Results 211 to 220 of about 197,028 (259)

The PRIME trial: An investigator‐initiated, multicentre, phase II study of the poly(ADP‐ribose) polymerase inhibitor olaparib in isocitrate dehydrogenase (IDH)‐mutated relapsed/refractory acute myeloid leukaemia and myelodysplastic syndromes

British Journal of Haematology, EarlyView.
Rory M. Shallis, Jennifer VanOudenhove, Namrata Chandhok, Justin Watts, Deepa Jeyakumar, Daniel R. Reed, Jan Phillip Bewersdorf, Diane Durecki, Scott Boerner, Richard F. Little, Steven D. Gore, Jing Li, Xun Bao, Li Chen, Sayak Ghatak, Thomas Prebet, Ranjit S. Bindra, Amer M. Zeidan, Stephanie Halene   +18 more
wiley   +1 more source

Single‐Cell and Spatial Analysis Reveal the Differences Between Left‐Sided and Right‐Sided Colorectal Cancer

Cell Proliferation, EarlyView.
Single‐cell and spatial analysis revealed distinct CRC microenvironments by tumour laterality. Right‐sided tumours showed enhanced germinal centre B cells, CXCL13+ T cells, and organized TLS‐immune crosstalk via CCL19/21‐CCR7, suggesting better immunotherapy response.
Zongnai Zhang, Jiaqi Xu, Yingchao Wu, Tao Liu, Junling Zhang, Mai Zhou, Jie Qiao, Heng Pan, Xin Wang   +8 more
wiley   +1 more source

Genetic Differentiation Between Black Grouse (<i>Lyrurus tetrix</i>, Linnaeus, 1758) Populations from the Sudetes and the Carpathians. [PDF]

Genes (Basel)
Santorek A, Pałucki A, Zwijacz-Kozica T, Szczepański S, Ciach M, Rutkowski R.   +5 more
europepmc   +1 more source

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Microsatellite Instability-High Somatic-Type Malignancy Arising From a Primary Retroperitoneal Germ Cell Tumor: A Case Report. [PDF]

IJU Case Rep
Hayashi G, Kimura T, Inoue S, Matsuo K, Sano T, Zennami K, Ishida S, Satou A, Akamatsu S.   +8 more
europepmc   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Do aphid endosymbiotic bacteria influence parasitoid searching behaviour through changes in aphid honeydew production?

Ecological Entomology, EarlyView.
Hamiltonella defensa infection increases honeydew production in certain aphid genotypes, potentially modifying aphid feeding behaviour. Parasitoid wasps, Aphidius ervi, are more attracted to honeydew from H. defensa‐infected aphids; though larger honeydew amounts may slightly deter searching.
Desiré Macheda, Alexandre Foito, Katharine F. Preedy, Colin J. Alexander, Ankush Prashar, Alison J. Karley   +5 more
wiley   +1 more source

Genomic Landscape of Early-Onset Colorectal Cancer: A Comparative Analysis With Average-Onset Metastatic Colorectal Cancer in a Real-World NGS Cohort. [PDF]

JCO Precis Oncol
Shin JE, Lee E, Ha SY, Lim SH, Cho YB, Park YS, Lee J, Kim ST.   +7 more
europepmc   +1 more source

Testing the Mediating Role of Social Interactions on the Relationship Between Age and Plumage Traits on Reproductive Success

Ethology, EarlyView.
This conceptual figure uses Directed Acyclic Graphs (DAG) to represent the hypothesized biological mechanism in which age and/or plumage traits affect reproductive success, and social interactions mediate these relationships. It highlights the predicted decomposition of (a) the total effect into the direct and indirect effects under scenarios of (b ...
Zachary M. Laubach, Kayleigh P. Keller, Rebecca J. Safran, Toshi Tsunekage, Iris I. Levin   +4 more
wiley   +1 more source