Microhaplotype Methods Enable Relationship Inference in a Bottlenecked Mammalian Species
Animal Conservation, EarlyView.Northern elephant seals (Mirounga angustirostris) are among the most genetically depauperate mammals in the world. A near‐total population bottleneck in the 19th century, coupled with the breeding system of extreme polygyny, has challenged efforts to estimate individual reproductive success with genetic methods.
Keith M. Hernandez +6 more
wiley +1 more source
Development and Validation of Tetranucleotide Repeat Microsatellite Markers at the Whole-Genome Level in the Yangtze Finless Porpoise [PDF]
Meng‐Ting Tang +10 more
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Robust Preimplantation Genetic Testing of Huntington Disease by Combined Triplet-Primed PCR Analysis of the HTT CAG Repeat and Multi-Microsatellite Haplotyping [PDF]
, 2019 Mingjue Zhao +6 more
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Epigenome editing of microsatellite repeats defines tumor-specific enhancer functions and dependencies. [PDF]
Genes Dev, 2018 Boulay G +6 more
europepmc +1 more source
Inheritance and diversity of simple sequence repeat (SSR) microsatellite markers in various families of Picea abies [PDF]
, 2003 Reza Yazdani +4 more
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Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Fragile X syndrome: genetic localisation by linkage mapping of two microsatellite repeats FRAXAC1 and FRAXAC2 which immediately flank the fragile site. [PDF]
, 1991 Robert I. Richards +8 more
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Clinical Genetics, EarlyView.The frequency and severity of congenital heart disease vary extensively in individuals with 22q11.22–23 distal deletions. Reduced gene dosage particularly within the low copy repeat (LCR22) D–E region including MAPK1 and HIC2 conveys risk for these defects.
Tanner J. Nelson +22 more
wiley +1 more source
An A13 Repeat within the 3′-Untranslated Region of Epidermal Growth Factor Receptor (EGFR) Is Frequently Mutated in Microsatellite Instability Colon Cancers and Is Associated with Increased EGFR Expression [PDF]
, 2009 Ziqiang Yuan +15 more
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