Results 171 to 180 of about 859,289 (399)

Microsatellite Instability: Diagnosis, Heterogeneity, Discordance, and Clinical Impact in Colorectal Cancer

Cancers, 2019
Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II colorectal cancer (CRC) and has become an indispensable test in metastatic tumors due ...
C. Evrard, G. Tachon, V. Randrian, L. Karayan‐Tapon, D. Tougeron   +4 more
semanticscholar   +1 more source

High prevalence of NTRK fusions in sporadic dMMR/MSI mCRC RAS/RAF wild-type: an opportunity for a post-immune checkpoint inhibitors progression rescue strategy

ESMO Gastrointestinal Oncology
Background: Currently, mismatch repair deficient/microsatellite instable (dMMR/MSI) status constitutes a validated predictive marker of response to immune checkpoint inhibitors (ICIs) in patients with metastatic colorectal cancer (mCRC).
M. Svrcek, A. Cayre, T. Samaille, R. Colle, L. Mas, P. Bourgoin, E. Guillerm, R. Cohen, F. Penault-Llorca, T. André, N. Radosevic-Robin   +10 more
doaj  

Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT) [PDF]

, 2011
The purpose of this study was to analyze the detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT). Data for a total of 492 patients who had undergone both PET/CT
A Katagiri, B Levin, BR Weston, CD Johnson, CG Fraser, D Ravizza, D Thorwarth, DF Halpenny, Eisuke Kaji, EM Kamel, EM Rohren, F Gutman, FA Sinicrope, H Pohl, Hideyuki Suzuki, J Czernin, JP Drenth, Jun Kato, Kazuhide Yamamoto, Keisuke Hori, KS Tagore, MB Tessem, MC Kouwen van, Mitsuhiro Akita, O Israel, PL Kei, R Meza, R Minamimoto, R Tatlidil, Reiji Higashi, S Friedland, S Halligan, S Kudo, S Kudo, S Tsuda, S Yasuda, Sakiko Hiraoka, Sakuma Takahashi, Shunsuke Saito, SS Shim, TF Imperiale, Tomoko Hirakawa, Toshio Uraoka, WS Samowitz, Y Zhao, Yoshihiro Okumura   +45 more
core   +1 more source

Pembrolizumab in Microsatellite Instability High or Mismatch Repair Deficient Cancers: Updated Analysis from the Phase 2 KEYNOTE-158 Study.

Annals of Oncology, 2022
M. Maio, P. Ascierto, L. Manzyuk, D. Motola-Kuba, N. Penel, P. Cassier, G. Bariani, A. de Jesus Acosta, T. Doi, F. Longo, W. Miller, D. Oh, M. Gottfried, L. Xu, F. Jin, K. Norwood, A. Marabelle   +16 more
semanticscholar   +1 more source

Microsatellite Instability as a Biomarker for PD-1 Blockade

Clinical Cancer Research, 2016
Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the New England Journal of Medicine, report significant responses of cancers with microsatellite instability (MSI) to anti–PD-1 inhibitors in patients who failed ...
J. Dudley, Ming-Tseh Lin, D. Le, J. Eshleman   +3 more
semanticscholar   +1 more source

Microsatellite instability in colorectal cancer

British Journal of Surgery, 2006
Abstract Background Microsatellite instability (MSI) causes hereditary non-polyposis colorectal cancer (HNPCC), and occurs in about 15 per cent of sporadic colorectal cancers. Although the basic mechanisms are not clear, there is increased understanding of the clinicopathological consequences of MSI.
Hartwig Kørner, Håvard Søiland, Emiel A. M. Janssen, Kjetil Søreide, Jan P. A. Baak, Jan P. A. Baak, Jan P. A. Baak   +6 more
openaire   +3 more sources

Endometrial cancer and microsatellite instability status

Open Medicine, 2014
Microsatellite instability (MSI) is an important factor in the development of various cancers as an identifier of a defective DNA mismatch repair system.
Kanopiene Daiva, Vidugiriene Jolanta, Povilas Valuckas Konstantinas, Smailyte Giedre, Uleckiene Saule, Bacher Jeff   +5 more
doaj   +1 more source

Colorectal cancer carcinogenesis: a review of mechanisms

Cancer Biology & Medicine, 2016
Colorectal cancer (CRC) is the second most common cancer in women and the third most common in men globally. CRC arises from one or a combination of chromosomal instability, CpG island methylator phenotype, and microsatellite instability.
Kanwal Tariq, Kulsoom Ghias
doaj   +1 more source

Microsatellite instability and defects in mismatch repair proteins: a new aetiology for Sertoli cell‐only syndrome [PDF]

, 2017
Microsatellite instability is characteristic of certain types of cancer, and is present in rodents lacking specific DNA mismatch repair proteins. These azoospermic mice exhibit spermatogenic defects similar to some human testicular failure patients ...
Casella, R., Kim, E., Lamb, D.J., Lipshultz, L.I., Lévy, N., Maduro, M.R., Niederberger, C.   +6 more
core  

Meta‐analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer

British Journal of Surgery, 2018
Several associations between microsatellite instability (MSI) and other clinicopathological factors have been reported in gastric cancer, but the results have been ambiguous.
K. Polom, K. Polom, L. Marano, D. Marrelli, R. Luca, G. Roviello, V. Savelli, P. Tan, F. Roviello   +8 more
semanticscholar   +1 more source