Results 161 to 170 of about 124,795 (370)

An Excellent Clinical and Radiological Response Pattern to Pembrolizumab in a Patient With Metastatic Adrenocortical Carcinoma and Lynch Syndrome

IJU Case Reports, EarlyView.
ABSTRACT Introduction The prognosis of unresectable metastatic adrenocortical carcinoma is very poor. We report a case of Lynch syndrome accompanying metastatic adrenocortical carcinoma treated with pembrolizumab. Case Presentation A 73‐year‐old woman was diagnosed with left adrenocortical carcinoma and multiple lung, liver, and lymph node metastases ...
Yuki Shimozawa, Yosuke Yasuda, Emiko Sugawara, Ryosuke Oki, Kosuke Takemura, Tetsuya Urasaki, Ryo Fujiwara, Noboru Numao, Junji Yonese, Takeshi Yuasa   +9 more
wiley   +1 more source

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas [PDF]

, 1998
Manel Esteller, Ross L. Levine, Stephen B. Baylin, Lora H. Ellenson, James G. Herman   +4 more
openalex   +1 more source

Molecular subtyping and precision therapy for esophageal cancer

Interdisciplinary Medicine, EarlyView.
The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze‐Xian Liu, Shegan Gao   +5 more
wiley   +1 more source

Colorectal cancer in a 13‐year‐old with constitutional mismatch repair deficiency and MUTYH heterozygosity

JPGN Reports, EarlyView.
Abstract Constitutional mismatch repair deficiency (CMMRD) is a rare hereditary cancer syndrome resulting from biallelic mutations in DNA mismatch repair (MMR) genes that lead to early‐onset cancers in children, including lymphoma and colorectal cancer (CRC).
Chloe J. Cohan, Caroline Chinchilla Putzeys, Brianna Pruniski, Paul Tran   +3 more
wiley   +1 more source

Microsatellite Instability in Adenomas as a Marker for Hereditary Nonpolyposis Colorectal Cancer [PDF]

, 1999
Anu Loukola, Reijo Salovaara, Paula Kristo, Anu‐Liisa Moisio, Helena Kääriäinen, Heikki Ahtola, Matti Eskelinen, N Härkönen, Risto Julkunen, Eero Kangas, Seppo Ojala, Jukka Tulikoura, Erkki Valkamo, Heikki Järvinen, Jukka‐Pekka Mecklin, Albert de la Chapelle, Lauri A. Aaltonen   +16 more
openalex   +1 more source

Phase I/II Trial of Perioperative Avelumab in Combination With Chemoradiation in the Treatment of Stage II/III Resectable Esophageal and Gastroesophageal Junction Cancer

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Standard treatment of patients with stage II/III esophageal or gastroesophageal junction (E/GEJ) cancer involves neoadjuvant chemoradiation (nCRT), resection, and immunotherapy. Our trial evaluated the addition of perioperative avelumab to standard treatments.
Nataliya V. Uboha, Mustafa M. Basree, Jens C. Eickhoff, Dustin A. Deming, Kristina Matkowskyj, James Maloney, Daniel McCarthy, Malcolm DeCamp, Noelle LoConte, Philip B. Emmerich, Sean Kraus, Monica A. Patel, Jeremy D. Kratz, Sam J. Lubner, Newton Hurst, Michael F. Bassetti   +15 more
wiley   +1 more source

CIMIL-CRC: a clinically-informed multiple instance learning framework for patient-level colorectal cancer molecular subtypes classification from H\&E stained images [PDF]

arXiv
Treatment approaches for colorectal cancer (CRC) are highly dependent on the molecular subtype, as immunotherapy has shown efficacy in cases with microsatellite instability (MSI) but is ineffective for the microsatellite stable (MSS) subtype. There is promising potential in utilizing deep neural networks (DNNs) to automate the differentiation of CRC ...
arxiv  

Microsatellite instability—a useful diagnostic tool to select patients at high risk for hereditary non-polyposis colorectal cancer: a study in different groups of patients with colorectal cancer [PDF]

, 1999
C. Lamberti, Roland Kruse, Corina Ruelfs, Reiner Caspari, Y Wang, Matthias Jungck, Micaela Mathiak, Hamid Reza Hosseiny Malayeri, Waltraut Friedl, Tilman Sauerbruch, Peter Propping   +10 more
openalex   +1 more source

Trends in Immunotherapy (IO) Use and Survival Among Patients With High‐Incidence Stage IV Cancers Across the United States

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives IO has transformed cancer management, but its adoption in advanced cancer patients varies by tumor type. With more Stage IV patients undergoing surgery, understanding site‐specific outcomes in these challenging patients is essential.
Samantha C. Warwar, Lauren M. Janczewski, Gladys M. Rodriguez, Jeffrey D. Wayne, David J. Bentrem   +4 more
wiley   +1 more source

Microsatellite Instability and Mutation of DNA Mismatch Repair Genes in Gliomas [PDF]

, 1998
Suet Yi Leung, Tsun Leung Chan, Lap Ping Chung, Annie S Y Chan, Yiu Wah Fan, Kwan Ngai Hung, Wai Kay Kwong, Judy W.C. Ho, Siu Tsan Yuen   +8 more
openalex   +1 more source