Results 111 to 120 of about 124,795 (370)

An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer

Advanced Science, EarlyView.
This study presents an explainable multimodal AI model, MAIGGT (Multimodal Artificial Intelligence Germline Genetic Testing), that combines whole‐slide histopathology with clinical data for accurate germline BRCA1/2 mutation prescreening. By integrating digital pathology and EHR phenotypes, MAIGCT enables cost‐effective, scalable hereditary breast ...
Zijian Yang, Changyuan Guo, Jiayi Li, Yalun Li, Lei Zhong, Pengming Pu, Tongxuan Shang, Lin Cong, Yongxin Zhou, Guangdong Qiao, Ziqi Jia, Hengyi Xu, Heng Cao, Yansong Huang, Tianyi Liu, Jian Liang, Jiang Wu, Dongxu Ma, Yuchen Liu, Ruijie Zhou, Xiang Wang, Jianming Ying, Meng Zhou, Jiaqi Liu   +23 more
wiley   +1 more source

Microsatellite instability in Marek’s Disease Virus infected primary chicken embryo fibroblasts

Virology Journal, 2012
Background Marek’s disease virus (MDV), an oncogenic α-herpes virus, causes a devastating disease in chickens characterized by development of lymphoblastoid tumors in multiple organs.
Zhou Zhenlei, Yao Dawei, Qiu Yan, Yang Deji   +3 more
doaj   +1 more source

Integrative Pan-Cancer Analysis of RNMT: a Potential Prognostic and Immunological Biomarker [PDF]

arXiv, 2022
Background: RNA guanine-7 methyltransferase (RNMT) is one of the main regulators of N7-methylguanosine, and the deregulation of RNMT correlated with tumor development and immune metabolism. However, the specific function of RNMT in pan-cancer remains unclear.
arxiv  

Programmed cell death and genetic stability in conifer embryogenesis [PDF]

, 2007
Somatic embryogenesis, the generation of embryos from somatic cells, is a valuable tool for studying embryology. In addition, somatic embryos can be used for large-scale vegetative propagation, an application of great interest for forestry.
Helmersson, Andreas
core  

Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT) [PDF]

, 2011
The purpose of this study was to analyze the detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT). Data for a total of 492 patients who had undergone both PET/CT
A Katagiri, B Levin, BR Weston, CD Johnson, CG Fraser, D Ravizza, D Thorwarth, DF Halpenny, Eisuke Kaji, EM Kamel, EM Rohren, F Gutman, FA Sinicrope, H Pohl, Hideyuki Suzuki, J Czernin, JP Drenth, Jun Kato, Kazuhide Yamamoto, Keisuke Hori, KS Tagore, MB Tessem, MC Kouwen van, Mitsuhiro Akita, O Israel, PL Kei, R Meza, R Minamimoto, R Tatlidil, Reiji Higashi, S Friedland, S Halligan, S Kudo, S Kudo, S Tsuda, S Yasuda, Sakiko Hiraoka, Sakuma Takahashi, Shunsuke Saito, SS Shim, TF Imperiale, Tomoko Hirakawa, Toshio Uraoka, WS Samowitz, Y Zhao, Yoshihiro Okumura   +45 more
core   +1 more source

Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases

Annals of Gastroenterological Surgery, EarlyView.
Preoperative GPS2 is an independent poor prognostic factor in patients with colorectal cancer and synchronous peritoneal metastases, and surgical resection does not improve prognosis in patients with GPS2. Preoperative GPSs may be used as indicators for surgical resection of synchronous peritoneal metastases.
Kosuke Fujimoto, Fumikazu Koyama, Hirotoshi Kobayashi, Kenjiro Kotake, Masayasu Kawasaki, Yukihide Kanemitsu, Yusuke Kinugasa, Hideki Ueno, Kotaro Maeda, Takeshi Suto, Michio Itabashi, Kimihiko Funahashi, Heita Ozawa, Shingo Noura, Hideyuki Ishida, Masayuki Ohue, Tomomichi Kiyomatsu, Soichiro Ishihara, Keiji Koda, Hideo Baba, Kenji Kawada, Yojiro Hashiguchi, Takanori Goi, Yuji Toiyama, Naohiro Tomita, Eiji Sunami, Fumihiko Fujita, Jun Watanabe, Kenichi Hakamada, Goro Nakayama, Kenichi Sugihara, Yoichi Ajioka   +31 more
wiley   +1 more source

Assembly of female and male hihi genomes (stitchbird; Notiomystis cincta) enables characterization of the W chromosome and resources for conservation genomics

Molecular Ecology Resources, EarlyView., 2023
Abstract A high‐quality reference genome can be a valuable resource for threatened species by providing a foundation to assess their evolutionary potential to adapt to future pressures such as environmental change. We assembled the genome of a female hihi (Notiomysits cincta), a threatened passerine bird endemic to Aotearoa New Zealand.
Sarah Bailey, Joseph Guhlin, Dinindu S. Senanayake, Phoebe Scherer, Patricia Brekke, John G. Ewen, Anna W. Santure, Annabel Whibley   +7 more
wiley   +1 more source

Znaczenie mechanizmu naprawy DNA błędnie sparowanych zasad azotowych (MMR) w raku piersi

Menopause Review, 2010
Background: Microsatellite instability (MSI) is due to defective DNA mismatch repair. Defects in DNA mismatch-repair (MMR) genes lead to replication errors revealed as instability in microsatellite markers.
Hanna Romanowicz, Beata Smolarz, Tomasz Fiks, Andrzej Kulig, Ireneusz Połać, Anna Sobczuk, Tomasz Pertyński   +6 more
doaj  

Prevalence of established and emerging biomarkers of immune checkpoint inhibitor response in advanced hepatocellular carcinoma. [PDF]

, 2019
The clinical deployment of immune checkpoint inhibitors (ICIs) has created a tandem drive for the identification of biomarkers linked to benefit. Comprehensive genomic profiling was performed to evaluate the frequency of genomic biomarkers of ICI ...
Ali, Siraj M, Ang, Celina, Fabrizio, David, Goodman, Aaron, Klempner, Samuel J, Kurzrock, Razelle, Madison, Russell, Millis, Sherri Z, Ross, Jeffrey S, Severson, Eric A, Suh, James   +10 more
core   +1 more source

Microsatellite Instability and Colorectal Cancer

Archives of Pathology & Laboratory Medicine, 2011
Context.—About 15% of colorectal cancers are characterized by genomic microsatellite instability, and of these, about 1 in 5 (2%–4% overall) are due to Lynch syndrome, a dominantly inherited condition predisposing the patient to cancers of multiple organ systems, including the gastrointestinal tract.
Wade S. Samowitz, Katherine B. Geiersbach   +1 more
openaire   +2 more sources