Results 1 to 10 of about 859,154 (274)

Editorial: Microsatellite and microsatellite instability

Frontiers in Genetics, 2023
Laboratory for Genomics, Foundation Jean Dausset—CEPH, Paris, France, MOE Key Lab for Intelligent Networks and Networks Security, Faculty of Electronic and Information Engineering, Xi’an Jiaotong University, Xi’an, China, School of Automation Science and
Alexandre How-Kit, Kai Ye, Kai Ye, Kai Ye, Kai Ye, Kai Ye   +5 more
doaj   +2 more sources

Genetic changes of MLH1 and MSH2 genes could explain constant findings on microsatellite instability in intracranial meningioma [PDF]

Tumor Biology, 2017
Postreplicative mismatch repair safeguards the stability of our genome. The defects in its functioning will give rise to microsatellite instability. In this study, 50 meningiomas were investigated for microsatellite instability. Two major mismatch repair
Nives Pećina-Šlaus, Anja Kafka, Anja Bukovac, Tomislav Vladušić, Davor Tomas, Reno Hrašćan   +5 more
doaj   +2 more sources

Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy

Journal of Hematology & Oncology, 2019
Immunotherapies have led to substantial changes in cancer treatment and have been a persistently popular topic in cancer research because they tremendously improve the efficacy of treatment and survival of individuals with various cancer types.
Pengfei Zhao, Li Li, Xiaoyue Jiang, Qin Li   +3 more
doaj   +2 more sources

Simple Mathematical Model Of Pathologic Microsatellite Expansions: When Self-Reparation Does Not Work [PDF]

J. Theor. Biol., 2006, v. 242, 401--408, 2007
We propose a simple model of pathologic microsatellite expansion, and describe an inherent self-repairing mechanism working against expansion. We prove that if the probabilities of elementary expansions and contractions are equal, microsatellite expansions are always self-repairing.
Amos, Angers, Barton, Bell, Boris Veytsman, Brinkmann, Brock, Brunner, Calabrese, Calabrese, Cleary, de Gennes, Di Rienzo, Ellegren, Ellegren, FitzSimmons, Garza, Goldstein, Gomes-Pereira, Harper, Harr, Huang, Kayser, Kruglyak, Kruglyak, Lai, Lai, Lai, Leila Akhmadeyeva, Libby, Makova, Mirkin, Monckton, Nielsen, Painter, Pearson, Pearson, Piñeiro, Primmer, Primmer, Schlötterer, Shinde, Shriver, Sibly, Sibly, Tachida, Whittaker, Xu, Yang   +48 more
arxiv   +3 more sources

Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer [PDF]

Open Medicine
Microsatellite instability (MSI) significantly impacts treatment response and outcomes in colon cancer; however, its underlying molecular mechanisms remain unclear.
Bo Sihan, You Yong, Wang Yongwei, Zhang Yan, Bai Bing, Jiang Tao, Gao Yaxian   +6 more
doaj   +2 more sources

COLORECTAL CANCER: HISTOPATHOLOGICAL PROFILE AND PREVALENCE OF DNA REPAIR SYSTEM DEFICIENCY IN PATIENTS SUBMITTED TO SURGICAL TREATMENT IN A UNIVERSITY HOSPITAL [PDF]

ABCD: Arquivos Brasileiros de Cirurgia Digestiva, 2023
BACKGROUND: Part of colorectal cancer cases occurs due to modifications in the DNA mismatch repair system, which are responsible for microsatellite instability. This alteration results in an unconventional phenotypic pattern of colorectal cancer.
Julia Werner de Oliveira, Raquel Aguirra de Moraes, Samya Hamad Mehanna, Julia Costa Linhares   +3 more
doaj   +1 more source

Genetic Features of Metachronous Esophageal Cancer Developed in Hodgkin's Lymphoma or Breast Cancer Long-Term Survivors: An Exploratory Study. [PDF]

, 2015
Background Development of novel therapeutic drugs and regimens for cancer treatment has led to improvements in patient long-term survival. This success has, however, been accompanied by the increased occurrence of second primary cancers.
Alfieri, R, Amadori, Alberto, Boldrin, E, Cagol, M, Cappellesso, Rocco, Castoro, C, Chiarion Sileni, V, Fassan, Matteo, Rugge, Massimo, Rumiato, E, Ruol, A, Saggioro, D.   +11 more
core   +16 more sources

Pembrolizumab in Patients With Microsatellite Instability–High Advanced Endometrial Cancer: Results From the KEYNOTE-158 Study

Journal of Clinical Oncology, 2022
PURPOSE Pembrolizumab demonstrated durable antitumor activity in patients with previously treated, advanced microsatellite instability–high or mismatch repair–deficient (MSI-H/dMMR) tumors, including endometrial cancer, in the nonrandomized, open-label ...
D. O’Malley, G. Bariani, P. Cassier, A. Marabelle, A. Hansen, A. de Jesus Acosta, W. Miller, T. Safra, A. Italiano, L. Mileshkin, Lei Xu, F. Jin, K. Norwood, M. Maio   +13 more
semanticscholar   +1 more source

Clinical and morphological portrait of tumors with microsatellite instability

Успехи молекулярной онкологии, 2021
Background. Microsatellites are short tandem nucleotide repeats, the change in length of which plays a key roles in the pathogenesis of various malignant neoplasms. This change is called microsatellite instability.
A. A. Musaelyan, V. D. Nazarov, A. S. Budnikova, S. V. Lapin, S. L. Vorobyev, V. L. Emanuel, A. A. Zakharenko, S. V. Orlov   +7 more
doaj   +1 more source

Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study.

Journal of Clinical Oncology, 2020
PURPOSE Genomes of tumors that are deficient in DNA mismatch repair (dMMR) have high microsatellite instability (MSI-H) and harbor hundreds to thousands of somatic mutations that encode potential neoantigens.
A. Marabelle, D. Le, P. Ascierto, A. D. di Giacomo, A. De Jesus-Acosta, J. Delord, R. Geva, M. Gottfried, N. Penel, A. Hansen, S. Piha-Paul, T. Doi, B. Gao, H. Chung, J. López-Martín, Y. Bang, R. S. Frommer, M. Shah, R. Ghori, A. Joe, S. Pruitt, L. Diaz   +21 more
semanticscholar   +1 more source