Results 121 to 130 of about 4,192,823 (318)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Holographic description of Kerr-Bolt-AdS-dS Spacetimes

, 2011
We show that there exists a holographic 2D CFT description of a Kerr-Bolt-AdS-dS spacetime. We first consider the wave equation of a massless scalar field propagating in extremal Kerr-Bolt-AdS-dS spacetimes and find in the "near region", the wave ...
A.M. Ghezelbash, Amsel, B. Chen, Bardeen, Becker, Becker, Bredberg, Brown, Castro, Castro, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Cvetic, Dias, Dias, Fareghbal, Ghezelbash, Ghezelbash, Ghezelbash, Ghezelbash, Guica, Hartman, Hartman, Hartman, Krishnan, Li, Li, Lu, M.R. Setare, Matsuo, Setare, Son, V. Kamali, Wang, Wang   +41 more
core   +1 more source

Research progress on multi-scale damage of rock

Meitan kexue jishu
Rock damage and rupture is a multi-scale chain damage rupture process from microscopic to mesoscopic to macroscopic. It is essential to clarify the damage characteristics of rock at different scales and establish the quantitative relationships of multi ...
Fengzhen HE, Guichen LI, Jiaguang KAN, Xingliang XU, Xiaowei FENG, Yuantian SUN   +5 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

IDENTIFICATION OF MAXIMUM INACCURACY OF TOOLMAKERS MICROSCOPE

TECHNICAL SCIENCES AND TECHNOLOGIES, 2019
Urgency of the research. There are several types of measurement devices. Industrial practice needs simple, fast and cheap measurement system for inspection of produced parts. There is a need for system like toolmakers microscope. Target setting.
Kelemenová, Tatiana, Miroslav, Dovica
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Automated tuberculosis diagnosis: A hybrid approach using attention-residual U-Net segmentation with ensemble classification

Franklin Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a critical global health issue, underscoring the necessity of timely diagnosis and treatment.
Greeshma K., Vishnukumar S.
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Diversity of Fungi in the Traditional Slovak Cheese “Parenica”

Scientific Papers Animal Science and Biotechnologies, 2023
Fungi as a group are some of the most resilient spoilage microorganisms and are capable of overcoming the control strategies utilized by the food industry. Various fungal propagules are rapidly dispersed by water and air, survive under extreme conditions,
Miroslava Kačániová, Soňa Felsöciová, Peter Haščík, Ľudmila Nagyová, Elena Horská, Margarita Terentjeva, Simona Kunová   +6 more
doaj