Results 1 to 10 of about 89,549 (187)

Genetic changes of MLH1 and MSH2 genes could explain constant findings on microsatellite instability in intracranial meningioma [PDF]

Tumor Biology, 2017
Postreplicative mismatch repair safeguards the stability of our genome. The defects in its functioning will give rise to microsatellite instability. In this study, 50 meningiomas were investigated for microsatellite instability. Two major mismatch repair
Bukovac, Anja, Hrašćan, Reno, Kafka, Anja, Pećina-Šlaus, Nives, Tomas, Davor, Vladušić, Tomislav   +5 more
core   +2 more sources

Microsatellite Instability and BAT-26 Marker Expression in a Mexican Prostate Cancer Population with Different Gleason Scores. [PDF]

Diseases
Background/Objectives: Prostate cancer (PCa) is one of the most common cancers in men worldwide. While standard treatments often provide good initial results, many patients eventually develop resistance and experience a more aggressive relapse ...
Flores-Islas AK, Rico-Méndez MA, Godínez-Rubí M, Villanueva-Pérez MA, Sierra-Díaz E, Pereira-Suárez AL, Beltrán-Ontiveros SA, Gutiérrez-Arzapalo PY, Moreno-Ortiz JM, Ramírez-de-Arellano A.   +9 more
europepmc   +2 more sources

Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer. [PDF]

Open Med (Wars)
Microsatellite instability (MSI) significantly impacts treatment response and outcomes in colon cancer; however, its underlying molecular mechanisms remain unclear.
Bo S, You Y, Wang Y, Zhang Y, Bai B, Jiang T, Gao Y.   +6 more
europepmc   +2 more sources

Genetic Features of Metachronous Esophageal Cancer Developed in Hodgkin's Lymphoma or Breast Cancer Long-Term Survivors: An Exploratory Study. [PDF]

, 2015
Background Development of novel therapeutic drugs and regimens for cancer treatment has led to improvements in patient long-term survival. This success has, however, been accompanied by the increased occurrence of second primary cancers.
Alfieri, R, Amadori, Alberto, Boldrin, E, Cagol, M, Cappellesso, Rocco, Castoro, C, Chiarion Sileni, V, Fassan, Matteo, Rugge, Massimo, Rumiato, E, Ruol, A, Saggioro, D.   +11 more
core   +9 more sources

Clinical and morphological portrait of tumors with microsatellite instability

Успехи молекулярной онкологии, 2021
Background. Microsatellites are short tandem nucleotide repeats, the change in length of which plays a key roles in the pathogenesis of various malignant neoplasms. This change is called microsatellite instability.
A. A. Musaelyan, V. D. Nazarov, A. S. Budnikova, S. V. Lapin, S. L. Vorobyev, V. L. Emanuel, A. A. Zakharenko, S. V. Orlov   +7 more
doaj   +1 more source

DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy [PDF]

, 2014
Colorectal cancers (CRC) are thought to have genetic instability in the form of either microsatellite instability (MSI) or chromosomal instability (CIN).
Abdel-Rahman, Araujo, Armitage, Baba, Bertagnolli, Curtis, Dhadda, Dhadda, Fadhil, Fadhil, Fearon, Fisher, Flyger, Fodde, Frei, Georgiades, Goh, Hadjihannas, Hawkins, Hedley, Heimann, Hutchins, Ilyas, Ingh, Jass, Karran, Kouri, Levitt, Lothe, Michelassi, Ormerod, Palles, Pino, Pritchard, Quirke, Rajagopalan, Ribic, Sieber, Silver, Suarez, Tang, The Cancer Genome Atlas Network, Thibodeau, Vecchio, Williams   +44 more
core   +4 more sources

Dramatic response to pembrolizumab after pseudoprogression in a patient with advanced metastatic castration‐resistant prostate cancer

IJU Case Reports, 2022
Introduction Prostate cancer with a microsatellite instability‐high or mismatch repair‐deficient status is not common. Few reports of the response to pembrolizumab in metastatic castration‐resistant prostate cancer in a real‐world setting have been ...
Takumi Kageyama, Norihito Soga, Sho Sekito, Seiichi Kato, Yuji Ogura, Takahiro Kojima, Masahiro Kanai, Takahiro Inoue   +7 more
doaj   +1 more source

Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy

Libri Oncologici, 2023
Gastric cancer remains one of the deadliest types of cancer despite the improvements in therapy regimens. The knowledge about specific molecular and histopathologic features of gastric tumors leads toward targeted therapy protocols.
Suzana Janković, Snježana Ramić, Tomislav Kelava, Zvonimir Misir, Iva Kirac, Goran Glavčić, Jakša Filipović-Čugura   +6 more
doaj   +1 more source

Long response duration to pembrolizumab in metastatic, castration-resistant prostate cancer with microsatellite instability-high and neuroendocrine differentiation: A case report

Frontiers in Oncology, 2022
BackgroundThe detection of microsatellite instability in urologic cancers is rare, especially in metastatic, castration-resistant prostate cancer with neuroendocrine differentiation.Case presentationThis is a case of a 66-year-old Asian male patient with
Tsukasa Yoshida, Hiroshi Yaegashi, Ren Toriumi, Suguru Kadomoto, Hiroaki Iwamoto, Kouji Izumi, Yoshifumi Kadono, Hiroko Ikeda, Atsushi Mizokami   +8 more
doaj   +1 more source

Relationship between protein biomarkers of chemotherapy response and microsatellite status, tumor mutational burden and PD-L1 expression in cancer patients. [PDF]

, 2020
Chemotherapy and checkpoint inhibitor immunotherapies are increasingly used in combinations. We determined associations between the presence of anti-PD-1/PD-L1 therapeutic biomarkers and protein markers of potential chemotherapy response.
Arguello, David, Barkauskas, Donald A, Gatalica, Zoran, Kurzrock, Razelle, Nikanjam, Mina, Swensen, Jeff   +5 more
core   +2 more sources