Results 1 to 10 of about 55,423 (289)

Endoscopic features of deficient mismatch repair/microsatellite instability-high and BRAF-mutated colorectal cancer. [PDF]

DEN Open
Abstract Objective Recent advancements in genome analyses, including the BRAF gene and mismatch repair (MMR) gene/microsatellite instability (MSI), have revealed the biological diversity of colorectal cancer (CRC). BRAF‐mutated CRC has a poor prognosis; however, cases exhibiting deficient MMR (dMMR)/MSI‐high (MSI‐H) and BRAF gene mutations have ...
Omote R, Omote S, Sumii R, Horii J, Fujita I, Miyaso H, Toyokawa T, Inagaki M.   +7 more
europepmc   +4 more sources

Evaluating MRI response criteria in microsatellite instability-high rectal cancer treated with immune checkpoint inhibitors. [PDF]

ESMO Open
Vanderbecq Q, Cohen R, Camus M, Dray X, Parc Y, André T, Wagner M.   +6 more
europepmc   +2 more sources

Successful Conversion Surgery for Unresectable Microsatellite Instability-High Pancreatic Tail Cancer Following Pembrolizumab Therapy. [PDF]

Surg Case Rep
Harada N, Kurata M, Seyama Y, Shirata C, Okinaga H, Okuya T, Suzuki M, Horiguchi S.   +7 more
europepmc   +3 more sources

Microsatellite Instability in Keratoacanthoma [PDF]

Cancer, 1995
Tumors from patients with hereditary nonpolyposis colorectal cancer (HNPCC) and from a subset of patients with the related Muir-Torre syndrome (MTS) exhibit a novel type of genomic instability known as microsatellite instability (MIN). In general, this form of genomic instability results from mutations that inactivate DNA mismatch repair genes.
K C, Halling, R, Honchel, M R, Pittelkow, S N, Thibodeau   +3 more
openaire   +2 more sources

Microsatellite instability in sarcomas [PDF]

Annals of Surgical Oncology, 1998
Microsatellite instability (MIN) has been studied in a variety of carcinomas and gynecologic sarcomas, but never in musculoskeletal sarcomas.We evaluated 16 skeletal and soft tissue sarcomas at nine genetic loci from chromosomal regions 1q, 5q, 7q, 12p, 13q, 17p, 19q, and two at 11p--all potential regions of interest regarding musculoskeletal sarcomas ...
S S, Martin, W G, Hurt, L K, Hedges, M G, Butler, H S, Schwartz   +4 more
openaire   +2 more sources

Microsatellite instability in colorectal cancer [PDF]

Asia-Pacific Journal of Clinical Oncology, 2010
AbstractApproximately 20 percent of right‐sided colon cancers and 5 percent of left‐sided colon and rectal cancers have a deficient DNA mismatch repair system. This results in the widespread accumulation of mutations to nucleotide repeats, some of which occur within the coding regions of cancer‐related genes such as TGFβRII and BAX.
Barry, Iacopetta, Fabienne, Grieu, Benhur, Amanuel   +2 more
openaire   +5 more sources

Microsatellite instability in colorectal cancer [PDF]

Radiology and Oncology, 2011
Colorectal cancer (CRC) is the third most common cancer in the world. In 75% CRC develops sporadically, in 25% hereditary or as a consequence of inflammatory bowel disease. CRC carcinogenesis develops over many years. The cause of CRC in 85% is chromosomal instability (CIN) and in 15% microsatellite instability (MSI-H), where hereditary nonpolyposis ...
Horvat, Matej, Štabuc, Borut
openaire   +4 more sources

Microsatellite Instability in Malignant Melanoma [PDF]

Cancer Genetics and Cytogenetics, 1998
Defective mismatch repair has been detected in human colorectal and endometrial carcinomas which exhibit microsatellite instability (MIN). The purpose of this study was to search for MIN in melanoma. Paraffin-embedded neoplastic and non-neoplastic control cells were obtained from 20 untreated individuals with cutaneous malignant melanoma.
V R, Talwalkar, M, Scheiner, L K, Hedges, M G, Butler, H S, Schwartz   +4 more
openaire   +2 more sources

Microsatellite instability in colorectal cancer

EXCLI journal, 2018
EXCLI Journal; 17:Doc159; ISSN 1611 ...
Nojadeh, Jafar Nouri, Sharif, Shahin Behrouz, Sakhinia, Ebrahim   +2 more
openaire   +6 more sources

Microsatellite instability in sacral chordoma [PDF]

Journal of Surgical Oncology, 2000
Microsatellite instability (MIN) is an indirect marker of globally defective DNA mismatch repair in the neoplastic cells of cancer patients. Chordomas are rare, primary skeletal malignancies for which few characteristic molecular genetic markers have been identified.
L, Klingler, J, Shooks, P N, Fiedler, A, Marney, M G, Butler, H S, Schwartz   +5 more
openaire   +2 more sources