Results 61 to 70 of about 1,972,851 (282)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Measuring the effects of ice thickness on resolution in single particle cryo-EM

Journal of Structural Biology: X, 2023
Ice thickness is a critical parameter in single particle cryo-EM – too thin ice can break during imaging or exclude the sample of interest, while ice that is too thick contributes to more inelastic scattering that precludes obtaining high resolution ...
Kasahun Neselu, Bing Wang, William J. Rice, Clinton S. Potter, Bridget Carragher, Eugene Y.D. Chua   +5 more
doaj   +1 more source

Four-dimensional ultrafast electron microscopy of phase transitions [PDF]

, 2006
Reported here is direct imaging (and diffraction) by using 4D ultrafast electron microscopy (UEM) with combined spatial and temporal resolutions. In the first phase of UEM, it was possible to obtain snapshot images by using timed, single-electron packets;
A. H. Zewail, Cavalleri, Ernst, Imada, J. Weissenrieder, Koethe, Li, M. S. Grinolds, Rice, V. A. Lobastov, Vasilescu, Wentzcovitch, Zewail   +12 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Comparison of atomic scale dynamics for the middle and late transition metal nanocatalysts

Nature Communications, 2018
The atomistic behaviour of nanocatalysts still remains largely unknown. Here, the authors reveal and explore reactions of nm-sized clusters of 14 technologically important metals in carbon nano test tubes using time-series imaging by atomically-resolved ...
Kecheng Cao, Thilo Zoberbier, Johannes Biskupek, Akos Botos, Robert L. McSweeney, Abdullah Kurtoglu, Craig T. Stoppiello, Alexander V. Markevich, Elena Besley, Thomas W. Chamberlain, Ute Kaiser, Andrei N. Khlobystov   +11 more
doaj   +1 more source

AgNP-PVP-meglumine antimoniate nanocomposite reduces Leishmania amazonensis infection in macrophages

BMC Microbiology, 2021
Background Leishmaniasis is an infectious disease caused by parasites of the genus Leishmania and presents different clinical manifestations. The adverse effects, immunosuppression and resistant strains associated with this disease necessitate the ...
Ana Patricia Cacua Gélvez, José Antonio Picanço Diniz Junior, Rebecca Thereza Silva Santa Brígida, Ana Paula Drummond Rodrigues   +3 more
doaj   +1 more source

Thermokinetic Study of Aluminum-Induced Crystallization of a-Si: The Effect of Al Layer Thickness

Nanomaterials, 2023
The effect of the aluminum layer on the kinetics and mechanism of aluminum-induced crystallization (AIC) of amorphous silicon (a-Si) in (Al/a-Si)n multilayered films was studied using a complex of in situ methods (simultaneous thermal analysis ...
Sergey M. Zharkov, Vladimir V. Yumashev, Evgeny T. Moiseenko, Roman R. Altunin, Leonid A. Solovyov, Mikhail N. Volochaev, Galina M. Zeer, Nataliya S. Nikolaeva, Oleg V. Belousov   +8 more
doaj   +1 more source

Single-crystal silver nanowires: Preparation and Surface-enhanced Raman Scattering (SERS) property

, 2011
Ordered Ag nanowire arrays with high aspect ratio and high density self-supporting Ag nanowire patterns were successfully prepared using potentiostatic electrodeposition within the confined nanochannels of a commercial porous anodic aluminium oxide (AAO)
alizadeh, Baoliang Sun, Chaney, Cheng, Drachev, Hu, Kim, Kong, Mardilovich, Moskovits, Mulvaney, Nikoobakht, Pan, Riveros, Shuxi Dai, Tian, Xiaohong Jiang, Yang, Yao, Zuliang Du   +19 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Probing electronic structure in berkelium and californium via an electron microscopy nanosampling approach

Nature Communications, 2021
The obtention and study of actinide elements is challenging due to various factors including their radioactivity and scarcity. Herein, the authors characterize the atomic and electronic structure of Am, Cm, Bk, and Cf compounds using a transmission ...
Alexander Müller, Gauthier J.-P. Deblonde, Peter Ercius, Steven E. Zeltmann, Rebecca J. Abergel, Andrew M. Minor   +5 more
doaj   +1 more source