Diagnosis and management of gestational trophoblastic disease: 2025 update
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Gestational trophoblastic disease (GTD) arises from abnormal placenta and comprises a spectrum of premalignant to malignant disorders. Changes in the epidemiology of GTD have been noted in various countries. In addition to histology, molecular genetic studies can help in the diagnostic pathway.
Hextan Y. S. Ngan +7 more
wiley +1 more source
MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas [PDF]
, 1998 Manel Esteller +4 more
openalex +1 more source
TMB‐High, MSI‐High Castration‐Resistant Prostate Cancer Treated With Pembrolizumab
IJU Case Reports, EarlyView.ABSTRACT Introduction The use of pembrolizumab in patients with microsatellite instability‐high (MSI‐high) and tumor mutation burden‐high (TMB‐high) prostate cancer in Japan is not widely reported. Here, we report the case of a patient with MSI‐high and TMB‐high prostate cancer who responded well to pembrolizumab after multiple systemic treatments ...
Satoshi Muraoka +8 more
wiley +1 more source
Microsatellite allele frequencies in humans and chimpanzees, with implications for constraints on allele size. [PDF]
, 1995 John Carlos Garza +2 more
openalex +1 more source
Performance Evaluation of a New HRD Assay (HRDsig) in Ovarian Carcinomas in Australia
Journal of Clinical Laboratory Analysis, EarlyView.In this study we have evaluated the performance of a new HRD assay (HRDsig) against two accredited HRD assays, as well as against commercial controls and inter‐laboratory comparison samples. HRDsig has demonstrated a high concordance rate for determining HRD status in ovarian carcinomas.
Pranav Dorwal +11 more
wiley +1 more source
JPGN Reports, EarlyView.Abstract Constitutional mismatch repair deficiency (CMMRD) is a rare hereditary cancer syndrome resulting from biallelic mutations in DNA mismatch repair (MMR) genes that lead to early‐onset cancers in children, including lymphoma and colorectal cancer (CRC).
Chloe J. Cohan +3 more
wiley +1 more source
Genetic diversity of Asian water buffalo (Bubalus bubalis): microsatellite variation and a comparison with protein‐coding loci [PDF]
, 1997 J. S. F. Barker +5 more
openalex +1 more source
A rare case of colonic adenocarcinoma in a pediatric patient
JPGN Reports, EarlyView.Abstract Lynch syndrome (LS) is an autosomal dominant condition caused by a loss of function in the deoxyribonucleic acid mismatch repair system. This case report presents a 17‐year‐old male with abdominal pain, weight loss, and anemia who was diagnosed with LS‐associated adenocarcinoma of the colon in the setting of a mutS homolog 6 genetic mutation ...
Christine Kaba +4 more
wiley +1 more source
Microsatellite variability and genetic distances. [PDF]
, 1995 Lev A. Zhivotovsky, M.W. Feldman
openalex +1 more source
Less Is More: Risk Factors and Survival Outcomes of Overtreatment for Early‐Stage Colorectal Cancer
Journal of Surgical Oncology, EarlyView.ABSTRACT Background and Objectives After cT1‐2N0M0 colorectal cancer (CRC) definitive resection (colectomy/proctectomy) without pathologic upstaging, only observation is recommended given the lack of benefit from adjuvant treatment, which would constitute overtreatment. This study aims to determine risk factors and overall survival (OS) associated with
Daniel R. S. Habib +5 more
wiley +1 more source