Results 51 to 60 of about 197,824 (292)

RNA biology of disease-associated microsatellite repeat expansions [PDF]

Acta Neuropathologica Communications, 2017
Microsatellites, or simple tandem repeat sequences, occur naturally in the human genome and have important roles in genome evolution and function. However, the expansion of microsatellites is associated with over two dozen neurological diseases. A common denominator among the majority of these disorders is the expression of expanded tandem repeat ...
Kushal J. Rohilla, Keith T. Gagnon
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

AT-rich microsatellite loci development for Fejervarya multistriata by Illumina HiSeq sequencing

Acta Herpetologica, 2019
In our study, a total of 2561 sequences that contained microsatellite loci were found potentially to be used for primer design. Furthermore, Illumina HiSeq sequencing technology identified trinucleotide repeats and AT-rich repeats with the the highest ...
Yan-Mei Wang, Jing-Yi Chen, Guo-Hua Ding, Zhi-Hua Lin   +3 more
doaj   +1 more source

Distribution of Di- to Hexa- microsatellite motifs in Anisogrammaanomala by number of repeats.

, 2013
Distribution of Di- to Hexa- microsatellite motifs in Anisogrammaanomala by number of repeats.
Megan F. Muehlbauer (490599), Thomas J. Molnar (490600), Clayton W. Leadbetter (490598), Bradley I. Hillman (466130), Guohong Cai (490597)   +4 more
core   +1 more source

Alu Repeats: A Source for the Genesis of Primate Microsatellites

Genomics, 1995
As a result of their abundance, relatively uniform distribution, and high degree of polymorphism, microsatellites and minisatellites have become valuable tools in genetic mapping, forensic identity testing, and population studies. In recent years, a number of microsatellite repeats have been found to be associated with Alu interspersed repeated DNA ...
S S, Arcot, Z, Wang, J L, Weber, P L, Deininger, M A, Batzer   +4 more
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Clinicopathologic correlation of microsatellite instability with tri/tetranucleotide repeats in sporadic epithelial ovarian cancer [PDF]

, 2005
To determine how microsatellite instability (MSI) is related to clinicopathologic characteristics of epithelial ovarian cancer, we investigated MSI frequency on mono-, di-, tri-, and tetranucleotide repeats in 52 sporadic ovarian cancers.
Nakai, Hidekatsu, Hoshiai, Hiroshi, Ueda, Haruhiko, Watanabe, Yoh   +3 more
core   +1 more source

EST-SSR Marker Development from Cannabis Sequence Data: A Resource for Genetic Diversity and Breeding Research

ISPEC Journal of Agricultural Sciences
Cannabis (Cannabis sativa L.) is a valuable crop utilized for the production of food, fiber, oils, and psychotropic compounds. DNA molecular markers are essential in cannabis breeding research, enabling the identification of genes associated with ...
Ayşe Gül İNCE, Mehmet KARACA
doaj   +1 more source

FISH mapping and molecular organization of the major repetitive sequences of tomato [PDF]

, 2008
This paper presents a bird's-eye view of the major repeats and chromatin types of tomato. Using fluorescence in-situ hybridization (FISH) with Cot-1, Cot-10 and Cot-100 DNA as probes we mapped repetitive sequences of different complexity on pachytene ...
Chang, S.B., Jong, J.H.S.G.M., de, Meznikova, M., Datema, E., Vugt, J., van, Jacobsen, E., Yang, T.J., Kuipers, A., Szinay, D., Klein Lankhorst, R.M., Vosman, B.   +10 more
core   +1 more source

Analysis of microsatellite polymorphism in inbred knockout mice. [PDF]

PLoS ONE, 2012
Previously, we found that the genotype of 42 out of 198 mouse microsatellite loci, which are distributed among all chromosomes except the Y chromosome, changed from monomorphism to polymorphism (CMP) in a genetically modified inbred mouse strain. In this
Baofen Zuo, Xiaoyan Du, Jing Zhao, Huixin Yang, Chao Wang, Yanhua Wu, Jing Lu, Ying Wang, Zhenwen Chen   +8 more
doaj   +1 more source