Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer.
New England Journal of Medicine, 2020 BACKGROUND Programmed death 1 (PD-1) blockade has clinical benefit in microsatellite-instability-high (MSI-H) or mismatch-repair-deficient (dMMR) tumors after previous therapy.
T. André +20 more
semanticscholar +1 more source
Microsatellite instability: a review of what the oncologist should know
Cancer Cell International, 2020 The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR) tumors recently have been reported that can benefit from immunotherapy, and MSI can be used as a genetic instability of a tumor detection index.
Kai Li +4 more
semanticscholar +1 more source
MISA-web: a web server for microsatellite prediction
Bioinform., 2017 Motivation: Microsatellites are a widely‐used marker system in plant genetics and forensics. The development of reliable microsatellite markers from resequencing data is challenging.
Sebastian Beier +4 more
semanticscholar +1 more source
Development and characterization of tri- and tetra-nucleotide polymorphic microsatellite markers for skipjack tuna (Katsuwonus pelamis) [PDF]
, 2012 Skipjack tuna (katsuwonus pelamis) (SJT) is the largest tuna fishery in all the major oceans around the world, and the largest marine fishery in Sri Lanka. Knowledge of genetic population structure and effective population size of SJT in the Indian Ocean
Chand, Vincent +2 more
core +2 more sources
Microsatellite null alleles and estimation of population differentiation.
Molecular biology and evolution, 2007 Microsatellite null alleles are commonly encountered in population genetics studies, yet little is known about their impact on the estimation of population differentiation.
M. Chapuis, A. Estoup
semanticscholar +1 more source
Varying genetic imprints of road networks and human density in North American mammal populations
Evolutionary Applications, 2021 Road networks and human density are major factors contributing to habitat fragmentation and loss, isolation of wildlife populations, and reduced genetic diversity.
Andrew K. Habrich +2 more
doaj +1 more source
Measuring microsatellite conservation in mammalian evolution with a phylogenetic birth-death model. [PDF]
, 2012 Microsatellites make up ∼3% of the human genome, and there is increasing evidence that some microsatellites can have important functions and can be conserved by selection.
Buschiazzo, Emmanuel +4 more
core +1 more source
Micro-Checker: Software for identifying and correcting genotyping errors in microsatellite data
, 2004 DNA degradation, low DNA concentrations and primer-site mutations may result in the incorrect assignment of microsatellite genotypes, potentially biasing population genetic analyses.
C. Oosterhout +3 more
semanticscholar +1 more source
Journal of the National Cancer Institute, 2004 Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, neoplastic lesions, and microsatellite instability (MSI).
A. Umar +22 more
semanticscholar +1 more source
Population structure of chum salmon and selection on the markers collected for stock identification
Ecology and Evolution, 2021 Genetic stock identification (GSI) is a major management tool of Pacific salmon (Oncorhynchus Spp.) that has provided rich genetic baseline data of allozymes, microsatellites, and single‐nucleotide polymorphisms (SNPs) across the Pacific Rim.
Shuichi Kitada, Hirohisa Kishino
doaj +1 more source