Results 161 to 170 of about 859,289 (399)

Microsatellite instability status determined by next‐generation sequencing and compared with PD‐L1 and tumor mutational burden in 11,348 patients

Cancer Medicine, 2018
Microsatellite instability (MSI) testing identifies patients who may benefit from immune checkpoint inhibitors. We developed an MSI assay that uses data from a commercially available next‐generation sequencing (NGS) panel to determine MSI status.
A. Vanderwalde, D. Spetzler, N. Xiao, Z. Gatalica, J. Marshall   +4 more
semanticscholar   +1 more source

Microsatellite Instability and Colorectal Cancer

Archives of Pathology & Laboratory Medicine, 2011
Context.—About 15% of colorectal cancers are characterized by genomic microsatellite instability, and of these, about 1 in 5 (2%–4% overall) are due to Lynch syndrome, a dominantly inherited condition predisposing the patient to cancers of multiple organ systems, including the gastrointestinal tract.
Wade S. Samowitz, Katherine B. Geiersbach   +1 more
openaire   +2 more sources

Metabolic enrichment through functional gene rules [PDF]

arXiv, 2017
It is well known that tumors originating from the same tissue have different prognosis and sensitivity to treatments. Over the last decade, cancer genomics consortia like the Cancer Genome Atlas (TCGA) have been generating thousands of cross-sectional data, for thousands of human primary tumors originated from various tissues.
arxiv  

Prevalence of established and emerging biomarkers of immune checkpoint inhibitor response in advanced hepatocellular carcinoma. [PDF]

, 2019
The clinical deployment of immune checkpoint inhibitors (ICIs) has created a tandem drive for the identification of biomarkers linked to benefit. Comprehensive genomic profiling was performed to evaluate the frequency of genomic biomarkers of ICI ...
Ali, Siraj M, Ang, Celina, Fabrizio, David, Goodman, Aaron, Klempner, Samuel J, Kurzrock, Razelle, Madison, Russell, Millis, Sherri Z, Ross, Jeffrey S, Severson, Eric A, Suh, James   +10 more
core   +1 more source

Association between family history and mismatch repair in colorectal cancer [PDF]

, 2005
BACKGROUND AND AIMS: Germline mutations in mismatch repair (MMR) genes cause a greatly increased risk of cancer of the gastrointestinal and female reproductive tracts (hereditary non-polyposis colorectal cancer (HNPCC)).
Bell, S.M., Bishop, D.T., Cawkwell, L., Coggins, R.P., Crockford, G.P., Finan, P.J., Quirke, P.   +6 more
core   +2 more sources

Association of Primary Resistance to Immune Checkpoint Inhibitors in Metastatic Colorectal Cancer With Misdiagnosis of Microsatellite Instability or Mismatch Repair Deficiency Status

JAMA Oncology, 2019
Importance Primary resistance to immune checkpoint inhibitors is observed in 10% to 40% of patients with metastatic colorectal cancer (mCRC) displaying microsatellite instability (MSI) or defective mismatch repair (dMMR).
R. Cohen, E. Hain, O. Buhard, Agathe Guilloux, A. Bardier, R. Kaci, P. Bertheau, F. Renaud, F. Bibeau, J. Fléjou, T. André, M. Svrcek, A. Duval   +12 more
semanticscholar   +1 more source

Pan‐cancer analysis shapes the understanding of cancer biology and medicine

Cancer Communications, EarlyView.
Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen, Yuanyuan Lan, Jiansheng Zou, Ruilin Chen, Can Hu, Yahan Tong, Chen Zhang, Jingyue Chen, Yuanmei Wang, Run Zhou, Weiwei He, Tianyu Lu, Fred Dubee, Dragomirka Jovic, Wei Dong, Qingqing Gao, Man Ma, Youyong Lu, Yu Xue, Xiangdong Cheng, Yixue Li, Huanming Yang   +21 more
wiley   +1 more source

Validation of Microsatellite Instability Detection Using a Comprehensive Plasma-Based Genotyping Panel

Clinical Cancer Research, 2019
Purpose: To analytically and clinically validate microsatellite instability (MSI) detection using cell-free DNA (cfDNA) sequencing. Experimental Design: Pan-cancer MSI detection using Guardant360 was analytically validated according to established ...
J. Willis, M. Lefterova, Alexander Artyomenko, P. Kasi, Y. Nakamura, K. Mody, D. Catenacci, M. Fakih, Catalin C. Barbacioru, J. Zhao, Marcin Sikora, Stephen R. Fairclough, Hyuk Lee, Kyoung-Mee Kim, S. Kim, Jinchul Kim, Danielle Gavino, M. Benavides, N. Peled, Timmy Nguyen, M. Cusnir, R. Eskander, G. Azzi, T. Yoshino, K. Banks, V. Raymond, R. Lanman, Darya I. Chudova, Amirali Talasaz, S. Kopetz, Jeeyun Lee, J. Odegaard   +31 more
semanticscholar   +1 more source

Microsatellite Instability in Malignant Melanomas

Acta Dermato-Venereologica, 2001
Microsatellite instability (MSI) is caused by deficient DNA mismatch repair, and results in a "mutator" phenotype. Recent studies have produced contradictory results about the frequency and significance of MSI in malignant melanomas. In this study, we therefore determined the time of onset and relative frequency of MSI during the progression of ...
Michael Landthaler, Thomas Vogt, Maximilian M. Kroiss, Jürgen Schlegel, Wilhelm Stolz   +4 more
openaire   +4 more sources

Clinicopathological Characteristics of Colorectal Cancer with Family History: an Evaluation of Family History as a Predictive Factor for Microsatellite Instability [PDF]

, 2007
To determine whether family history of cancer may be a risk factor for the mutator phenotype in colorectal cancer, we recruited 143 consecutive colorectal cancer patients with a family history of accompanying cancers not meeting the Amsterdam criteria ...
Abdel-Rahman, Boland, Bradshaw, Bulow, Chang Sik Yu, Charbonnier, Church, Esteller, Hee Cheol Kim, Helm, In Ja Park, Ionov, Jin Cheon Kim, Johns, Kim, Lin, Lindor, McGrath, Moslein, Park, Pedroni, Peltomaki, Piñol, Samowitz, Se Jin Jang, Shia, Slattery, Soravia, Thibodeau, Umar, Vasen, Wang, Winawer, Yong Sik Yoon   +33 more
core   +2 more sources