Results 51 to 60 of about 109,422 (246)

The Genetic Diversity and Population Genetic Structure of the Red Panda, Ailurus fulgens, in Zoos in China

open access: yesAnimals, 2020
In China, red pandas (Ailurus fulgens) have been raised in zoos for 60 years. It is very important to understand the genetic diversity and population genetic structure of the captive red pandas.
Yun-fang Xiu   +4 more
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu   +4 more
wiley   +1 more source

Genetic characterization of Albanian grapevine cultivars by microsatellite markers

open access: yesOENO One, 2005
A recently restored ampelographic collection of Albanian grapevine accessions has been submitted to genetic profiling with eleven nuclear microsatellite markers, widely used in other studies. Microsatellite profiling resulted in 28 single profiles for 29
Emmanuel D. Ladoukakis   +5 more
doaj   +1 more source

PRELID1 and VDAC3 Coordinate a Senescence‐Like State in Germinal Center B Cells to Promote IL‐7–Driven Antitumor Immunity in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
Colorectal cancer is characterized by an immunosuppressive microenvironment that limits immunotherapy efficacy. We identify a senescence‐like state in germinal center B cells driven by the PRELID1–VDAC3 axis, which promotes IL‐7 secretion, alleviates CD8+ T‐cell exhaustion, and enhances antitumor immunity. Targeting this pathway improves responsiveness
Yuhan Liao   +8 more
wiley   +1 more source

Eight Novel Microsatellite Loci in a Declining Grassland Songbird, the Bobolink (Dolichonyx oryzivorus)

open access: yesEcology and Evolution
Microsatellite loci in non‐coding regions of nuclear DNA provide an important tool for genetic diversity research, particularly when comparing relatedness between individuals.
Kathryn McGee   +2 more
doaj   +1 more source

Development and Characterization of 11 Polymorphic Microsatellite Markers in Tapiscia sinensis (Staphyleaceae)

open access: yesApplications in Plant Sciences, 2013
Premise of the study: We developed and characterized five polymorphic microsatellite loci from an AC-enriched genomic library of a rare tree, Tapiscia sinensis, and six compound microsatellite primers using a dual-suppression-PCR–based approach, to ...
Pengfei Zhang   +5 more
doaj   +1 more source

Prognostic and Predictive Role of Lymph Node Count in Stage II Colon Cancer: A Retrospective Analysis of a Japanese Nationwide Cohort

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This study analyzed over 3500 patients with stage II colon cancer treated with D3 lymphadenectomy, to reassess the prognostic value of number of harvested lymph node and their role in predicting benefit from adjuvant chemotherapy using a Japanese nationwide cohort.
Kozo Kataoka   +13 more
wiley   +1 more source

High-Throughput Sequencing Strategy for Microsatellite Genotyping Using Neotropical Fish as a Model

open access: yesFrontiers in Genetics, 2018
Genetic diversity and population studies are essential for conservation and wildlife management programs. However, monitoring requires the analysis of multiple loci from many samples. These processes can be laborious and expensive.
Juliana S. M. Pimentel   +9 more
doaj   +1 more source

Prognostic Impact of Histologic Subtypes in Mismatch Repair‐Deficient/Microsatellite Instability‐High Colorectal Cancer: A Single‐Center Retrospective Study of 1127 Stage 0–IV Patients

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Deficient mismatch repair/microsatellite instability‐High (dMMR/MSI‐H) colorectal cancer (CRC) generally confers a favorable survival yet is paradoxically enriched for poorly differentiated (Por) histology, which is linked to aggressive behavior.
Tomoyuki Momma   +9 more
wiley   +1 more source

Characterization of Hilly Chickens in Consideration of Climate Change Factors: Light and Heat

open access: yesBrazilian Journal of Poultry Science
Hilly chickens were characterized from January 2015 to September 2016 considering climate factors (light and heat). The experimental birds were divided into three groups (heat stress; light and control). The heat was generated in the chicken’s shelter by
MKI Khan   +4 more
doaj   +1 more source

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