Results 111 to 120 of about 859,289 (399)

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion [PDF]

, 2013
PMCID: PMC3544714This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
Ahmed, S, Cazier, J-B, Dorudi, S, Feakins, R, Ghosh, A, Gibbs, P, Lai, C, Mouradov, D, Polanco-Echeverry, G, Propper, D, Sakthianandeswaren, A, Sengupta, N, Sieber, O, Silver, A, Suraweera, N, Thaha, M, Yau, C   +16 more
core   +4 more sources

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

Molecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang, Anna Schritz, Nikolai Goncharenko, Guy Berchem   +3 more
wiley   +1 more source

Instability of a dinucleotide repeat in the 3′‐untranslated region (UTR) of the microsomal prostaglandin E synthase‐1 (mPGES‐1) gene in microsatellite instability‐high (MSI‐H) colorectal carcinoma

Molecular Oncology, 2015
DNA mismatch‐repair gene mutations, with consequent loss of functional protein expression, result in microsatellite instability (MSI). Microsatellite sequences are found in coding regions and in regulatory regions of genes (i.e., 5′‐UTRs and 3′‐UTRs). In
Durga Prasad Cherukuri, Joshua L. Deignan, Kingshuk Das, Wayne W. Grody, Harvey Herschman   +4 more
doaj   +1 more source

Biomaterial-induced sarcomagenesis is not associated with microsatellite instability [PDF]

, 2018
Sarcomagenesis, in contrast to carcinogenesis, is poorly understood. Microsatellite instability has been implicated in the development of many cancers, in particular those associated with chronic inflammatory conditions.
Hansen, Torsten, Kirkpatrick, C., Schad, Arno, Springer, Erik, Strehl, Annette, Weber, Achim   +5 more
core  

Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis [PDF]

Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned.
A Di Giorgio, A Hemminki, A Loukola, AC Lazaris, B Curran, C B Diep, CM Wright, CR Boland, E-S Chang, G Bardi, G I Meling, GI Meling, H Elsaleh, H Kim, I Sæterdal, J Gutierrez, J Jass, J Klein, J Ruschoff, JM Michael-Robinson, JR Jass, JR Jass, JR Lukish, JT Johannsdottir, KC Halling, KM Feeley, KM Ropponen, KW Kinzler, L Messerini, L Thorstensen, L Thorstensen, LA Aaltonen, M Guidoboni, M Kunihiro, M Morita, MJ Massa, P Brandtzaeg, PH Rooney, PM De Angelis, R A Lothe, R Dolcetti, R Gryfe, R Ward, RA Lothe, S N Andersen, S Norheim Andersen, S Salahshor, S Senba, SN Thibodeau, SN Thibodeau, T Løvig, T O Rognum, T Watanabe, TC Smyrk, TO Rognum, TO Rognum, TO Rognum, VJ Bubb, XP Zhou, Y Ionov, Y Naito   +60 more
core   +2 more sources

Genomic instability in human cancer: molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition [PDF]

, 2015
Genomic instability can initiate cancer, augment progression, and influence the overall prognosis of the affected patient. Genomic instability arises from many different pathways, such as telomere damage, centrosome amplification, epigenetic ...
Amedei, Amedeo, Amin, Amr, Aquilano, Katia, Ashraf, S. Salman, Azmi, Asfar S., Bhakta, Dipita, Bilsland, Alan, Boosani, Chandra S., Chen, Helen, Chen, Sophie, Ciriolo, Maria Rosa, Collins, Andrew R., Connell, Marisa, Damia, Giovanna, Dasgupta, Santanu, Ferguson, Lynnette R., Fujii, Hiromasa, Guha, Gunjan, Halicka, Dorota, Helferich, William G., Honoki, Kanya, Keith, W. Nicol, Malhotra, Meenakshi, Maxwell, Christopher A., Meeker, Alan K., Mohammed, Sulma I., Niccolai, Elena, Parslow, Virginia R., Prakash, Satya, Rezazadeh, Sarallah, Shackelford, Rodney E., Sidransky, David, Tran, Phuoc T., Yang, Eddy S., Yang, Xujuan   +34 more
core   +1 more source

A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability

Cancer Research, 2020
These findings demonstrate the feasibility of an “off the shelf” vaccine for treatment and prevention of tumors harboring frameshift mutations and neoantigenic peptides as a result of microsatellite instability.
G. Leoni, A. D’Alise, G. Cotugno, F. Langone, I. Garzia, Maria De Lucia, Imma Fichera, Rosa Vitale, Veronica Bignone, Fabio Giovanni Tucci, F. Mori, Adriano Leuzzi, Elena Di Matteo, F. Troise, A. Abbate, R. Merone, Valentino Ruzza, M. Diodoro, M. Yadav, Mónica Gordón-Alonso, Cristophe Vanhaver, M. Panigada, E. Soprana, A. Siccardi, A. Folgori, S. Colloca, P. van der Bruggen, A. Nicosia, A. Lahm, M. Catanese, E. Scarselli   +30 more
semanticscholar   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

Microsatellite instability states serve as predictive biomarkers for tumors chemotherapy sensitivity

iScience, 2023
Summary: There is an urgent need for markers to predict the efficacy of different chemotherapy drugs. Herein, we examined whether microsatellite instability (MSI) status can predict tumor multidrug sensitivity and explored the underlying mechanisms.
Taojun Ye, Anqi Lin, Zhengang Qiu, Shulu Hu, Chaozheng Zhou, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo   +8 more
doaj