Results 171 to 180 of about 50,169 (235)

Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu, Rou Xue, Xiangwen Luo, Jiangnan Liao, Zongbo Zhang, Jinhai Deng, Teng Liu, Xin Li, Zhe‐Sheng Chen, Mingzhu Yin   +9 more
wiley   +1 more source

EMQN best practice guidelines for analysis and reporting of microsatellite instability in solid tumours. [PDF]

Eur J Hum Genet
Gallon R, McCormick L, Saetta A, Albuquerque C, Butler S, Cranston T, Field J, McAnulty C, Silva P, Cheetham M, Sheils K, Burghel GJ.   +11 more
europepmc   +1 more source

Early Cancer Detection: What's Going on and What's Next

MedComm, Volume 7, Issue 3, March 2026.
Multicancer early detection (MCED) platforms have emerged as a promising strategy for the safe and effective early detection of multiple cancer types, with the potential to reduce metastatic burden and improve clinical outcomes, particularly for aggressive malignancies that lack effective population‐level screening.
Emma Di Carlo
wiley   +1 more source

Evaluation of microsatellite instability patterns in mismatch repair deficiency: a retrospective analysis of 285 endometrial cancers. [PDF]

Front Immunol
Wang C, Feng M, Kou Y, Kuang W, Wang W, Liang D.   +5 more
europepmc   +1 more source

Clinical Application of Peripheral Blood Biomarkers for Solid Tumors

MedComm, Volume 7, Issue 3, March 2026.
Peripheral blood biomarkers provide a minimally invasive, dynamic, and potentially more accurate means to obtain a comprehensive tumor profile. Technologies for detecting them are advancing, and with the help of artificial intelligence, they are being used more and more often for cancer diagnosis, prognostic assessment, and therapeutic monitoring ...
Xinru Tu, Mengyan Tu, Junfen Xu
wiley   +1 more source

Detection of urothelial carcinoma in Lynch syndrome using microsatellite instability analysis of urine cell-free DNA. [PDF]

EBioMedicine
Hall R, Gallon R, Hayes C, Herrero-Belmonte P, Phelps R, Job D, Wake R, Ferrier M, Turner H, O'Donnell R, Nambiar A, Rai B, Martin R, McAnulty C, Santibanez-Koref M, Heer R, Jackson MS, Burn J.   +17 more
europepmc   +1 more source

Systematic Identification of Molecular Signatures Dictating Therapeutic Effects of Clinically First‐Line Chemotherapy Regimens for Human Gastric Cancer Patients Based on Organoid Model

MedComm, Volume 7, Issue 3, March 2026.
Chemotherapy is the mainstay in the treatment of advanced gastric cancer (GC); yet, GC showed diverse responses to first‐line chemotherapy regimens and the underlying molecular basis is still not clear. Here, we established a system that combined organoid‐based chemotherapy regimen screening and transcriptome‐based evaluation to identify underlying ...
Jingwei Yang, Shuyue Qi, Yuan Gao, Jiansen Lu, Lin Deng, Xinglong Wu, Yifei Zhao, Yun Liu, Yanpeng Ma, Jiagui Song, Lixiang Xue, Lu Wen, Wei Fu, Fuchou Tang, Xin Zhou   +14 more
wiley   +1 more source

Discordance between radiological and pathological response to neoadjuvant immunotherapy in mismatch repair-deficient/microsatellite instability-high colorectal cancer: a meta-analysis. [PDF]

Front Immunol
Xie Y, Liao L, Ding P, Jiang W.
europepmc   +1 more source

Safety and Efficacy of Lucitanib Plus Toripalimab in Advanced Solid Tumors Refractory to Standard Therapies: An Open‐Label, Multicenter, Phase II Study

MedComm, Volume 7, Issue 3, March 2026.
Lucitanib plus toripalimab showed manageable safety and encouraging antitumor activity in advanced solid tumors, particularly in PD‐1‐refractory nasopharyngeal carcinoma and recurrent endometrial carcinoma. Clinical responses were observed across subgroups regardless of prior immunotherapy.
Ting Zhou, Haishuang Sun, Gang Chen, Guoping Zhang, Jinsheng Wu, Shenhong Qu, Yaqian Han, Desheng Hu, Yang Ling, Yulong Zheng, Jian Liu, Lizhu Lin, Yongsheng Li, Jianji Pan, Yanyan Liu, Cuiying Wang, Guohong Fu, Jian Feng, Jianhua Shi, Huiming Cai, Meng Li, Fugen Li, Yinbin Wang, Li Zhang, Yunpeng Yang   +24 more
wiley   +1 more source