Results 51 to 60 of about 124,795 (370)

Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability

Gastroenterology Review, 2016
Introduction: Colorectal medullary carcinoma (MC) is a rare subtype of poorly differentiated adenocarcinoma (PDA) with unclear prognostic significance.
Miguel A. Gómez-Álvarez, Leonardo S. Lino-Silva, Rosa A. Salcedo-Hernández, Alejandro Padilla-Rosciano, Erika B. Ruiz-García, Horacio N. López-Basave, German Calderillo-Ruiz, José M. Aguilar-Romero, Jorge A. Domínguez-Rodríguez, Ángel Herrera-Gómez, Abelardo Meneses-García   +10 more
doaj   +1 more source

Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs

Journal of Veterinary Internal Medicine, 2022
Background Microsatellite instability (MSI) is a type of genomic instability caused by mismatch repair deficiency (dMMR) in tumors. Studies on dMMR/MSI are limited, and the relationship between dMMR and MSI is unknown in tumors of dogs.
Sakuya Inanaga, Masaya Igase, Yusuke Sakai, Kenji Hagimori, Hiroshi Sunahara, Hiro Horikirizono, Kazuhito Itamoto, Kenji Baba, Yoshiharu Ohsato, Takuya Mizuno   +9 more
doaj   +1 more source

An Escherichia coli effector protein promotes host mutation via depletion of DNA mismatch repair proteins. [PDF]

, 2013
Enteropathogenic Escherichia coli (EPEC) is an attaching and effacing (A/E) human pathogen that causes diarrhea during acute infection, and it can also sustain asymptomatic colonization. A/E E.
Donnenberg, Michael S., Maddocks, Oliver David Kenneth, Scanlon, Karen Mary   +2 more
core   +1 more source

Relationship between protein biomarkers of chemotherapy response and microsatellite status, tumor mutational burden and PD-L1 expression in cancer patients. [PDF]

, 2020
Chemotherapy and checkpoint inhibitor immunotherapies are increasingly used in combinations. We determined associations between the presence of anti-PD-1/PD-L1 therapeutic biomarkers and protein markers of potential chemotherapy response.
Arguello, David, Barkauskas, Donald A, Gatalica, Zoran, Kurzrock, Razelle, Nikanjam, Mina, Swensen, Jeff   +5 more
core   +2 more sources

Development and validation of deep learning classifiers to detect Epstein-Barr virus and microsatellite instability status in gastric cancer: a retrospective multicentre cohort study [PDF]

, 2021
Background: Response to immunotherapy in gastric cancer is associated with microsatellite instability (or mismatch repair deficiency) and Epstein-Barr virus (EBV) positivity.
Alakus H., Allum W. H., Cheong J. -H., Cunningham D., d'Ignazio A., Dislich B., Ebert M. P., Gaisa N. T., Grabsch H. I., Grosser B., Hayden J. D., Heij L. R., Huss R., Irvine A. J., Jager D., Kather J. N., Keller G., Kim H., Kim Y. -W., Kohlruss M., Kook M. -C., Langer R., Langley R. E., Luedde T., Muti H. S., Nankivell M. G., Oshima T., Pearson A. T., Quaas A., Quirke P., Roviello F., Tan X., Trautwein C., West N. P., Yoshikawa T.   +34 more
core   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Microsatellite instability in endometrial polyps [PDF]

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010
To investigate the prevalence of microsatellite instability (MSI) in endometrial polyps and to evaluate whether there are clinical and histopathological parameters associated with this kind of instability.Between September 2008 and April 2009, endometrial polyps were collected from 109 patients. MSI was evaluated using the NCI recommended markers BAT25,
Rosângela Vieira de Andrade, Érica Carvalho Caldas, Nathan R. Wall, Salete da Silva Rios, Khaled Bahjri, Florêncio Figueiredo, Florêncio Figueiredo, Larissa Cavalcante, Rinaldo Wellerson Pereira   +8 more
openaire   +2 more sources

A molecular portrait of microsatellite instability across multiple cancers

Nature Communications, 2017
Some cancers with DNA mismatch repair deficiency display microsatellite instability. Here the authors analyse twenty three cancer types at the exome and whole-genome level, and identify loci with recurrent microsatellite instability that could be used to
Isidro Cortes-Ciriano, Sejoon Lee, Woong-Yang Park, Tae-Min Kim, Peter J. Park   +4 more
doaj   +1 more source

XDEEP-MSI: Explainable Bias-Rejecting Microsatellite Instability Deep Learning System In Colorectal Cancer [PDF]

arXiv, 2021
We present a system for the prediction of microsatellite instability (MSI) from H&E images of colorectal cancer using deep learning (DL) techniques customized for tissue microarrays (TMAs). The system incorporates an end-to-end image preprocessing module that produces tiles at multiple magnifications in the regions of interest as guided by a tissue ...
arxiv  

Genomic instability in human cancer: molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition [PDF]

, 2015
Genomic instability can initiate cancer, augment progression, and influence the overall prognosis of the affected patient. Genomic instability arises from many different pathways, such as telomere damage, centrosome amplification, epigenetic ...
Amedei, Amedeo, Amin, Amr, Aquilano, Katia, Ashraf, S. Salman, Azmi, Asfar S., Bhakta, Dipita, Bilsland, Alan, Boosani, Chandra S., Chen, Helen, Chen, Sophie, Ciriolo, Maria Rosa, Collins, Andrew R., Connell, Marisa, Damia, Giovanna, Dasgupta, Santanu, Ferguson, Lynnette R., Fujii, Hiromasa, Guha, Gunjan, Halicka, Dorota, Helferich, William G., Honoki, Kanya, Keith, W. Nicol, Malhotra, Meenakshi, Maxwell, Christopher A., Meeker, Alan K., Mohammed, Sulma I., Niccolai, Elena, Parslow, Virginia R., Prakash, Satya, Rezazadeh, Sarallah, Shackelford, Rodney E., Sidransky, David, Tran, Phuoc T., Yang, Eddy S., Yang, Xujuan   +34 more
core   +1 more source