Results 1 to 10 of about 50,037 (190)
Evaluation of Betulin Mutagenicity by Salmonella/Microsome Test [PDF]
Advanced Pharmaceutical Bulletin, 2016 Purpose: Betulin is a pentacyclic triterpene found in the outer barks of innumerous plants. This secondary metabolite is easily isolated from plants with the major interest in converting it to betulinic acid, which pharmacological properties were much ...
Edson Hideaki Yoshida +5 more
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Frontiers in Chemistry, 2019 In this study, the metabolic profiles of a new illicit drug AMB-FUBINACA were investigated using both human liver microsome and zebrafish models. Liquid chromatography Q Extractive HF Hybrid Quadrupole-Orbitrap mass spectrometry (LC-QE-HF-MS) was ...
Duo-qi Xu +5 more
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Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac [PDF]
MoleculesBackground: The aim of this study is to determine the impact of species and tissue differences on the glucuronidation of diclofenac in vitro. Method: Microsomes from different species (rat, monkey, mouse, dog, and human) and rat and human tissues (liver,
Eric Asare +5 more
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The Scientific World Journal, 2016 The present study aimed to investigate the in vitro mutagenic activity of Origanum majorana essential oil. The most abundant compounds identified by GC-MS were γ-terpinene (25.73%), α-terpinene (17.35%), terpinen-4-ol (17.24%), and sabinene (10.8 ...
Andrea dos Santos Dantas +8 more
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ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs. [PDF]
PLoS Pathogens, 2016 Stimulator of interferon genes (STING, also known as MITA, ERIS or MPYS) induces the activation of TBK1 kinase and IRF3 transcription factor, upon sensing of microbial DNAs. How IRF3 is recruited onto the STING signalosome remains unknown. We report here
Wei Chen +10 more
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Assessing in vitro stability of remdesivir (GS-5734) and conversion to GS-441524 in feline plasma and whole blood [PDF]
Veterinary QuarterlyFeline infectious peritonitis (FIP) is a potentially fatal coronavirus-driven disease of cats. Treatment with nucleoside analogue GS-441524 and or prodrug remdesivir (RDV) have produced remission in both experimentally induced and naturally occurring FIP,
Sally J. Coggins +5 more
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Microsome Isolation from Tissue
Bio-Protocol, 2014 This protocol details the extraction of microsomes from frozen tissue in order to further examine the protein-protein interactions occurring within the endoplasmic reticulum. This protocol was adapted from Abisambra et al.
Maria Bodero, Jose Abisambra
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A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions [PDF]
Scientific ReportsSolid transplant recipients are at increased risk for invasive aspergillosis. Tacrolimus and Voriconazole is one of the most frequently utilized treatments for those recipients with invasive fungal infections.
Yi-Chang Zhao +10 more
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Microbiology Spectrum, 2022 Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a recent study, a library screening strategy was developed in which an FDA-approved drug library was screened against ...
Shivani Gargvanshi, William G. Gutheil
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Frontiers in Pharmacology, 2022 Cytochrome 2C9 (CYP2C9), one of the most important drug metabolic enzymes in the human hepatic P450 superfamily, is required for the metabolism of 15% of clinical drugs.
Fang-Ling Zhao +13 more
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