer deaths. microRNAs (miRNAs) are evolutionary conserved small non-coding RNA that negatively regulate gene expression and protein translation ...
Bianconi Maristella, Cascinu Stefano, D'Anzeo Marco, Del Prete Michela, Faloppi Luca, Giampieri Riccardo, SCARTOZZI, MARIO, Silvestris Nicola   +7 more
core   +1 more source