Results 51 to 60 of about 140,760 (298)
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Frontiers in Ecology and Evolution, 2023 IntroductionAs anthropogenic change alters and fragments habitats, it is apparent that evolutionary change can co-occur with ecological change, though the scale and consequences of this contemporary evolution remain unclear.
Billie Maguire +5 more
doaj +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Pedigree and marker information requirements to monitor genetic variability
Genetics Selection Evolution, 2003 There are several measures available to describe the genetic variability of populations. The average inbreeding coefficient of a population based on pedigree information is a frequently chosen option.
Johann Sölkner, Roswitha Baumung
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Microsatellites in Cetaceans: An Overview [PDF]
The Open Marine Biology Journal, 2008 This paper presents a comprehensive overview of the published literature on microsatellites studied in cetace- ans from 1989 to 2007. We inventoried 246 loci isolated from 18 and amplified in 51 cetacean species representing 11 families. The majority of loci (68%) were dinucleotide (CA) repeats, which were also shown to be on average more vari- able ...
Bourret, Vincent +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley +1 more source
Comparison of PCR-RFLP and SSR chloroplast markers in study of genetic structure of beech (Fagus orientalis) populations in Hyrcanian forests [PDF]
تحقیقات جنگل و صنوبر ایران, 2006 Chloroplast (cp) DNA polymorphism was analyzed in 14 populations of beech (Fagus orientalis Lipsky) by PCR-RFLP and microsatellite (SSR) chloroplast markers.
Parvin Salehi Shanjani
doaj
Colorectal Cancer "Methylator Phenotype": Fact or Artifact?
Neoplasia: An International Journal for Oncology Research, 2005 It has been proposed that human colorectal tumors can be classified into two groups: one in which methylation is rare, and another with methylation of several loci associated with a "CpG island methylated phenotype (CIMP)," characterized by preferential ...
Charles Anacleto +9 more
doaj +1 more source
Advanced Science, EarlyView.Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song +9 more
wiley +1 more source
Horticultural Science, 2011 The Asturian vineyard is composed mostly of autochthonous minority cultivars only present in the northwest of Spain. This vineyard is characterized by its antiquity, confusion as to the identity of certain cultivars, lack of certified plant material, and
M.D. Loureiro +2 more
doaj +1 more source