Genetic changes of MLH1 and MSH2 genes could explain constant findings on microsatellite instability in intracranial meningioma [PDF]
Tumor Biology, 2017 Postreplicative mismatch repair safeguards the stability of our genome. The defects in its functioning will give rise to microsatellite instability. In this study, 50 meningiomas were investigated for microsatellite instability. Two major mismatch repair
Nives Pećina-Šlaus +5 more
doaj +2 more sources
Microsatellite Instability in Malignant Melanoma [PDF]
Cancer Genetics and Cytogenetics, 1998 Defective mismatch repair has been detected in human colorectal and endometrial carcinomas which exhibit microsatellite instability (MIN). The purpose of this study was to search for MIN in melanoma. Paraffin-embedded neoplastic and non-neoplastic control cells were obtained from 20 untreated individuals with cutaneous malignant melanoma.
Vishwas R. Talwalkar +4 more
openalex +4 more sources
Editorial: Microsatellite and microsatellite instability
Frontiers in Genetics, 2023 Alexandre How-Kit +5 more
doaj +3 more sources
Microsatellite instability in multiple colorectal tumors [PDF]
International Journal of Cancer, 1999 Tumor multiplicity is a hallmark of hereditary cancers: in the colon-rectum multiple tumors represent 5-10% of all colorectal cancer cases. A portion of these cases belongs to hereditary non-polyposis colorectal cancer (HNPCC), a genetic cancer syndrome due to mismatch repair (MMR) gene mutations, phenotypically expressed as microsatellite instability (
Monica Pedroni +15 more
openalex +6 more sources
Microsatellite instability in sacral chordoma [PDF]
Journal of Surgical Oncology, 2000 Microsatellite instability (MIN) is an indirect marker of globally defective DNA mismatch repair in the neoplastic cells of cancer patients. Chordomas are rare, primary skeletal malignancies for which few characteristic molecular genetic markers have been identified.
Lance Klingler +5 more
openalex +4 more sources
Microsatellite Instability and BAT-26 Marker Expression in a Mexican Prostate Cancer Population with Different Gleason Scores [PDF]
DiseasesBackground/Objectives: Prostate cancer (PCa) is one of the most common cancers in men worldwide. While standard treatments often provide good initial results, many patients eventually develop resistance and experience a more aggressive relapse ...
Ana K. Flores-Islas +9 more
doaj +2 more sources
Genetic Features of Metachronous Esophageal Cancer Developed in Hodgkin's Lymphoma or Breast Cancer Long-Term Survivors: An Exploratory Study. [PDF]
, 2015 Background Development of novel therapeutic drugs and regimens for cancer treatment has led to improvements in patient long-term survival. This success has, however, been accompanied by the increased occurrence of second primary cancers.
Alfieri, R +11 more
core +9 more sources
Clinical and morphological portrait of tumors with microsatellite instability
Успехи молекулярной онкологии, 2021 Background. Microsatellites are short tandem nucleotide repeats, the change in length of which plays a key roles in the pathogenesis of various malignant neoplasms. This change is called microsatellite instability.
A. A. Musaelyan +7 more
doaj +1 more source
Microsatellite instability in colorectal cancer [PDF]
Asia-Pacific Journal of Clinical Oncology, 2010 AbstractApproximately 20 percent of right‐sided colon cancers and 5 percent of left‐sided colon and rectal cancers have a deficient DNA mismatch repair system. This results in the widespread accumulation of mutations to nucleotide repeats, some of which occur within the coding regions of cancer‐related genes such as TGFβRII and BAX.
Iacopetta, Barry +2 more
openaire +7 more sources