TMB‐High, MSI‐High Castration‐Resistant Prostate Cancer Treated With Pembrolizumab
IJU Case Reports, EarlyView.ABSTRACT Introduction The use of pembrolizumab in patients with microsatellite instability‐high (MSI‐high) and tumor mutation burden‐high (TMB‐high) prostate cancer in Japan is not widely reported. Here, we report the case of a patient with MSI‐high and TMB‐high prostate cancer who responded well to pembrolizumab after multiple systemic treatments ...
Satoshi Muraoka +8 more
wiley +1 more source
New trend in molecular diagnostics: Insights from the tumor microenvironment
Interdisciplinary Medicine, EarlyView.The graphical abstract outline the key elements in TME‐based molecular diagnostics, including biomarker exploration, diagnostic methods, and diagnostic models. Source: Created with BioRender.com. Abstract Molecular diagnosis has revolutionized cancer precision medicine.
Baiyuan Fan +3 more
wiley +1 more source
Performance Evaluation of a New HRD Assay (HRDsig) in Ovarian Carcinomas in Australia
Journal of Clinical Laboratory Analysis, EarlyView.In this study we have evaluated the performance of a new HRD assay (HRDsig) against two accredited HRD assays, as well as against commercial controls and inter‐laboratory comparison samples. HRDsig has demonstrated a high concordance rate for determining HRD status in ovarian carcinomas.
Pranav Dorwal +11 more
wiley +1 more source
A rare case of colonic adenocarcinoma in a pediatric patient
JPGN Reports, EarlyView.Abstract Lynch syndrome (LS) is an autosomal dominant condition caused by a loss of function in the deoxyribonucleic acid mismatch repair system. This case report presents a 17‐year‐old male with abdominal pain, weight loss, and anemia who was diagnosed with LS‐associated adenocarcinoma of the colon in the setting of a mutS homolog 6 genetic mutation ...
Christine Kaba +4 more
wiley +1 more source
Less Is More: Risk Factors and Survival Outcomes of Overtreatment for Early‐Stage Colorectal Cancer
Journal of Surgical Oncology, EarlyView.ABSTRACT Background and Objectives After cT1‐2N0M0 colorectal cancer (CRC) definitive resection (colectomy/proctectomy) without pathologic upstaging, only observation is recommended given the lack of benefit from adjuvant treatment, which would constitute overtreatment. This study aims to determine risk factors and overall survival (OS) associated with
Daniel R. S. Habib +5 more
wiley +1 more source
Homoplasy for size at microsatellite loci in humans and chimpanzees. [PDF]
, 1996 John Carlos Garza, Nelson B. Freimer
openalex +1 more source
A combined DNA-microsatellite and isozyme analysis of the population structure of the harbour porpoise in Danish waters and West Greenland [PDF]
, 1997 Liselotte Wesley Andersen +5 more
openalex +2 more sources
Microsatellite Instability and BAT-26 Marker Expression in a Mexican Prostate Cancer Population with Different Gleason Scores. [PDF]
DiseasesFlores-Islas AK +9 more
europepmc +1 more source
Microsatellite instability—a useful diagnostic tool to select patients at high risk for hereditary non-polyposis colorectal cancer: a study in different groups of patients with colorectal cancer [PDF]
, 1999 C. Lamberti +10 more
openalex +1 more source
Limnology and Oceanography, EarlyView.Abstract Spatial environmental heterogeneity is an important driver of aquatic biodiversity. Ecological and evolutionary theory often consider spatial heterogeneity as being driven by exogenous factors, yet heterogeneity can also be generated and modified by organisms.
Romana Limberger +4 more
wiley +1 more source