Results 1 to 10 of about 124,795 (370)

Genetic changes of MLH1 and MSH2 genes could explain constant findings on microsatellite instability in intracranial meningioma [PDF]

Tumor Biology, 2017
Postreplicative mismatch repair safeguards the stability of our genome. The defects in its functioning will give rise to microsatellite instability. In this study, 50 meningiomas were investigated for microsatellite instability. Two major mismatch repair
Nives Pećina-Šlaus, Anja Kafka, Anja Bukovac, Tomislav Vladušić, Davor Tomas, Reno Hrašćan   +5 more
doaj   +2 more sources

Microsatellite Instability in Malignant Melanoma [PDF]

Cancer Genetics and Cytogenetics, 1998
Defective mismatch repair has been detected in human colorectal and endometrial carcinomas which exhibit microsatellite instability (MIN). The purpose of this study was to search for MIN in melanoma. Paraffin-embedded neoplastic and non-neoplastic control cells were obtained from 20 untreated individuals with cutaneous malignant melanoma.
Vishwas R. Talwalkar, Marc Scheiner, Lora K. Hedges, Merlin G. Butler, Herbert S. Schwartz   +4 more
openalex   +4 more sources

Simple Mathematical Model Of Pathologic Microsatellite Expansions: When Self-Reparation Does Not Work [PDF]

J. Theor. Biol., 2006, v. 242, 401--408, 2007
We propose a simple model of pathologic microsatellite expansion, and describe an inherent self-repairing mechanism working against expansion. We prove that if the probabilities of elementary expansions and contractions are equal, microsatellite expansions are always self-repairing.
Amos, Angers, Barton, Bell, Boris Veytsman, Brinkmann, Brock, Brunner, Calabrese, Calabrese, Cleary, de Gennes, Di Rienzo, Ellegren, Ellegren, FitzSimmons, Garza, Goldstein, Gomes-Pereira, Harper, Harr, Huang, Kayser, Kruglyak, Kruglyak, Lai, Lai, Lai, Leila Akhmadeyeva, Libby, Makova, Mirkin, Monckton, Nielsen, Painter, Pearson, Pearson, Piñeiro, Primmer, Primmer, Schlötterer, Shinde, Shriver, Sibly, Sibly, Tachida, Whittaker, Xu, Yang   +48 more
arxiv   +3 more sources

Microsatellite instability in sacral chordoma [PDF]

Journal of Surgical Oncology, 2000
Microsatellite instability (MIN) is an indirect marker of globally defective DNA mismatch repair in the neoplastic cells of cancer patients. Chordomas are rare, primary skeletal malignancies for which few characteristic molecular genetic markers have been identified.
Lance Klingler, Jeff Shooks, Paul Fiedler, Annis Marney, Merlin G. Butler, Herbert S. Schwartz   +5 more
openalex   +4 more sources

Editorial: Microsatellite and microsatellite instability

Frontiers in Genetics, 2023
Alexandre How-Kit, Kai Ye, Kai Ye, Kai Ye, Kai Ye, Kai Ye   +5 more
doaj   +3 more sources

Microsatellite instability [PDF]

Gut, 1999
Ian M. Frayling
openalex   +4 more sources

Microsatellite instability in multiple colorectal tumors [PDF]

International Journal of Cancer, 1999
Tumor multiplicity is a hallmark of hereditary cancers: in the colon-rectum multiple tumors represent 5-10% of all colorectal cancer cases. A portion of these cases belongs to hereditary non-polyposis colorectal cancer (HNPCC), a genetic cancer syndrome due to mismatch repair (MMR) gene mutations, phenotypically expressed as microsatellite instability (
Monica Pedroni, Maria Grazia Tamassia, Antonio Percesepe, Luca Roncucci, Piero Benatti, Giovanni Lanza, Roberta Gafà, Carmela Di Gregorio, Rossella Fante, Lorena Losi, Luca Gallinari, Francesca Scorcioni, Fabiana Vaccina, Giuseppina Rossi, Anna Maria Cesinaro, Maurizio Ponz de Leòn   +15 more
openalex   +6 more sources

Microsatellite Instability in Colorectal Cancer [PDF]

, 2016
Cancer is a genetic disease. Cancer cells contain various mutations, which includes SNPs to chromosomal aberrations. Together, these changes are referred to as genome instability.
Alanazi, Mohammad Saud, Parine, Narasimha Reddy, Varsha, Reddy Sri   +2 more
core   +5 more sources

Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer [PDF]

Open Medicine
Microsatellite instability (MSI) significantly impacts treatment response and outcomes in colon cancer; however, its underlying molecular mechanisms remain unclear.
Bo Sihan, You Yong, Wang Yongwei, Zhang Yan, Bai Bing, Jiang Tao, Gao Yaxian   +6 more
doaj   +2 more sources

Microsatellite instability: A 2024 update. [PDF]

Cancer Sci
AbstractDeficient mismatch repair (dMMR) results in microsatellite instability (MSI), a pronounced mutator phenotype. High‐frequency MSI (MSI‐H)/dMMR is gaining increasing interest as a biomarker for advanced cancer patients to determine their eligibility for immune checkpoint inhibitors (ICIs). Various methods based on next‐generation sequencing (NGS)
Yamamoto H, Watanabe Y, Arai H, Umemoto K, Tateishi K, Sunakawa Y.   +5 more
europepmc   +3 more sources