Results 131 to 140 of about 50,037 (190)
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Experientia, 1978
Studies which indicate the fusion of rat liver microsomal vesicles show that the rate of fusion of microsomal vesicles, as revealed by electron microscopic examinations, is dependent on the fusion temperature and the amount of detergent present in the microsomal suspension.
H. U. Schulze, Liliane Pop
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Studies which indicate the fusion of rat liver microsomal vesicles show that the rate of fusion of microsomal vesicles, as revealed by electron microscopic examinations, is dependent on the fusion temperature and the amount of detergent present in the microsomal suspension.
H. U. Schulze, Liliane Pop
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Effect of thiourea on microsomal oxidation alcohols and associated microsomal functions [PDF]
Biochemistry, 1979 Thiourea and diethylthiourea, two compounds which react with hydroxyl radicals, inhibited NADPH-dependent microsomal oxidation of ethanol and 1-butanol. Inhibition by both compounds was more effective in the presence of the catalase inhibitor, azide.
Elisa Dicker +3 more
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Biomedical chromotography, 2014
The metabolism by human liver microsomes of several new illicit drugs, that is, N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3- carboxamide (ADB-FUBINACA), N-(1-amino-3-methyl-1-oxobutan-2-yl)-1- (4-fluorobenzyl)-1H-indazole-3 ...
Takahiro Takayama +7 more
semanticscholar +1 more source
The metabolism by human liver microsomes of several new illicit drugs, that is, N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3- carboxamide (ADB-FUBINACA), N-(1-amino-3-methyl-1-oxobutan-2-yl)-1- (4-fluorobenzyl)-1H-indazole-3 ...
Takahiro Takayama +7 more
semanticscholar +1 more source
Microsomal metabolism of picene
Chemico-Biological Interactions, 1988Picene, a polycyclic aromatic hydrocarbon (PAH) of environmental relevance has recently been predicted to be carcinogenic, based on quantum mechanical calculation, although in several animal studies no carcinogenicity could be detected. In order to find out if the metabolism of this PAH can provide an explanation for its lack of carcinogenicity, picene
P. Petrovic +4 more
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Microsome-associated lumenal lipid droplets in the regulation of lipoprotein secretion
Current Opinion in Lipidology, 2013Purpose of review Liver is the major organ in mammals that possesses the capacity to release triglyceride within VLDL. VLDL assembly requires apolipoprotein (apo) B-100 with the assistance of microsomal triglyceride transfer protein (MTP), which ...
Z. Yao +4 more
semanticscholar +1 more source
2009
Proteomic profiling of subcellular compartments has many advantages over traditional proteomic approaches using whole cell lysates as it allows for detailed proteome analysis of a specific organelle and corresponding functional characteristics. The microsome is a critical, membranous compartment involved in the synthesis, sorting, and secretion of ...
Diana M, Wong, Khosrow, Adeli
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Proteomic profiling of subcellular compartments has many advantages over traditional proteomic approaches using whole cell lysates as it allows for detailed proteome analysis of a specific organelle and corresponding functional characteristics. The microsome is a critical, membranous compartment involved in the synthesis, sorting, and secretion of ...
Diana M, Wong, Khosrow, Adeli
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Journal of Pharmacy and Science, 2011
The purpose of this study was to investigate the ability of the microsome composition-based model to predict the unbound fraction determined in vitro in microsomal incubation system (fuinc ). Another objective was to make a comparative assessment between
P. Poulin, S. Haddad
semanticscholar +1 more source
The purpose of this study was to investigate the ability of the microsome composition-based model to predict the unbound fraction determined in vitro in microsomal incubation system (fuinc ). Another objective was to make a comparative assessment between
P. Poulin, S. Haddad
semanticscholar +1 more source
Microsomal hydroxylation of decane
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969Abstract 1. 1. Aliphatic hydrocarbons (hexane, octane and decane) were oxidized in the microsomes from the livers of mouse, rat, rabbit, beef, pigeon and chick embryo. 2. 2. The oxidation of decane by mouse liver microsomes required NADPH and O 2 .
Kusunose Masamichi +2 more
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Xenobiotica; the fate of foreign compounds in biological systems, 2010
We compare three different approaches to scale clearance (CL) from human hepatocyte and microsome CLint (intrinsic CL) for 52 drug compounds. By using the well-stirred model with protein binding included only 11% and 30% of the compounds were predicted ...
A. Sohlenius-Sternbeck +10 more
semanticscholar +1 more source
We compare three different approaches to scale clearance (CL) from human hepatocyte and microsome CLint (intrinsic CL) for 52 drug compounds. By using the well-stirred model with protein binding included only 11% and 30% of the compounds were predicted ...
A. Sohlenius-Sternbeck +10 more
semanticscholar +1 more source
Science, 1969
Deoxyribonucleic acid has been isolated from the microsomes of mouse liver homogenates under conditions designed to prevent or greatly reduce mitochondrial and nuclear contamination. The DNA rapidly incorporates tritiated thymidine, and this, together with its reannealing characteristics after thermal denaturation, shows that it is not mitochondrial or
Doris P. Courington +3 more
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Deoxyribonucleic acid has been isolated from the microsomes of mouse liver homogenates under conditions designed to prevent or greatly reduce mitochondrial and nuclear contamination. The DNA rapidly incorporates tritiated thymidine, and this, together with its reannealing characteristics after thermal denaturation, shows that it is not mitochondrial or
Doris P. Courington +3 more
openaire +3 more sources