Results 51 to 60 of about 55,423 (289)

Systemic Therapy for Microsatellite Instability Small Bowel Adenocarcinoma With Mesenteric Vascular Embolism as Initial Symptom: A Case Report

Frontiers in Medicine, 2021
Background: Small bowel adenocarcinoma are relatively rare tumors of the digestive system. Due to the lack of specific screening methods, patients are often diagnosed at an advanced stage.
Zhongyi Dong, Xiang Xia, Zizhen Zhang
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Conversion surgery for microsatellite instability-high gastric cancer with a complete pathological response to pembrolizumab: a case report [PDF]

, 2022
Yoshifumi Hidaka, Takaaki Arigami, Yusaku Osako, Ryosuke Desaki, Masahiro Hamanoue, Sonshin Takao, Mari Kirishima, Takao Ohtsuka   +7 more
openalex   +1 more source

Microsatellite instability in endometrial polyps [PDF]

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010
To investigate the prevalence of microsatellite instability (MSI) in endometrial polyps and to evaluate whether there are clinical and histopathological parameters associated with this kind of instability.Between September 2008 and April 2009, endometrial polyps were collected from 109 patients. MSI was evaluated using the NCI recommended markers BAT25,
Salete S, Rios, Rosângela V, Andrade, Rinaldo W, Pereira, Nathan R, Wall, Khaled, Bahjri, Érica, Caldas, Larissa, Cavalcante, Florêncio, Figueiredo   +7 more
openaire   +2 more sources

Prognostic and Predictive Role of Lymph Node Count in Stage II Colon Cancer: A Retrospective Analysis of a Japanese Nationwide Cohort

Annals of Gastroenterological Surgery, EarlyView.
This study analyzed over 3500 patients with stage II colon cancer treated with D3 lymphadenectomy, to reassess the prognostic value of number of harvested lymph node and their role in predicting benefit from adjuvant chemotherapy using a Japanese nationwide cohort.
Kozo Kataoka, Akira Ouchi, Kanae Takahashi, Kazuma Ito, Manabu Shiozawa, Kenta Iguchi, Takashi Akiyoshi, Takefumi Yoshida, Masataka Ikeda, Eiji Shinto, Yasuyuki Takamizawa, Yoichi Ajioka, Hirotoshi Kobayashi, Yukihide Kanemitsu   +13 more
wiley   +1 more source

Detection of mutator phenotype in Brazilian patients with acute and chronic myeloid leukemia

Genetics and Molecular Biology, 2004
The multisteps of tumorigenesis involve the classic chromosomal instability and the mutator phenotype pathways featured by a predisposition to acquire mutations in tumor suppressor genes and oncogenes.
Flávio Monteiro Ayres, Euza Guimarães Momotuk, Celso da Cunha Bastos, Aparecido Divino da Cruz   +3 more
doaj   +1 more source

Prognostic Impact of Histologic Subtypes in Mismatch Repair‐Deficient/Microsatellite Instability‐High Colorectal Cancer: A Single‐Center Retrospective Study of 1127 Stage 0–IV Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Deficient mismatch repair/microsatellite instability‐High (dMMR/MSI‐H) colorectal cancer (CRC) generally confers a favorable survival yet is paradoxically enriched for poorly differentiated (Por) histology, which is linked to aggressive behavior.
Tomoyuki Momma, Hirokazu Okayama, Sohei Hayashishita, Hiroya Suzuki, Masanori Katagata, Takuro Matsumoto, Daisuke Ujiie, Shun Chida, Wataru Sakamoto, Koji Kono   +9 more
wiley   +1 more source

Molecular markers as predictors of response to perioperative chemotherapy in locally advanced gastric cancer

Успехи молекулярной онкологии, 2023
Introduction. Perioperative FLOT chemotherapy has improved prognosis in patients with locally advanced resectable gastric cancer (GC). However, in 80 % of cases, the tumor is resistant to the therapy, resulting in unnecessary toxicity and delayed ...
K. A. Oganyan, A. A. Musaelyan, S. V. Lapin, T. V. Kupenskaya, A. A. Sveсhkova, M. A. Belyaev, A. A. Zakharenko, S. V. Orlov   +7 more
doaj   +1 more source

Predicting Postresection Colorectal Liver Metastases Recurrence Using Advanced Graph Neural Networks with Explainability and Causal Inference

Advanced Intelligent Systems, EarlyView.
This study introduces a framework that combines graph neural networks with causal inference to forecast recurrence and uncover the clinical and pathological factors driving it. It further provides interpretability, validates risk factors via counterfactual and interventional analyses, and offers evidence‐based insights for treatment planning ...
Jubair Ahmed, Md. Abdur Rahman, Mohaimenul Azam Khan Raiaan, Sami Azam   +3 more
wiley   +1 more source

Intrinsic structural variation of the complex microsatellite marker MYCL1 in Finnish and Somali populations and its relevance to gastrointestinal tumors

Genetics and Molecular Biology, 2006
The structurally complex MYCL1 microsatellite marker is often used to determine microsatellite instability in colorectal cancers but the allelic variation of this marker has remained largely uncharacterized in both populations and in cancers.
Hanna Vauhkonen, Antti Sajantila
doaj   +1 more source