Durable Disease Control With Nivolumab in Malignant Epithelioid Angiomyolipoma: A Case Report
ABSTRACT Introduction Epithelioid angiomyolipoma is a subtype of perivascular epithelioid cell tumors that may exhibit malignant behavior. While mammalian target of rapamycin inhibitors are commonly used for systemic treatment, the efficacy of immune checkpoint inhibitors remains unclear.
Hiroki Shimoda +9 more
wiley +1 more source
Immune Checkpoint Inhibition as a Novel Strategy for Microsatellite Instability-High Duodenal Adenocarcinoma: A Report of Three Cases. [PDF]
Shirabe K +8 more
europepmc +1 more source
Microbiome‐urothelium crosstalk in bladder cancer: From dysbiosis to clinical translation
This review elucidates the critical crosstalk between the urobiome and bladder cancer (BCa), mapping the landscape from ecological dysbiosis to clinical translation. We synthesize emerging evidence on microbial signatures that distinguish BCa patients, exploring key carcinogenic mechanisms including chronic inflammation, genotoxicity, and the gut ...
Haoxiang Xu +14 more
wiley +1 more source
Evaluating MRI response criteria in microsatellite instability-high rectal cancer treated with immune checkpoint inhibitors. [PDF]
Vanderbecq Q +6 more
europepmc +1 more source
Schematic of the study design. In this study, we developed a comprehensive unfolded protein response (UPR) gene signature and applied it to systematically characterize the UPR landscape across multiple cancer types. By integrating bulk and single‐cell transcriptomic data, we revealed substantial inter‐ and intra‐tumoral heterogeneity in UPR activity ...
Xinyu Yang +8 more
wiley +1 more source
Prediction of Microsatellite Instability in Colorectal Cancer Using Two Internally Validated Radiomic Models. [PDF]
Galluzzo A +11 more
europepmc +1 more source
ABSTRACT Hepatocellular carcinoma (HCC) represents a significant global health issue, with the PD‐1/PD‐L1 axis serving a pivotal target for immunotherapy in this malignancy. However, a comprehensive bibliometric analysis of PD‐1/PD‐L1 research in HCC is lacking.
Xingyu Zhu +4 more
wiley +1 more source
Ensemble learning for predicting microsatellite instability in colorectal cancer using pretreatment colonoscopy images and clinical data. [PDF]
You J +6 more
europepmc +1 more source
Patients with genetic variants that increase skin cancer risk are recommended to undergo regular dermatology screenings per National Comprehensive Cancer Network guidelines, but compliance is uncertain. In a retrospective study of 230 patients with such variants, compliance with screening visits significantly improved after visiting a Hereditary Cancer
Stephen J. Gadomski +4 more
wiley +1 more source
A two-stage deep learning prediction system for colon cancer microsatellite instability status using CT images. [PDF]
Cui S, Xiong X, Yang X, He J, Shen T.
europepmc +1 more source

