Results 221 to 230 of about 164,070 (265)

Cancer and forensic microsatellites

Forensic Science, Medicine, and Pathology, 2008
Although not directly related, circumstances do occur in forensic investigations whereby cancer studies and forensic science cross paths. This review takes a look at the circumstances under which this may occur, and investigates some potential problems that can arise when tumor tissue is submitted for DNA profile analysis.
Karen, Page, Eleanor A M, Graham
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Microsatellites: consensus and controversy

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000
Microsatellite DNA loci have recently been adopted for many biological applications. Comparative studies across a wide range of species has revealed many details of their mutational properties and evolutionary life cycles. Experience shows that a full understanding of these processes is essential to ensure the effective use of microsatellites as ...
G K, Chambers, E S, MacAvoy
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Microsatellites

1998
Abstract Microsatellites are highly polymorphic DNA markers with discrete loci and co dominant alleles. They have a wide range of applications which previously were difficult to address experimentally. Microsatellites are almost uniformly distributed over the entire genome, which is what makes them so useful for genome mapping projects ...
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Microsatellite Instability Testing

2003
Microsatellites are tandem repeats of simple sequences that occur abundantly and are randomly interspersed throughout the human genome. They typically consist of 10-50 copies of 1-6 bp motifs, and are characterized by a high degree of polymorphism. Despite the variability observed among individuals, microsatellite are replicated faithfully at each cell
Y R, Parc, K C, Halling
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Characterization of canine microsatellites

1993
Canine DNA was cloned in M13 and screened for the presence of (dC-dA)n.(dG-dT)n repeats. Oligonucleotide primers were synthesised to the microsatellite flanking sequences and used in the polymerase chain reaction to amplify those loci from genomic DNA. The polymorphism of each microsatellite was estimated in a set of unrelated dogs.
N G, Holmes, S J, Humphreys, M M, Binns, R, Curtis, A, Holliman, A M, Scott   +5 more
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Microsatellite instability: an update

Archives of Toxicology, 2015
Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers. MSI is characterized by length alterations within simple repeated sequences that are called microsatellites.
Hiroyuki, Yamamoto, Kohzoh, Imai
openaire   +2 more sources

The birth of microsatellites

Nature, 1996
W, Messier, S H, Li, C B, Stewart
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Setting microsatellites free

Nature Medicine, 1996
Altered microsatellite DNA in the blood of cancer patients may provide a novel method for tumor detection (pages 1033-1037).
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Informativeness of Microsatellite Markers

2013
Simple sequence repeats (SSR) are extensively used as genetic markers for studies of diversity, genetic mapping, and cultivar discrimination. The informativeness of a given SSR locus or a loci group depends on the number of alleles, their frequency distribution, as well as the kind of application.
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Microsatellite Instability

New England Journal of Medicine, 2003
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