Results 1 to 10 of about 22,884 (277)

Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac [PDF]

Molecules
Background: The aim of this study is to determine the impact of species and tissue differences on the glucuronidation of diclofenac in vitro. Method: Microsomes from different species (rat, monkey, mouse, dog, and human) and rat and human tissues (liver,
Eric Asare, Shalom Emmanuel, Ting Du, Huan Xie, Dong Liang, Song Gao   +5 more
doaj   +2 more sources

Assessing in vitro stability of remdesivir (GS-5734) and conversion to GS-441524 in feline plasma and whole blood [PDF]

Veterinary Quarterly
Feline infectious peritonitis (FIP) is a potentially fatal coronavirus-driven disease of cats. Treatment with nucleoside analogue GS-441524 and or prodrug remdesivir (RDV) have produced remission in both experimentally induced and naturally occurring FIP,
Sally J. Coggins, Benjamin Kimble, Richard Malik, Mary F. Thompson, Jacqueline M. Norris, Merran Govendir   +5 more
doaj   +2 more sources

Microsome Isolation from Tissue

Bio-Protocol, 2014
This protocol details the extraction of microsomes from frozen tissue in order to further examine the protein-protein interactions occurring within the endoplasmic reticulum. This protocol was adapted from Abisambra et al.
Maria Bodero, Jose Abisambra
doaj   +4 more sources

Library Screening for Synergistic Combinations of FDA-Approved Drugs and Metabolites with Vancomycin against VanA-Type Vancomycin-Resistant Enterococcus faecium

Microbiology Spectrum, 2022
Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a recent study, a library screening strategy was developed in which an FDA-approved drug library was screened against ...
Shivani Gargvanshi, William G. Gutheil
doaj   +1 more source

Identification and drug metabolic characterization of four new CYP2C9 variants CYP2C9*72-*75 in the Chinese Han population

Frontiers in Pharmacology, 2022
Cytochrome 2C9 (CYP2C9), one of the most important drug metabolic enzymes in the human hepatic P450 superfamily, is required for the metabolism of 15% of clinical drugs.
Fang-Ling Zhao, Fang-Ling Zhao, Qing Zhang, Shuang-Hu Wang, Yun Hong, Shan Zhou, Quan Zhou, Pei-Wu Geng, Qing-Feng Luo, Jie-Fu Yang, Hao Chen, Jian-Ping Cai, Da-Peng Dai, Da-Peng Dai   +13 more
doaj   +1 more source

Screening the NCI diversity set V for anti-MRSA activity: cefoxitin synergy and LC-MS/MS confirmation of folate/thymidine biosynthesis inhibition

Microbiology Spectrum, 2023
New antibacterial agents and agent combinations are urgently needed to combat antimicrobial resistance. A multidimensional chemical library screening strategy was used to identify compounds in the National Cancer Institute (NCI) diversity set V library ...
Shivani Gargvanshi, Gioia Heravi, Navid J. Ayon, William G. Gutheil   +3 more
doaj   +1 more source

Microsomes, Microsomal Phospholipids, and Fatty Acid Synthesis [PDF]

Journal of Biological Chemistry, 1969
Abstract The effect of microsomes on fatty acid synthesis by the soluble fraction of rat liver cells has been studied. It was shown that the microsomes contain a heat-labile inhibitory factor, presumably ATPase, and a heat-stable stimulatory factor.
Daniel W. Foster, William P. McWhorter
openaire   +2 more sources

The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidation

Czech Journal of Food Sciences, 2010
Isoflavone daidzein brings potential health benefits. Its antioxidant properties are considered to be responsible in part for its protective effects.
Heya Wang, Masibo Wanyonyi Martin, Shian Yin   +2 more
doaj   +1 more source

Phenylpropanoid-enriched broccoli seedling extract can reduce inflammatory markers and pain behavior

Journal of Translational Medicine, 2023
Background Pain is a worldwide problem requiring an effective, affordable, non-addictive therapy. Using the edible plant broccoli, a growth protocol was developed to induce a concentrated combinatorial of potential anti-inflammatories in seedlings ...
Aleksandra A. Gurgul, Yahya Najjar, Ana Chee, Howard An, Chun-Tao Che, Thomas J. Park, Katherine M. Warpeha   +6 more
doaj   +1 more source

Biotransformation of Liquiritigenin into Characteristic Metabolites by the Gut Microbiota

Molecules, 2022
The bioavailability of flavonoids is generally low after oral administration. The metabolic transformation of flavonoids by the gut microbiota may be one of the main reasons for this, although these metabolites have potential pharmacological activities ...
Adili Keranmu, Li-Bin Pan, Jie Fu, Pei Han, Hang Yu, Zheng-Wei Zhang, Hui Xu, Xin-Yu Yang, Jia-Chun Hu, Hao-Jian Zhang, Meng-Meng Bu, Jian-Dong Jiang, Nian-Zeng Xing, Yan Wang   +13 more
doaj   +1 more source