Results 111 to 120 of about 55,423 (289)
Cancer Science, EarlyView.In this study, we investigated the predictive value of tumor mutational burden (TMB) for assessing the efficacy of pembrolizumab in a Japanese cohort. We analyzed real‐world data from 63,952 patients registered in the C‐CAT database who underwent comprehensive genomic profiling, and evaluated the therapeutic efficacy of pembrolizumab in 1899 of these ...
Tomoyo Yasuda +7 more
wiley +1 more source
Finding More in Less: Precision Medicine for Pancreatic Cancer Using Residual Cytology Samples
Cytopathology, EarlyView.The study evaluates the use of residual liquid‐based cytology (LBC) samples from pancreatic ductal adenocarcinoma (PDAC) for molecular analysis. It shows that LBC samples preserve nucleic acid quality and remain suitable for next‐generation sequencing (NGS) and MSI testing even after prolonged storage, underscoring their value when other samples are ...
Raquel Antón‐Peñalver +17 more
wiley +1 more source
Histopathology, EarlyView.This study establishes the role of high‐risk HPV infection in cutaneous sebaceous carcinoma of the genital area. An intraepithelial component in a subset of cases poses a challenge to distinguish the entity from squamous cell carcinoma in situ. Rarely, sebaceous neoplasia of the genital area is associated with Muir–Torre syndrome. Aims This study aimed
Katharina Wiedemeyer +5 more
wiley +1 more source
Novel Liquid Biopsy in Gastrointestinal Cancers
Journal of Gastroenterology and Hepatology, EarlyView.ABSTRACT Gastrointestinal (GI) cancers represent a significant global health burden, being among the leading causes of cancer‐related deaths. The prognosis for patients remains unsatisfactory, largely because most cancers are detected at advanced stages.
Li‐Chun Chang +2 more
wiley +1 more source
Pathology and Oncology ResearchIntroduction/backgroundGastric carcinomas (GC) are heterogeneous malignancies characterised by distinct histological and molecular subtypes. The microsatellite instability (MSI) molecular subtype, resulting from deficient DNA mismatch repair (dMMR ...
Ntebogeng Kgokong +9 more
doaj +1 more source
Microsatellite instability in colorectal cancer
Indian Journal of Pathology and MicrobiologyABSTRACT Background: To investigate relationships between microsatellite instability (MSI) and the clinicopathological characteristics of colorectal cancer (CRC) to facilitate the provision of targeted therapy and immunotherapy for CRC related to MSI, and provide a basis for better prognoses.
Xiao Y, Chen +4 more
openaire +2 more sources
Journal of Oral Pathology &Medicine, EarlyView.ABSTRACT Introduction While the prevalence of microsatellite instability (MSI) is low in the whole head and neck squamous cell carcinoma (HNSCC) population, it has been suggested to be more prominent in tumors of non‐smokers. Therefore, the goal of this study was to determine the presence of MSI in a cohort of well‐defined HNSCC of non‐smokers and non ...
F. J. Mulder +7 more
wiley +1 more source
Colorectal cancers and microsatellite instability
Colorectal cancer (CRC) is a multifactorial disease arising from the complex interplay between genetic predisposition and environmental influences. Despite its widespread incidence globally, CRC demon strates favorable prognostic outcomes when detected at an early stage. Microsatellite instability (MSI) is a common molecular abnormality associated with
Esmkhani, Sahra +7 more
openaire +3 more sources
Experimental Physiology, EarlyView.Abstract Colorectal cancer (CRC) and cardiovascular disease (CVD) are leading causes of morbidity and mortality worldwide, traditionally studied as distinct pathologies. However, emerging evidence suggests a significant physiological and molecular overlap between these conditions, indicating that they might share common pathophysiological pathways. The
Mohamad Bashir +5 more
wiley +1 more source