Results 121 to 130 of about 28,249 (264)
Integrative Zoology, EarlyView.Basalt‐dwelling blind mole rats maintain lower body temperatures, show greater post‐digging thermal increases, and dig more efficiently than those from rendzina soils. Although metabolic rates and bite force did not differ between populations, these thermal and physiological shifts align with the greater mechanical resistance and seasonal hypoxia of ...
Matěj Lövy +6 more
wiley +1 more source
Genomic Assessment of Reintroduced African Wild Dogs Informs Conservation Translocations
Animal Conservation, EarlyView.Few reintroduction and translocation programs incorporate genomic assessments into management planning, despite ongoing debate over how founder individuals should be selected. Here, we assess the genomic composition of reintroduced African wild dog (Lycaon pictus) populations in private reserves in South Africa, comparing them with a free‐roaming ...
Michou Weimar +4 more
wiley +1 more source
ANZ Journal of Surgery, EarlyView.ABSTRACT Background Early onset colorectal cancer (EoCRC), commonly defined as colorectal cancer diagnosed in people under 50 years of age, is increasing in incidence in Australia and New Zealand. The underlying cause of this remains unclear, despite its growing public health importance.
Tiffany J. Cherry +2 more
wiley +1 more source
Chromosomal distribution of microsatellite repeats in Amazon cichlids genome (Pisces, Cichlidae). [PDF]
Comp Cytogenet, 2015 Schneider CH +5 more
europepmc +1 more source
Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy
Acta Ophthalmologica, EarlyView.Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki +10 more
wiley +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer +5 more
wiley +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Targeting KRAS for cancer therapy
British Journal of Pharmacology, EarlyView.In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia +4 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam +4 more
wiley +1 more source
MICdb3.0: a comprehensive resource of microsatellite repeats from prokaryotic genomes. [PDF]
Database (Oxford), 2014 Mudunuri SB, Patnana S, Nagarajaram HA.
europepmc +1 more source