Results 1 to 10 of about 384,313 (313)
Simple Mathematical Model Of Pathologic Microsatellite Expansions: When Self-Reparation Does Not Work [PDF]
J. Theor. Biol., 2006, v. 242, 401--408, 2007 We propose a simple model of pathologic microsatellite expansion, and describe an inherent self-repairing mechanism working against expansion. We prove that if the probabilities of elementary expansions and contractions are equal, microsatellite expansions are always self-repairing.
Amos +48 more
arxiv +3 more sources
Applied Sciences, 2023 For the purpose of fulfilling the low sidelobe level (SLL) requirements for spaceborne phased array antenna pattern synthesis, this paper proposes a new improved whale optimization algorithm (IWOA).
Hongming Hu +5 more
doaj +1 more source
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2023 The quality of optical remote sensing images is largely affected by clouds and haze. In addition, the mosaicking image of multiple remote sensing images, due to objective factors such as acquiring time or climate conditions, will lead to large spectral ...
Zhipan Wang +4 more
doaj +1 more source
SiamHRnet-OCR: A Novel Deforestation Detection Model with High-Resolution Imagery and Deep Learning
Remote Sensing, 2023 Forests play a critical role in global carbon cycling, and continuous forest destruction together with other factors has accelerated global warming.
Zhipan Wang +5 more
doaj +1 more source
A Combined Residual Detection Method of Reaction Wheel for Fault Detection
Shanghai Jiaotong Daxue xuebao, 2021 A fault detection method of combined residual is proposed to effectively master the health state of the reaction wheels of in-orbit satellite according to the telemetry data. Based on the characteristics of in-orbit telemetry data, in the proposed method,
HE Xiawei, CAI Yunze, YAN Lingling
doaj +1 more source
Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer.
New England Journal of Medicine, 2020 BACKGROUND Programmed death 1 (PD-1) blockade has clinical benefit in microsatellite-instability-high (MSI-H) or mismatch-repair-deficient (dMMR) tumors after previous therapy.
T. André +20 more
semanticscholar +1 more source
Microsatellite Instability in Yeast: Dependence on the Length of the Microsatellite [PDF]
Genetics, 1997 One of the most common microsatellites in eukaryotes consists of tandem arrays [usually 15-50 base pairs (bp) in length] of the dinucleotide GT. We examined the rates of instability for poly GT tracts of 15, 33, 51, 99 and 105 bp in wild-type and mismatch repair-deficient strains of Saccharomyces cerevisiae. Rates of instability increased more than two
Monika Wierdl +2 more
openaire +2 more sources
Frontiers in Oncology, 2021 Colorectal cancer (CRC), a common malignant disease, has the second highest mortality rate among all cancer types. Due to the diversity and heterogeneity of CRC, few effective treatment strategies have been developed in recent years, except for surgical ...
Rui He +5 more
doaj +1 more source
Microsatellite instability: a review of what the oncologist should know
Cancer Cell International, 2020 The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR) tumors recently have been reported that can benefit from immunotherapy, and MSI can be used as a genetic instability of a tumor detection index.
Kai Li +4 more
semanticscholar +1 more source
The death of a microsatellite: a phylogenetic perspective on microsatellite interruptions [PDF]
Molecular Biology and Evolution, 1999 Microsatellite mutations can be studied by direct observation in pedigrees (Weber and Wong 1993; Crawford and Cuthbertson 1996; Primmer et al. 1996), by sequencing alleles (Blanquer-Maumont and Crouau-Roy 1995; Estoup et al. 1995; Garza and Freimer 1996; Metzgar et al. 1998; Taylor, Sanny, and Breden 1999), and by mapping allele sizes or sequences onto
J. M. H. Durkin +2 more
openaire +2 more sources