Results 51 to 60 of about 309,278 (337)

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

YPR-SLAM: A SLAM System Combining Object Detection and Geometric Constraints for Dynamic Scenes

Sensors
Traditional SLAM systems assume a static environment, but moving objects break this ideal assumption. In the real world, moving objects can greatly influence the precision of image matching and camera pose estimation.
Xukang Kan, Gefei Shi, Xuerong Yang, Xinwei Hu   +3 more
doaj   +1 more source

The geographic distribution of saccharomyces cerevisiae isolates within three Italian neighboring winemaking regions reveals strong differences in yeast abundance, genetic diversity and industrial strain dissemination [PDF]

, 2017
In recent years the interest for natural fermentations has been re-evaluated in terms of increasing the wine terroir and managing more sustainable winemaking practices.
Almeida, Antonangelo, Berger, Borneman, Bovo, Bovo, Bovo, Bruvo, Capece, Coi, Comi, Cordero-Bueso, Cubillos, De Filippo, Di Maio, Diezmann, Erny, Esteve-Zarzoso, Ezov, Fay, Franco-Duarte, Gao, Gayevskiy, Gayevskiy, Huson, Hyma, Johnson, Kamvar, Knight, Kumar, Legras, Legras, Legras, Liti, Lopez, Magwene, Martini, Martiniuk, Mortimer, Nardi, Naumov, Novo, Perez, Querol, Querol, Richards, Robiglio, Ruderfer, Sampaio, Santamaría, Schacherer, Schuller, Schuller, Sipiczki, Sniegowski, Stefanini, Tapsoba, Treu, Valero, Valero, Wang, Weir, Wright, Zhang   +63 more
core   +4 more sources

His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models

Advanced Science, EarlyView.
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li, Tianqi Su, Bin Zhang, Wenkai Han, Sibin Zhang, Guiyin Sun, Yuwei Cong, Xin Chen, Jiping Qi, Yujie Wang, Shiguang Zhao, Hongxue Meng, Peng Liang, Xin Gao   +13 more
wiley   +1 more source

No evidence for a recent genetic bottleneck in the endangered Sheko cattle breed (African Bos taurus) revealed by microsatellite analysis [PDF]

, 2009
Sheko is African taurine cattle, valued for its milk yield, adaptation to humid tsetse infested environment and trypanotolerance. We used 30 microsatellite markers in analyzing 30 DNA samples. We found high genetic diversity and no genetic bottlenecks in
Hailu Dadi, Hirofumi Hanada, Joram Mwacharo, Koh Nomura, Markos Tibbo, Takashi Amano, Yukimizu Takahashi   +6 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Multi-Objective optimization for stable and efficient cargo transportation of partial space elevator

Defence Technology
This paper proposed a new libration decoupling analytical speed function (LD-ASF) in lieu of the classic analytical speed function to control the climber's speed along a partial space elevator to improve libration stability in cargo transportation.
Gefei Shi, Zheng H. Zhu
doaj   +1 more source

Infestation Pattern and Population Dynamics of the Tropical Bed Bug, Cimex hemipterus (F.) (Hemiptera: Cimicidae) Based on Novel Microsatellites and mtDNA Markers

Insects, 2020
The tropical bed bug, Cimex hemipterus (F.), has now emerged as an important public health pest in the tropics. Despite its alarming infestation rate, the information on its population genetics remains scarce. Here, we described the infestation structure
Wan Nur Fatanah Wan Mohammad, Li-Shen Soh, Wan Nurainie Wan Ismail, G. Veera Singham   +3 more
doaj   +1 more source

Ancient origin and maternal inheritance of blue cuckoo eggs [PDF]

, 2016
Maternal inheritance via the female-specific W chromosome was long ago proposed as a potential solution to the evolutionary enigma of co-existing host-specific races (or 'gentes') in avian brood parasites.
Ekrem, Torbjørn, Fossøy, Frode, Liang, Wei, Moksnes, Arne, Møller, Anders P., Rutila, Jarkko, Røskaft, Eivin, Sorenson, Michael D., Stokke, Bård G., Takasu, Fugo, Yang, Canchao   +10 more
core   +3 more sources