Results 111 to 120 of about 50,169 (235)

Finding More in Less: Precision Medicine for Pancreatic Cancer Using Residual Cytology Samples

Cytopathology, EarlyView.
The study evaluates the use of residual liquid‐based cytology (LBC) samples from pancreatic ductal adenocarcinoma (PDAC) for molecular analysis. It shows that LBC samples preserve nucleic acid quality and remain suitable for next‐generation sequencing (NGS) and MSI testing even after prolonged storage, underscoring their value when other samples are ...
Raquel Antón‐Peñalver, María Ortega, Jose Francisco González‐Muñoz, Desamparados Compañ, Constanza Galindo, Clara Arnau, Marisol Huerta, Valentina Gambardella, Desamparados Roda, Rosana Villagrasa, Vicente Sanchiz, Andrés Peña, Elena Muñoz‐Forner, Isabel Mora Oliver, Luis Sabater, Andrés Cervantes, Antonio Ferrández, Clara Alfaro‐Cervelló   +17 more
wiley   +1 more source

Evaluating the Impact of Putative Metformin Targets on Cancer Outcomes: A Drug‐Target Mendelian Randomization Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Observational studies show metformin use associated with lower cancer risk, although experimental evidence is inconsistent. To provide genetic validation for repositioning of metformin in cancer prevention, we assessed genetically proxied effects of putative metformin targets on cancer outcomes using a drug‐target Mendelian randomization (
Xingyu Shen, Shan Luo, Jie Zheng, Celine Sze Ling Chui, Ian Chi Kei Wong, Eric Yuk Fai Wan, Catherine Mary Schooling, Shiu Lun Au Yeung   +7 more
wiley   +1 more source

Human papilloma virus infection and mismatch repair protein expression in sebaceous neoplasms of the genital area

Histopathology, EarlyView.
This study establishes the role of high‐risk HPV infection in cutaneous sebaceous carcinoma of the genital area. An intraepithelial component in a subset of cases poses a challenge to distinguish the entity from squamous cell carcinoma in situ. Rarely, sebaceous neoplasia of the genital area is associated with Muir–Torre syndrome. Aims This study aimed
Katharina Wiedemeyer, Zainab Al‐Shamma, Martin Köbel, Ingrid Ferreira, Paul W. Harms, Thomas Brenn   +5 more
wiley   +1 more source

No Evidence of Microsatellite Instability in Head and Neck Squamous Cell Carcinoma of Non‐Smokers and Non‐Drinkers

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Introduction While the prevalence of microsatellite instability (MSI) is low in the whole head and neck squamous cell carcinoma (HNSCC) population, it has been suggested to be more prominent in tumors of non‐smokers. Therefore, the goal of this study was to determine the presence of MSI in a cohort of well‐defined HNSCC of non‐smokers and non ...
F. J. Mulder, T. F. B. Gielgens, E. J. de Ruiter, R. de Bree, M. F. C. M. van den Hout, B. Kremer, S. M. Willems, E. J. M. Speel   +7 more
wiley   +1 more source

Exploring the nexus: Clinical and physiological correlation between cardiovascular disease and colorectal cancer

Experimental Physiology, EarlyView.
Abstract Colorectal cancer (CRC) and cardiovascular disease (CVD) are leading causes of morbidity and mortality worldwide, traditionally studied as distinct pathologies. However, emerging evidence suggests a significant physiological and molecular overlap between these conditions, indicating that they might share common pathophysiological pathways. The
Mohamad Bashir, Ali Murtada, Matti Jubouri, Wael Awad, Ian Williams, Damian M. Bailey   +5 more
wiley   +1 more source

Systemic inflammatory response in colorectal cancer is associated with tumour mismatch repair and impaired survival

Scientific Reports
The systemic inflammatory response (SIR), defined as elevated levels of circulating C-reactive protein (CRP), is an important predictor of impaired survival in colorectal cancer.
Mats Hjortborg, Sofia Edin, Camilla Böckelman, Tuomas Kaprio, Xingru Li, Ioannis Gkekas, Jaana Hagström, Karin Strigård, Caj Haglund, Ulf Gunnarsson, Richard Palmqvist   +10 more
doaj   +1 more source

Metabolic‐immune interactions in gastric cancer T cells: A single‐cell atlas for prognostic biomarker identification

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Metabolic alterations and immune dysfunction within the gastric tumor microenvironment critically drive gastric cancer (GC) progression and therapeutic resistance. Although single‐cell RNA sequencing (scRNA‐seq) has unveiled cellular heterogeneity in GC, the metabolic landscapes of tumor cells and their interplay with immune components remain ...
Junjun Liu, Rui Zhao, Guodong Yao, Zhao Liu, Runze Shi, Jingshu Geng, Guanying Liang, Kexin Chen   +7 more
wiley   +1 more source

Microsatellite instability in aborted embryos [PDF]

Molecular Human Reproduction, 1996
H, Kiaris, E, Koumantakis, M, Ergazaki, D A, Spandidos   +3 more
openaire   +2 more sources

Exercise serum promotes DNA damage repair and remodels gene expression in colon cancer cells

International Journal of Cancer, Volume 158, Issue 10, Page 2641-2649, 15 May 2026.
What's New? Exercise releases bioactive molecules into the bloodstream that can directly slow cancer cell growth. In colon cancer, this may help limit disease progression. Here, using colon cancer cells, the authors investigated the effects of exercise‐conditioned human serum on DNA repair mechanisms. Notably, acute exercise in humans elicited systemic
Samuel T. Orange, Emily Dodd, Sharanya Nath, Hannah Bowden, Alastair R. Jordan, Hannah Tweddle, Ann Hedley, Ifeoma Chukwuma, Ian Hickson, Sweta Sharma Saha   +9 more
wiley   +1 more source

Distribution and prognostic value of T‐cells in primary colorectal cancer and adjacent non‐tumor mucosa in stage IV versus stage I–III patients

International Journal of Cancer, Volume 158, Issue 10, Page 2760-2770, 15 May 2026.
What's New? While colonic mucosa lymphocytes have been quantified in the context of inflammatory diseases, T‐cells in non‐tumor mucosa adjacent to colorectal cancer remain understudied. This study found that in stage IV colorectal cancer (synchronous liver metastasis), higher Foxp3+ T‐cell density and Foxp3+/CD4+ and Foxp3+/CD8+ T‐cell ratios in non ...
Esraa Ali, Wenjing Ye, Sergii Pavlov, Lenka Červenková, Filip Ambrozkiewicz, Ondřej Vyčítal, Petr Hošek, Ondřej Daum, Václav Liška, Kari Hemminki, Andriy Trailin   +10 more
wiley   +1 more source